DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and Zfp418

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_006228239.1	Gene:	Zfp418 / 292548	RGDID:	1311663	Length:	670	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	132/463 - (28%)
Similarity:	179/463 - (38%)	Gaps:	122/463 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 HLLPAYAAAAAAAGLSTPPTSPYQTHQHQQHLPNQQKRFFAPYVINGSVPPPPPLQQQQQPLIRT 177
            |.|..|....:|.|       .::::..:|.|             |...|.|..:.|.:
  Rat   232 HRLHEYPGVCSAKG-------GFESNSCEQDL-------------NKYSPAPFRMDQTE------ 270

  Fly   178 KSTACTRP-DCPEC---------LDYYQRLQTG--GYKQTAPLISPAASSVSSST---------G 221
                 .|| :|..|         |..:||..||  .||     ......|...|:         .
  Rat   271 -----NRPYECHVCGKWFGQKATLRIHQRRHTGEKPYK-----CGECGKSFCQSSNLSEHCRVHS 325

  Fly   222 SIRPVRDLIMSATGGAASTNISLTTVTNLSLNSVQATAVGMMP----------KMTGGLITTAVG 276
            ..||...|......|..|           ||...|.|..|..|          :....|||
  Rat   326 GERPFECLECGKAFGCHS-----------SLLRHQRTHTGEWPYECSDCGRLFRQIVSLIT---- 375

  Fly   277 SNSGAIGGIGGYNATSAEEISYKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNY 340
                       :..|...|..|:|..|||.|....||..|::.|...: |.|..|||.|||..|.
  Rat   376 -----------HQRTHTTEKPYECGQCEKSFSHKATLTVHQRVHTGEKPYHCEACGKSFSQSANL 429

  Fly   341 KYHLSVHRGTKEFAA--------------------------ECPECGKTFNDKGYLSSHLKIHRN 379
            ..|..:|.|.|.:..                          ||.||||.|....||..|.:||..
  Rat   430 IKHSKIHTGEKPYECGECGLCFRQRATLMKHQRTHTSERPYECRECGKFFKQYFYLIEHRRIHTT 494

  Fly   380 RKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSVC 444
            .:.|||..|.||:.|:.....|.|:|||..|:||.||||.|..|..||:|.|||:||:||:|:.|
  Rat   495 TEFYECEQCGKSYTQKATLIRHQRVHTGESPYKCEECGKAFEYKSRLKRHQRTHTGERPYECAKC 559

  Fly   445 GKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQS 509
            ||.|.:..|:..|.::|:..||:.|..|.|.|:::..|..|...|||.:||.|  ..|.:.|:::
  Rat   560 GKFFRESYNLAEHQKIHTKAKPYHCDQCGKCFSRRADLVKHQRVHTGERPYTC--GECGKTFSRT 622

  Fly   510 SNMRTHAK 517
            :|:..|.:
  Rat   623 TNLVQHRR 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		COG5048	<316..502	CDD:227381	80/212 (38%)
		C2H2 Zn finger	327..347	CDD:275368	9/19 (47%)
		zf-C2H2	356..377	CDD:278523	10/20 (50%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	11/24 (46%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	13/24 (54%)
		C2H2 Zn finger	413..433	CDD:275368	11/19 (58%)
		zf-H2C2_2	426..449	CDD:290200	14/22 (64%)
		zf-C2H2	439..461	CDD:278523	8/21 (38%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-C2H2	467..489	CDD:278523	6/21 (29%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..515	CDD:275368	4/17 (24%)
Zfp418	XP_006228239.1	KRAB	35..>76	CDD:214630
		KRAB	35..74	CDD:279668
		COG5048	<190..396	CDD:227381	45/225 (20%)
		C2H2 Zn finger	276..296	CDD:275368	5/19 (26%)
		zf-H2C2_2	289..311	CDD:290200	7/26 (27%)
		COG5048	300..657	CDD:227381	112/364 (31%)
		C2H2 Zn finger	304..324	CDD:275368	2/19 (11%)
		zf-H2C2_2	316..339	CDD:290200	3/22 (14%)
		C2H2 Zn finger	332..352	CDD:275368	6/30 (20%)
		zf-H2C2_2	344..369	CDD:290200	6/24 (25%)
		C2H2 Zn finger	360..380	CDD:275368	3/34 (9%)
		zf-H2C2_2	372..397	CDD:290200	11/39 (28%)
		C2H2 Zn finger	388..408	CDD:275368	8/19 (42%)
		zf-H2C2_2	401..425	CDD:290200	9/23 (39%)
		C2H2 Zn finger	416..436	CDD:275368	9/19 (47%)
		C2H2 Zn finger	444..464	CDD:275368	0/19 (0%)
		zf-H2C2_2	457..481	CDD:290200	7/23 (30%)
		C2H2 Zn finger	472..492	CDD:275368	9/19 (47%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		zf-H2C2_2	513..537	CDD:290200	13/23 (57%)
		C2H2 Zn finger	528..548	CDD:275368	11/19 (58%)
		zf-H2C2_2	541..563	CDD:290200	14/21 (67%)
		C2H2 Zn finger	556..576	CDD:275368	7/19 (37%)
		zf-H2C2_2	568..593	CDD:290200	9/24 (38%)
		C2H2 Zn finger	584..604	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..621	CDD:290200	10/26 (38%)
		C2H2 Zn finger	612..632	CDD:275368	5/21 (24%)
		zf-H2C2_2	624..649	CDD:290200	2/7 (29%)
		C2H2 Zn finger	640..660	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100