DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15269 and ZNF324

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_005258770.1	Gene:	ZNF324 / 25799	HGNCID:	14096	Length:	558	Species:	Homo sapiens

Alignment Length:	555	Identity:	149/555 - (26%)
Similarity:	229/555 - (41%)	Gaps:	139/555 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 AAAAAAGLSTPPTSPYQTHQHQQHLPNQQKRFFAPYVINGSVPPPPPLQQQQQPLIRTKSTACTR 184
            |..|:.||||          .:..:..|.:|...|:|.:|:          ...|.||.
Human    40 ALVASLGLST----------SRPRVVIQLERGEEPWVPSGT----------DTTLSRTT------ 78

  Fly   185 PDCPECLDYYQRLQTG----------------GYKQTAPLISPAASSVSSSTGSIR--------- 224
                     |:|...|                .:..|.|.::.:...|:.:..|::
Human    79 ---------YRRRNPGSWSLTEDRDVSGEWPRAFPDTPPGMTTSVFPVAGACHSVKSLQRQRGAS 134

  Fly   225 PVRD-------------LIMSATGGAASTNISLT--------------TVTNLSL-------NSV 255
            |.|:             |::.:..|.||.::.||              |:|..:|       ...
Human   135 PSRERKPTGVSVIYWERLLLGSGSGQASVSLRLTSPLRPPEGVRLREKTLTEHALLGRQPRTPER 199

  Fly   256 QATAVGMMPKMTGGL---ITTAVGSNSGAIGGI--------GGYNATSAEEI---------SYKC 300
            |......:|..|.|.   :..|.|.....:|.:        ||...::.:|:         |::|
Human   200 QKPCAQEVPGRTFGSAQDLEAAGGRGHHRMGAVWQEPHRLLGGQEPSTWDELGEALHAGEKSFEC 264

  Fly   301 RICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPECGKTF 364
            |.|.|||..|..|..|.:||...| ||||.|||.|||..:...|..:|.|...:|  ||.|||.|
Human   265 RACSKVFVKSSDLLKHLRTHTGERPYECAQCGKAFSQTSHLTQHQRIHSGETPYA--CPVCGKAF 327

  Fly   365 NDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQH 429
            .....|..|.:||...|.:.|..|.|:|:.....:.|.:||.|.:|:.|.:||:||.|...|.||
Human   328 RHSSSLVRHQRIHTAEKSFRCSECGKAFSHGSNLSQHRKIHAGGRPYACAQCGRRFCRNSHLIQH 392

  Fly   430 MRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKP 494
            .|||:||||:.|::||.:|:..|::..|.|:|:|.|||:||.|.:||:...:|..|...|||.:|
Human   393 ERTHTGEKPFVCALCGAAFSQGSSLFKHQRVHTGEKPFACPQCGRAFSHSSNLTQHQLLHTGERP 457

  Fly   495 YVCPHPNCNQAFTQSSNMRTHAK-----------KC--QYRPLDGL----TVTSSALPVPGKQQT 542
            :.|  .:|.:||.:.:.:.:|.:           :|  .:|....|    .:.:....|...:.:
Human   458 FRC--VDCGKAFAKGAVLLSHRRIHTGEKPFVCTQCGRAFRERPALFHHQRIHTGEKTVRRSRAS 520

  Fly   543 GPPPTLAMAMAQTFQMPPPPGVLTPGSGP---SQP 574
            ..|...::|.|.:...|......||.|||   |||
Human   521 LHPQARSVAGASSEGAPAKETEPTPASGPAAVSQP 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	9/19 (47%)
		COG5048	<316..502	CDD:227381	78/186 (42%)
		C2H2 Zn finger	327..347	CDD:275368	9/19 (47%)
		zf-C2H2	356..377	CDD:278523	8/20 (40%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	9/24 (38%)
		C2H2 Zn finger	385..405	CDD:275368	5/19 (26%)
		zf-H2C2_2	397..422	CDD:290200	10/24 (42%)
		C2H2 Zn finger	413..433	CDD:275368	10/19 (53%)
		zf-H2C2_2	426..449	CDD:290200	13/22 (59%)
		zf-C2H2	439..461	CDD:278523	7/21 (33%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-C2H2	467..489	CDD:278523	8/21 (38%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..515	CDD:275368	4/17 (24%)
ZNF324	XP_005258770.1	KRAB	6..66	CDD:214630	9/35 (26%)
		KRAB	6..45	CDD:279668	2/4 (50%)
		C2H2 Zn finger	264..284	CDD:275368	9/19 (47%)
		COG5048	<268..468	CDD:227381	85/203 (42%)
		zf-H2C2_2	276..301	CDD:290200	13/24 (54%)
		C2H2 Zn finger	292..312	CDD:275368	9/19 (47%)
		zf-H2C2_2	304..329	CDD:290200	10/26 (38%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		zf-H2C2_2	332..357	CDD:290200	9/24 (38%)
		C2H2 Zn finger	348..368	CDD:275368	5/19 (26%)
		zf-C2H2	374..396	CDD:278523	10/21 (48%)
		C2H2 Zn finger	376..396	CDD:275368	10/19 (53%)
		zf-H2C2_2	388..413	CDD:290200	14/24 (58%)
		C2H2 Zn finger	404..424	CDD:275368	7/19 (37%)
		zf-H2C2_2	416..441	CDD:290200	12/24 (50%)
		C2H2 Zn finger	432..452	CDD:275368	7/19 (37%)
		COG5048	437..>524	CDD:227381	17/88 (19%)
		zf-H2C2_2	444..468	CDD:290200	9/25 (36%)
		C2H2 Zn finger	460..480	CDD:275368	5/21 (24%)
		zf-H2C2_2	473..495	CDD:290200	2/21 (10%)
		C2H2 Zn finger	488..508	CDD:275368	3/19 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910