DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZNF485

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001305069.1	Gene:	ZNF485 / 220992	HGNCID:	23440	Length:	441	Species:	Homo sapiens

Alignment Length:	414	Identity:	125/414 - (30%)
Similarity:	185/414 - (44%)	Gaps:	71/414 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 PLQQQQQPL-IRTKSTACTRPDCPECLDYYQR-------LQTGGYKQTAPLISPAASSVSSSTGS 222
            |..|.|.|| ....:.|.||.:... ||..||       |:..|...:..|:|.....::.....
Human     3 PRAQIQGPLTFGDVAVAFTRIEWRH-LDAAQRALYRDVMLENYGNLVSVGLLSSKPKLITQLEQG 66

  Fly   223 IRPVRDLIMSATGGAASTNISL-TTVTNLSLNSVQATAVGMMPK---MTGGLITTAVGSNSGAIG 283
            ..|..::..:.:|..|..:... |.::.|..::.:|:.:|...|   |..||
Human    67 AEPWTEVREAPSGTHAVEDYWFETKMSALKQSTSEASVLGERTKSVMMEKGL------------- 118

  Fly   284 GIGGYNATSAEEISYKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVH 347
               .:...|:.|.:|||:.|.|||..:.:..:|::.|.|.: ::|.:||..|....:...|..||
Human   119 ---DWEGRSSTEKNYKCKECGKVFKYNSSFISHQRNHTSEKPHKCKECGIAFMNSSSLLNHHKVH 180

  Fly   348 RG--------------------------TKEFAAECPECGKTFNDKGYLSSHLKIHRNRKEYECP 386
            .|                          ::|...:|.||||||.....|.||.:||..:|.|:|.
Human   181 AGKQPYRCIECGKFLKKHSTFINHQRIHSREKPHKCIECGKTFRKNSILLSHQRIHTGQKPYKCN 245

  Fly   387 YCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADR 451
            .|.|:|.|..|...|.|||:|.||.|||:||:.|.....:.:|.:.|:|||||||:.|||:|...
Human   246 DCGKAFAQNAALTRHERIHSGEKPFKCNKCGRAFRDNSTVLEHQKIHTGEKPYQCNECGKAFRKS 310

  Fly   452 SNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMR--- 513
            |.:..|.|:|:|.||:.|..|.|:|........|...|:|.|||.|  .:|.:|||:||.:.
Human   311 STLISHQRMHTGEKPYHCSKCGKSFRYSSSFAGHQKTHSGNKPYQC--RDCGKAFTKSSTLTGHQ 373

  Fly   514 --------THAKKC--QYRPLDGL 527
                    .|.|||  .:|...||
Human   374 RIHTGEKPYHCKKCGKAFRHSSGL 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		COG5048	<316..502	CDD:227381	76/212 (36%)
		C2H2 Zn finger	327..347	CDD:275368	5/19 (26%)
		zf-C2H2	356..377	CDD:278523	10/20 (50%)
		C2H2 Zn finger	357..377	CDD:275368	10/19 (53%)
		zf-H2C2_2	369..394	CDD:290200	11/24 (46%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	397..422	CDD:290200	14/24 (58%)
		C2H2 Zn finger	413..433	CDD:275368	6/19 (32%)
		zf-H2C2_2	426..449	CDD:290200	12/22 (55%)
		zf-C2H2	439..461	CDD:278523	10/21 (48%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-C2H2	467..489	CDD:278523	5/21 (24%)
		C2H2 Zn finger	469..489	CDD:275368	5/19 (26%)
		C2H2 Zn finger	497..515	CDD:275368	7/28 (25%)
ZNF485	NP_001305069.1	KRAB	11..71	CDD:214630	13/60 (22%)
		KRAB	11..50	CDD:279668	10/39 (26%)
		COG5048	<124..361	CDD:227381	86/238 (36%)
		C2H2 Zn finger	132..152	CDD:275368	6/19 (32%)
		C2H2 Zn finger	160..180	CDD:275368	5/19 (26%)
		C2H2 Zn finger	188..208	CDD:275368	0/19 (0%)
		C2H2 Zn finger	216..236	CDD:275368	10/19 (53%)
		zf-H2C2_2	229..253	CDD:290200	11/23 (48%)
		C2H2 Zn finger	244..264	CDD:275368	8/19 (42%)
		zf-H2C2_2	256..279	CDD:290200	13/22 (59%)
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..307	CDD:290200	12/19 (63%)
		C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		zf-H2C2_2	313..337	CDD:290200	10/23 (43%)
		C2H2 Zn finger	328..348	CDD:275368	5/19 (26%)
		C2H2 Zn finger	356..376	CDD:275368	7/21 (33%)
		zf-H2C2_2	372..393	CDD:290200	4/20 (20%)
		C2H2 Zn finger	384..404	CDD:275368	6/14 (43%)
		zf-H2C2_2	397..419	CDD:290200	1/1 (100%)
		C2H2 Zn finger	412..432	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910