DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG15269 and Plag1

DIOPT Version :9

Sequence 1:NP_609739.2 Gene:CG15269 / 34887 FlyBaseID:FBgn0028878 Length:587 Species:Drosophila melanogaster
Sequence 2:NP_001008317.1 Gene:Plag1 / 297804 RGDID:1305286 Length:499 Species:Rattus norvegicus


Alignment Length:300 Identity:80/300 - (26%)
Similarity:128/300 - (42%) Gaps:54/300 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   297 SYKCRICEKVFGCSETLQAHEKTHKSPR-YECA--DCGKGFSQLRNYKYHLSVHRGTKEFAAECP 358
            ::.|::|:|.|...|.|:.|..:|...| |:|.  ||.|.|......:.|::.|  :.|...:|.
  Rat    33 NFPCQLCDKAFNSVEKLKVHSFSHTGERPYKCTHQDCTKAFVSKYKLQRHMATH--SPEKTHKCN 95

  Fly   359 ECGKTFNDKGYLSSHLKIH-RNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPH-KCNECGKRFS 421
            .|.|.|:.|.:|.:||..| .|::.::|..|.||:|.::.|..|:.:|...... .|..|.:.|.
  Rat    96 YCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFKRHLALHAATSGDLTCKVCLQTFE 160

  Fly   422 RKMLLKQHMRTHSG-------EKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKK 479
            ...:|.:|:::|:|       ||.:||..|.:.|..|.::..|..:|:|.|.|.|..|.:.|.:|
  Rat   161 STGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFYTRKDVRRHMVVHTGRKDFLCQYCAQRFGRK 225

  Fly   480 HHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTHAKKCQYRPLDGLTVTSSALPVPGKQQTGP 544
            .||..|:.                    :|.|.  ...|.:..|:|.|...:..:.||.|.:..|
  Rat   226 DHLTRHMK--------------------KSHNQ--ELLKVKTEPVDFLDPFTCNMSVPIKDELLP 268

  Fly   545 PPTLAMAMAQTFQMPPPPGVLTPGSGPSQPPSQQTLLSNL 584
            ..:|                  |.|.....|...||..||
  Rat   269 VMSL------------------PSSELLSKPFTNTLQLNL 290

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15269NP_609739.2 C2H2 Zn finger 300..320 CDD:275368 7/19 (37%)
COG5048 <316..502 CDD:227381 56/197 (28%)
C2H2 Zn finger 327..347 CDD:275368 6/21 (29%)
zf-C2H2 356..377 CDD:278523 8/20 (40%)
C2H2 Zn finger 357..377 CDD:275368 8/19 (42%)
zf-H2C2_2 369..394 CDD:290200 9/25 (36%)
C2H2 Zn finger 385..405 CDD:275368 7/19 (37%)
zf-H2C2_2 397..422 CDD:290200 6/25 (24%)
C2H2 Zn finger 413..433 CDD:275368 5/19 (26%)
zf-H2C2_2 426..449 CDD:290200 9/29 (31%)
zf-C2H2 439..461 CDD:278523 6/21 (29%)
C2H2 Zn finger 441..461 CDD:275368 5/19 (26%)
zf-C2H2 467..489 CDD:278523 8/21 (38%)
C2H2 Zn finger 469..489 CDD:275368 7/19 (37%)
C2H2 Zn finger 497..515 CDD:275368 2/17 (12%)
Plag1NP_001008317.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33 79/299 (26%)
Interaction with KPNA2. /evidence=ECO:0000250 2..84 16/50 (32%)
Nuclear localization signal. /evidence=ECO:0000250 22..25
C2H2 Zn finger 36..56 CDD:275368 7/19 (37%)
Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250 41..242 62/224 (28%)
SFP1 <58..139 CDD:227516 26/82 (32%)
C2H2 Zn finger 64..86 CDD:275368 6/21 (29%)
zf-H2C2_2 79..103 CDD:404364 7/25 (28%)
C2H2 Zn finger 94..114 CDD:275368 8/19 (42%)
C2H2 Zn finger 123..143 CDD:275368 7/19 (37%)
C2H2 Zn finger 152..172 CDD:275368 5/19 (26%)
C2H2 Zn finger 187..207 CDD:275368 5/19 (26%)
C2H2 Zn finger 215..233 CDD:275368 7/17 (41%)
Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250 243..499 14/65 (22%)
Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250 243..383 14/65 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..400
Massively activates transcription. /evidence=ECO:0000250 384..499
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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