DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZNF473

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001006657.1	Gene:	ZNF473 / 25888	HGNCID:	23239	Length:	871	Species:	Homo sapiens

Alignment Length:	315	Identity:	108/315 - (34%)
Similarity:	136/315 - (43%)	Gaps:	90/315 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 EEISYKCRICEKVFGCSETLQAHEKTHK---SPRYECADCGKGF-------------SQLRNYKY 342
            :|..:||..|||.|.||:.|..||:.|.   .| :||..|||.|             |::|.||:
Human   558 KEKCFKCNKCEKTFSCSKYLTQHERIHTRGVKP-FECDQCGKAFGQSTRLIHHQRIHSRVRLYKW 621

  Fly   343 --------------------------------------HLS----VHRGTKEFAAE--------- 356
                                                  |||    :|.|...|...
Human   622 GEQGKAISSASLIKLQSFHTKEHPFKCNECGKTFSHSAHLSKHQLIHAGENPFKCSKCDRVFTQR 686

  Fly   357 -----------------CPECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRI 404
                             |.||||||.....||.|.:||...|.|.|.||.|:|........|.||
Human   687 NYLVQHERTHARKKPLVCNECGKTFRQSSCLSKHQRIHSGEKPYVCDYCGKAFGLSAELVRHQRI 751

  Fly   405 HTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSC 469
            |||.||:.|.||||.|::...|..|.|.|:|||||:|..|||:||.::|:|.|.|:|:|.||:||
Human   752 HTGEKPYVCQECGKAFTQSSCLSIHRRVHTGEKPYRCGECGKAFAQKANLTQHQRIHTGEKPYSC 816

  Fly   470 PLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTHAK---KCQY 521
            .:|.|||....||..||..||....|.|  ..|.:||...|::..|.:   |.||
Human   817 NVCGKAFVLSAHLNQHLRVHTQETLYQC--QRCQKAFRCHSSLSRHQRVHNKQQY 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	10/19 (53%)
		COG5048	<316..502	CDD:227381	90/269 (33%)
		C2H2 Zn finger	327..347	CDD:275368	12/74 (16%)
		zf-C2H2	356..377	CDD:278523	10/46 (22%)
		C2H2 Zn finger	357..377	CDD:275368	10/19 (53%)
		zf-H2C2_2	369..394	CDD:290200	12/24 (50%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	14/24 (58%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..449	CDD:290200	13/22 (59%)
		zf-C2H2	439..461	CDD:278523	11/21 (52%)
		C2H2 Zn finger	441..461	CDD:275368	10/19 (53%)
		zf-C2H2	467..489	CDD:278523	10/21 (48%)
		C2H2 Zn finger	469..489	CDD:275368	9/19 (47%)
		C2H2 Zn finger	497..515	CDD:275368	5/17 (29%)
ZNF473	NP_001006657.1	KRAB_A-box	6..45	CDD:143639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..81
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..164
		COG5048	207..614	CDD:227381	20/56 (36%)
		C2H2 Zn finger	211..231	CDD:275368
		C2H2 Zn finger	239..259	CDD:275368
		C2H2 Zn finger	267..286	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..318
		Interaction with SLBP/pre-mRNA complex	312..552
		C2H2 Zn finger	322..342	CDD:275368
		C2H2 Zn finger	349..369	CDD:275368
		C2H2 Zn finger	377..397	CDD:275368
		C2H2 Zn finger	405..425	CDD:275368
		C2H2 Zn finger	433..453	CDD:275368
		COG5048	457..860	CDD:227381	104/304 (34%)
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	489..509	CDD:275368
		C2H2 Zn finger	517..537	CDD:275368
		C2H2 Zn finger	564..584	CDD:275368	10/19 (53%)
		C2H2 Zn finger	593..613	CDD:275368	5/19 (26%)
		C2H2 Zn finger	648..668	CDD:275368	3/19 (16%)
		C2H2 Zn finger	676..696	CDD:275368	0/19 (0%)
		C2H2 Zn finger	704..724	CDD:275368	10/19 (53%)
		C2H2 Zn finger	732..752	CDD:275368	7/19 (37%)
		C2H2 Zn finger	760..780	CDD:275368	9/19 (47%)
		C2H2 Zn finger	788..808	CDD:275368	10/19 (53%)
		C2H2 Zn finger	816..836	CDD:275368	9/19 (47%)
		C2H2 Zn finger	844..864	CDD:275368	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910