DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and Zfp454

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001369380.1	Gene:	Zfp454 / 237758	MGIID:	2679253	Length:	536	Species:	Mus musculus

Alignment Length:	529	Identity:	146/529 - (27%)
Similarity:	214/529 - (40%)	Gaps:	129/529 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PTNGVQNLGAGAQLPPAQVTDFSISKILGKERKSAQDTSTNILDLSKSSSNSIRSPQALGGLAIP 81
            |..|...:....:...|.:.:....:.:.|||..|     |:.:........::..|.:  |...
Mouse   103 PVTGEITVAMSKKFLKADIPEKESDQWIAKERACA-----NLFNWQCQEGQEVKLQQVV--LTQQ 160

  Fly    82 STPYASGAYSMLPPDLVAMANATKFYAQFFPHLLPAYAAAAAAAGLSTPPTSPYQTHQ--HQQHL 144
            :||      |.|....|...:::...:|.......|:..:......|  .:|..:.||  |.:.|
Mouse   161 NTP------SKLSEQRVRAESSSPIQSQRSQASKTAFECSECGKAFS--KSSTLKKHQKLHTEKL 217

  Fly   145 PNQQKRFFAPYVINGSVPPPPPLQQQQQPLIRTKSTACTRPDCPEC---------LDYYQRLQTG 200
            ...||               .|::::             |..|.||         |.::||:.||
Mouse   218 NPSQK---------------SPMKEK-------------RYKCRECGKAFHQSTHLIHHQRVHTG 254

  Fly   201 GYKQTAPLISP-------AASSVSSS--------TGSIRPVRDLIMSATGGAASTNISLTTVTNL 250
            .        .|       .|.|||||        ||. :|..   .:..|.|...||.|:
Mouse   255 E--------KPYQCKDCGKAFSVSSSLSYHQKIHTGE-KPFE---CNVCGKAFIRNIHLS----- 302

  Fly   251 SLNSVQATAVGMMPKMTGGLITTAVGSNSGAIGGIGGYNATSAEEISYKCRICEKVFGCSETLQA 315
                                                .::.....|..::|.:|:|.|.|...|..
Mouse   303 ------------------------------------HHHRMHTGEKPFQCNLCDKAFVCRAHLTK 331

  Fly   316 HEKTH--KSPRYECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPECGKTFNDKGYLSSHLKIHR 378
            |:..|  |.| |:|.:|||.|:|..::..|..:|.|.|.|  ||.||||.|.....|:.|.:||.
Mouse   332 HQHIHSGKKP-YKCNECGKAFNQSTSFLQHQRIHTGEKPF--ECNECGKAFRVNSSLTEHQRIHT 393

  Fly   379 NRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSV 443
            ..|.|:|..|.|:|....:|..|.:||||.||::|..|.|.|..:..|.||.|||:|||||.|::
Mouse   394 GEKPYQCIECGKAFRDNSSFARHRKIHTGEKPYRCGLCEKAFRDQSALAQHQRTHTGEKPYTCNI 458

  Fly   444 CGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQ 508
            |.|:|:|.|.:|.|.|:|:..||:.|..|.|||.:..||..|...|||.|||.|  ..|.:||.|
Mouse   459 CEKAFSDHSALTQHKRIHTREKPYKCKTCGKAFIRSTHLIQHQRIHTGEKPYKC--NTCGKAFNQ 521

  Fly   509 SSNMRTHAK 517
            ::|:..|.:
Mouse   522 TANLAQHQR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	83/187 (44%)
		C2H2 Zn finger	327..347	CDD:275368	7/19 (37%)
		zf-C2H2	356..377	CDD:278523	9/20 (45%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	10/24 (42%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	12/24 (50%)
		C2H2 Zn finger	413..433	CDD:275368	8/19 (42%)
		zf-H2C2_2	426..449	CDD:290200	14/22 (64%)
		zf-C2H2	439..461	CDD:278523	10/21 (48%)
		C2H2 Zn finger	441..461	CDD:275368	9/19 (47%)
		zf-C2H2	467..489	CDD:278523	8/21 (38%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	6/17 (35%)
Zfp454	NP_001369380.1	KRAB	14..67	CDD:214630
		C2H2 Zn finger	193..213	CDD:275368	4/21 (19%)
		COG5048	197..532	CDD:227381	129/422 (31%)
		C2H2 Zn finger	232..252	CDD:275368	6/19 (32%)
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		C2H2 Zn finger	288..308	CDD:275368	5/60 (8%)
		C2H2 Zn finger	316..336	CDD:275368	7/19 (37%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		C2H2 Zn finger	372..392	CDD:275368	8/19 (42%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	428..448	CDD:275368	8/19 (42%)
		C2H2 Zn finger	456..476	CDD:275368	9/19 (47%)
		C2H2 Zn finger	484..504	CDD:275368	8/19 (42%)
		C2H2 Zn finger	512..532	CDD:275368	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910