DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15269 and Zfp280b

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001099854.1	Gene:	Zfp280b / 294343	RGDID:	1565460	Length:	532	Species:	Rattus norvegicus

Alignment Length:	671	Identity:	139/671 - (20%)
Similarity:	209/671 - (31%)	Gaps:	253/671 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DLSPSPARTSPTN---------------GVQNLGAGAQLPPAQVTDFS---ISKILGK------- 46
            |..|.|....|..               ||:|:...|:|....||..|   .|.||.:
  Rat    13 DPEPQPRSQEPIQVLDEDDSEDAELIFVGVENVKEDAELIFVGVTSTSQPANSNILNRVTPGSRL 77

  Fly    47 ERK--SAQDTSTN----------------ILDLSKSSSNSIRSPQALGGLAIPSTPYASGAYSML 93
            :||  ..::|:|.                :|.:|.:.|.|..||..:..|:  .:.|.|.: .::
  Rat    78 KRKHDRLRETTTQRLQPSPPAAPTSEAAIVLPVSPAESRSTDSPIIIEPLS--ESDYKSNS-QVV 139

  Fly    94 PPD-------LVAMANATKFYAQFFPHLLPAYAAAAAAAGLSTPPTSPYQTHQHQQHLPNQQKRF 151
            |..       |..::::....|:          ||.:..||:   .|.|.:..|....|.:.:|.
  Rat   140 PSSSSKCCSPLATLSSSESGPAR----------AACSGGGLN---ESLYVSKCHFSINPQRPERS 191

  Fly   152 F-APYVINGSVPPPPPLQ----QQQQPLIRTKSTACTRPDCPECLDYYQRLQTGGYKQTAPLISP 211
            . ....::.::||..|..    ||:.|.:          :.|:.|:.:    ..|    |||
  Rat   192 IEIVEELSSALPPSGPFHTSNAQQRTPSL----------EAPKSLNLF----VNG----APL--- 235

  Fly   212 AASSVSSSTGSIRPVRDLIMSATGGAASTNISLTTVTNLSLNSVQATAVGMMPKMTGGLITTAVG 276
                   |...:.|.:|      .|:..|:.|       ||.|.:.    ..|| .|.|......
  Rat   236 -------SGDPVHPRQD------SGSVDTDFS-------SLASPET----FDPK-KGSLTLLLSD 275

  Fly   277 SNSGAIGGIGGYNATSAEEISYKCRICEKVFGCSETLQAHEKTHKSPRYECADCGKGFSQLR--- 338
            ...|...|.|                           :..:|||.:  ::|..|.|....::
  Rat   276 FYYGQYKGEG---------------------------KPEQKTHTT--FKCPSCSKALKNVKFMN 311

  Fly   339 NYKYHLSVHRGTKEFAAE----CPECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFN 399
            :.|:||.:.|...:.|.|    |..|.:.|.....|..|:.
  Rat   312 HTKHHLELERQGSDEAWESHTTCLRCHRLFASPFQLECHID------------------------ 352

  Fly   400 MHVRIHTGVKP-HKCNECGKRFSRKMLLKQHMRTH--SGEKPYQCSVC---GKSFAD-RSNMTLH 457
               |:||...| ..|..|...|..:.:|.:||:.:  .||.||.|.||   ...||| .::.|
  Rat   353 ---RVHTAPDPCVVCKICELSFETEQVLLEHMKDNHKPGEMPYVCQVCKYRSSVFADVETHFT-- 412

  Fly   458 HRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPH------------PNCNQAFTQSS 510
             :.|...|...||.|.|.|            .|| .||:| |            ..|...|....
  Rat   413 -KCHVNTKNLLCPFCLKIF------------RTG-MPYMC-HCRGHWERNGHQCSKCRLQFLTFK 462

  Fly   511 NMRTHAKKCQY-----RPLDGLTVTSSALPVPGKQQTGPPPTLAMAMAQTFQMPPPP-------- 562
            ....|..:|..     :.|:||                ||.|..:     .|:...|
  Rat   463 EKMEHKTQCHQMFRKPKQLEGL----------------PPETKVV-----IQVSVKPVEAESVEV 506

  Fly   563 ---GVLTPGSGPSQPPSQQTL 580
               .|.|....||.|.||..|
  Rat   507 ASITVSTTDWEPSCPRSQGRL 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	1/19 (5%)
		COG5048	<316..502	CDD:227381	51/211 (24%)
		C2H2 Zn finger	327..347	CDD:275368	6/22 (27%)
		zf-C2H2	356..377	CDD:278523	6/24 (25%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
		zf-H2C2_2	369..394	CDD:290200	2/24 (8%)
		C2H2 Zn finger	385..405	CDD:275368	1/19 (5%)
		zf-H2C2_2	397..422	CDD:290200	7/25 (28%)
		C2H2 Zn finger	413..433	CDD:275368	6/19 (32%)
		zf-H2C2_2	426..449	CDD:290200	10/27 (37%)
		zf-C2H2	439..461	CDD:278523	8/25 (32%)
		C2H2 Zn finger	441..461	CDD:275368	7/23 (30%)
		zf-C2H2	467..489	CDD:278523	5/21 (24%)
		C2H2 Zn finger	469..489	CDD:275368	5/19 (26%)
		C2H2 Zn finger	497..515	CDD:275368	4/29 (14%)
Zfp280b	NP_001099854.1	DUF4195	52..219	CDD:404681	36/182 (20%)
		C2H2 Zn finger	334..355	CDD:275368	6/47 (13%)
		C2H2 Zn finger	364..385	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910