DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZNF521

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_056276.1	Gene:	ZNF521 / 25925	HGNCID:	24605	Length:	1311	Species:	Homo sapiens

Alignment Length:	326	Identity:	82/326 - (25%)
Similarity:	137/326 - (42%)	Gaps:	62/326 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 GGIGGYNATSAEEISYKCRICEKVFGCSETLQAHEKTH--KSPRYECADCGKGFSQLRNYKYHLS 345
            ||.|         :.|.|:.|:|.|.....|:.||::|  |.| ::|..|.:.|...|:...|:.
Human   112 GGPG---------LPYPCQFCDKSFSRLSYLKHHEQSHSDKLP-FKCTYCSRLFKHKRSRDRHIK 166

  Fly   346 VHRGTKEFAAECPECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVK- 409
            :|.|.|::  .|.||...|:...:|..|||.|.:.|.|:|..|.:.|....:.:.|:::|...|
Human   167 LHTGDKKY--HCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKD 229

  Fly   410 ---------------PHKCNECGKRFSRKMLLKQHM-RTHSGEKP------YQCSVCGKSFADRS 452
                           ..||::|.:.|.....|::|: ..|....|      .||..|.:.|.:.:
Human   230 GSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEET 294

  Fly   453 NMTLH-HRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTHA 516
            ::..| .::|||.|..||.:|.::|.....|.:|::.|.  :|..|.|.|.....|......:..
Human   295 SLMNHMEQVHSGEKKNSCSICSESFHTVEELYSHMDSHQ--QPESCNHSNSPSLVTVGYTSVSST 357

  Fly   517 KKCQYRPLDGLTVTSSALPVP---GKQQTGPPPTLAMAMAQTFQMPPPPGVLTPGSGPSQPPSQQ 578
            .......:|..|:..:|.|:|   |:::         |..||..|          :|||...::.
Human   358 TPDSNLSVDSSTMVEAAPPIPKSRGRKR---------AAQQTPDM----------TGPSSKQAKV 403

  Fly   579 T 579
            |
Human   404 T 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	57/211 (27%)
		C2H2 Zn finger	327..347	CDD:275368	5/19 (26%)
		zf-C2H2	356..377	CDD:278523	8/20 (40%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	10/24 (42%)
		C2H2 Zn finger	385..405	CDD:275368	4/19 (21%)
		zf-H2C2_2	397..422	CDD:290200	7/40 (18%)
		C2H2 Zn finger	413..433	CDD:275368	5/20 (25%)
		zf-H2C2_2	426..449	CDD:290200	7/29 (24%)
		zf-C2H2	439..461	CDD:278523	5/22 (23%)
		C2H2 Zn finger	441..461	CDD:275368	4/20 (20%)
		zf-C2H2	467..489	CDD:278523	6/21 (29%)
		C2H2 Zn finger	469..489	CDD:275368	5/19 (26%)
		C2H2 Zn finger	497..515	CDD:275368	4/17 (24%)
ZNF521	NP_056276.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..108
		C2H2 Zn finger	120..140	CDD:275368	7/19 (37%)
		COG5048	128..>216	CDD:227381	28/90 (31%)
		C2H2 Zn finger	148..168	CDD:275368	5/19 (26%)
		C2H2 Zn finger	176..196	CDD:275368	8/19 (42%)
		C2H2 Zn finger	204..224	CDD:275368	4/19 (21%)
		C2H2 Zn finger	248..265	CDD:275368	4/16 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..397		11/66 (17%)
		C2H2 Zn finger	407..428	CDD:275368
		C2H2 Zn finger	439..460	CDD:275368
		C2H2 Zn finger	479..498	CDD:275368
		C2H2 Zn finger	636..656	CDD:275368
		C2H2 Zn finger	666..686	CDD:275368
		C2H2 Zn finger	696..713	CDD:275368
		C2H2 Zn finger	724..745	CDD:275368
		C2H2 Zn finger	754..774	CDD:275368
		C2H2 Zn finger	785..805	CDD:275368
		C2H2 Zn finger	811..829	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..882
		C2H2 Zn finger	888..909	CDD:275368
		C2H2 Zn finger	932..952	CDD:275368
		C2H2 Zn finger	961..981	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1168..1188
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1258..1279	CDD:275368
		C2H2 Zn finger	1288..1307	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910