DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15269 and Zscan10

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001028597.2	Gene:	Zscan10 / 332221	MGIID:	3040700	Length:	782	Species:	Mus musculus

Alignment Length:	588	Identity:	156/588 - (26%)
Similarity:	227/588 - (38%)	Gaps:	176/588 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SPARTSPTNGVQNLGAGAQLP--------PAQVTDFSISKILGKERKS-----AQDTSTNILDLS 62
            |..|..|.|   .||.|:::|        ..:||.:.:  ::|.|.::     |.:..|..:...
Mouse   250 SEKRAWPAN---PLGFGSRMPDNEELKVEEPKVTTWPV--VIGAESQTEKPEVAGEPLTQTVGQE 309

  Fly    63 KSSSNSIRSPQALGGLAIPSTPYASGAYSMLPPDLVAMANAT-----KFYAQFFPHLLPAYAAAA 122
            .||:       ..||     || |.|:      ::|.:..|:     :...||.          .
Mouse   310 TSST-------GWGG-----TP-ADGS------EVVKVRGASDAPEPQGEMQFI----------C 345

  Fly   123 AAAGLSTPPTSPYQTHQHQQHLPNQQ--------------------------------KRFFAPY 155
            ...|::.|..|..|.||.|.| ||.|                                :|..|.:
Mouse   346 TYCGVNFPEMSHLQAHQLQSH-PNLQPHPSSRSFRCLWCGKTFGRSSILKLHMRTHTDERPHACH 409

  Fly   156 VINGSVPPPPPLQQQQQPLIRTKSTACTRP--DCPECLDYYQRLQTGGYKQTAPLISPAASSVSS 218
            :.|...       :|...|.:...|..:.|  .|.||...:||                .||:
Mouse   410 LCNRRF-------RQSSHLTKHLLTHSSEPAFRCAECNQGFQR----------------RSSL-- 449

  Fly   219 STGSIRPVRDLIMSATGGAASTNISLTTVTNLSLNSVQATAVGMMPKMTGGLITTA--------- 274
                   ::.|:..|.|            .||:.|....|.|   |:|...|.:..
Mouse   450 -------MQHLLAHAQG------------KNLTPNPEGKTKV---PEMAAVLCSHCGQTFKRRSS 492

  Fly   275 ---------------VGSNSGAIGGIGGYNATSAEEISYKCRICEKVFGCSETLQAH-EKTHKSP 323
                           ...:.|::       ::|.|...|.|..|.|.|..||.|..| .:.|...
Mouse   493 LKRHLRNHAKDKDHLSSEDPGSL-------SSSQESNPYVCSDCGKAFRQSEQLMIHTRRVHTRE 550

  Fly   324 R-YECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPECGKTFNDKGYLSSHLKIHRNRKEYECPY 387
            | :.|..||:.|:|......|..:|.|.|..|  ||:|.|.|..:..|:.||..|.:.:.|.|..
Mouse   551 RPFSCQVCGRCFTQNSQLISHQQIHTGEKPHA--CPQCSKRFVRRAGLARHLLTHGSLRPYHCAQ 613

  Fly   388 CPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRS 452
            |.|||.|......|||.|||.||.:|||||:.|::...|.:|.|.|:||||:.|.:||..|.:.|
Mouse   614 CGKSFRQMRDLTRHVRCHTGEKPCRCNECGEGFTQNAHLARHQRIHTGEKPHACDICGHRFRNSS 678

  Fly   453 NMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCK-----PYVCPHPNCNQAFTQSSNM 512
            |:..|.|.|:|.:|:|||.|.::|.:..||:.||..|||.|     |..|  |.|.::|.:|.|:
Mouse   679 NLARHRRSHTGERPYSCPTCGRSFRRNAHLQRHLITHTGSKQEKEVPQEC--PECGKSFNRSCNL 741

  Fly   513 RTH 515
            ..|
Mouse   742 LRH 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	8/20 (40%)
		COG5048	<316..502	CDD:227381	78/192 (41%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		zf-C2H2	356..377	CDD:278523	8/20 (40%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	10/24 (42%)
		C2H2 Zn finger	385..405	CDD:275368	9/19 (47%)
		zf-H2C2_2	397..422	CDD:290200	14/24 (58%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..449	CDD:290200	11/22 (50%)
		zf-C2H2	439..461	CDD:278523	8/21 (38%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-C2H2	467..489	CDD:278523	9/21 (43%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	6/17 (35%)
Zscan10	NP_001028597.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		SCAN	39..123	CDD:153421
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..233
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..321		8/43 (19%)
		C2H2 Zn finger	345..372	CDD:275368	11/27 (41%)
		COG5048	366..767	CDD:227381	123/438 (28%)
		C2H2 Zn finger	380..400	CDD:275368	0/19 (0%)
		zf-H2C2_2	393..417	CDD:290200	3/30 (10%)
		C2H2 Zn finger	408..428	CDD:275368	3/26 (12%)
		C2H2 Zn finger	436..456	CDD:275368	8/44 (18%)
		C2H2 Zn finger	480..500	CDD:275368	0/19 (0%)
		zf-C2H2	480..500	CDD:278523	0/19 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..522		3/37 (8%)
		C2H2 Zn finger	526..547	CDD:275368	8/20 (40%)
		zf-C2H2	553..575	CDD:278523	6/21 (29%)
		C2H2 Zn finger	555..575	CDD:275368	6/19 (32%)
		zf-H2C2_2	568..592	CDD:290200	10/25 (40%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		SIR2	<592..>643	CDD:294129	22/50 (44%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		zf-H2C2_2	623..648	CDD:290200	14/24 (58%)
		C2H2 Zn finger	639..659	CDD:275368	9/19 (47%)
		zf-H2C2_2	651..676	CDD:290200	12/24 (50%)
		C2H2 Zn finger	667..687	CDD:275368	8/19 (42%)
		zf-H2C2_2	679..704	CDD:290200	11/24 (46%)
		C2H2 Zn finger	695..715	CDD:275368	8/19 (42%)
		C2H2 Zn finger	728..748	CDD:275368	7/19 (37%)
		zf-C2H2	754..776	CDD:278523
		C2H2 Zn finger	756..776	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000