DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and Zfp719

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001344698.1	Gene:	Zfp719 / 210105	MGIID:	2444708	Length:	735	Species:	Mus musculus

Alignment Length:	604	Identity:	155/604 - (25%)
Similarity:	240/604 - (39%)	Gaps:	145/604 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLQRSYDLSPSPARTSPTNGVQNLGAGAQLPPAQVTDFSISKILGKERKSAQDTSTNILDLSKSS 65
            :|::.:......|:|...:.|..:..||         |...|||         |..:..|..::.
Mouse   124 VLEKLWQEGDPAAKTDQQSRVLPVSPGA---------FQNQKIL---------TIGSAWDYEETE 170

  Fly    66 SNSIRSPQALGGLAIPSTPYA-SGAYSMLPPDLVAMANATKFYAQFFPHLLPAYAAAAAAAGLST 129
            .:::..|..:....:|  |.| |.:.|.....|..:..:.:|:.|            |::.|:.|
Mouse   171 ESTLLEPHLISTQYVP--PRANSDSQSNTIKQLNDIIGSDQFFTQ------------ASSNGVCT 221

  Fly   130 PPTSPYQTHQHQQHLPNQQKRFFAPYVINGSVPPPPPLQQ-----QQQPLIRTKSTACTRPDCPE 189
            .|        ||...|..:.:|.....:|      |||..     |.:|:   :.|.|.:....|
Mouse   222 VP--------HQTEKPYTESQFGNIVSLN------PPLMDHEINFQDKPV---EYTGCGKVFTGE 269

  Fly   190 CLDYYQR----LQTGGYKQTAPLISPAASSVSSSTGSIR---PVR--DLIMSATGGAASTNISLT 245
            .....|:    ::|.....|........|.::|.:.:.|   |..  |...|..|   :|::.:.
Mouse   270 TAFCQQQITNSMETSFICHTCGKTFLHKSKLTSHSETPREETPYECPDCAKSLRG---TTSLQVL 331

  Fly   246 TVTNLSLNSVQATAVGMMPKMTGGL---ITTAVGSNSGAIGGIGGYNATSAEEI----------- 296
            ..........:....|.....|..|   :.|..|....|....|  .|.|.:.:
Mouse   332 RGVQTKEKPYECHVCGKSFSYTSHLKVHLRTHTGEKPYACSDCG--KAFSQKSVLTIHQRIHTGE 394

  Fly   297 -SYKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFS------------------------ 335
             .|.|..|.|:|.|:..|..|.:.|...: |||.||||.||
Mouse   395 KPYTCSDCGKMFVCASDLTKHCRFHTGEKPYECPDCGKSFSIKSNLLAHHRIHTSEGPYKCFHCG 459

  Fly   336 ----QLRNYKYHLSVHRGTKEFAAECPECGKTFNDKGYLSSHLKIHRNRKEYEC----------- 385
                ::...|.|..:|...:.|.  |.:||..|:.|..|::|.:||...|.|.|
Mouse   460 ESFRKISQLKVHHQIHTDRRSFV--CSDCGMAFSQKSVLTTHQRIHSGEKCYPCSDCGKLFLYAS 522

  Fly   386 -------------PY----CPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTH 433
                         ||    |.||::.:...::|.|||||.:|:||::|||.|.|...|:.|.:||
Mouse   523 DLKKHCRFHTGEKPYKCHDCGKSYSVKSHLHVHHRIHTGERPYKCDDCGKSFRRNSHLQMHQQTH 587

  Fly   434 SGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCP 498
            :|||||:||.|||||...|::.:|||:|:|.|||.|..|.|||..:..|.||...|||.|||:|
Mouse   588 TGEKPYKCSDCGKSFRRASHLKVHHRIHTGEKPFVCSECGKAFNDRSVLSTHQRIHTGEKPYIC- 651

  Fly   499 HPNCNQAFTQSSNMRTHAK 517
             .:|.:|.:..:|::.|.:
Mouse   652 -SDCGKAMSSKANLKEHQR 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	86/242 (36%)
		C2H2 Zn finger	327..347	CDD:275368	9/47 (19%)
		zf-C2H2	356..377	CDD:278523	7/20 (35%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	369..394	CDD:290200	12/52 (23%)
		C2H2 Zn finger	385..405	CDD:275368	8/47 (17%)
		zf-H2C2_2	397..422	CDD:290200	13/24 (54%)
		C2H2 Zn finger	413..433	CDD:275368	8/19 (42%)
		zf-H2C2_2	426..449	CDD:290200	15/22 (68%)
		zf-C2H2	439..461	CDD:278523	12/21 (57%)
		C2H2 Zn finger	441..461	CDD:275368	11/19 (58%)
		zf-C2H2	467..489	CDD:278523	9/21 (43%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	4/17 (24%)
Zfp719	NP_001344698.1	KRAB	48..89	CDD:396083
		C2H2 Zn finger	287..307	CDD:275368	3/19 (16%)
		C2H2 Zn finger	315..335	CDD:275368	4/22 (18%)
		COG5048	335..708	CDD:227381	106/341 (31%)
		C2H2 Zn finger	343..363	CDD:275368	3/19 (16%)
		C2H2 Zn finger	371..391	CDD:275368	3/21 (14%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		C2H2 Zn finger	427..447	CDD:275368	7/19 (37%)
		C2H2 Zn finger	455..475	CDD:275368	2/19 (11%)
		C2H2 Zn finger	483..503	CDD:275368	7/19 (37%)
		C2H2 Zn finger	511..531	CDD:275368	1/19 (5%)
		C2H2 Zn finger	539..559	CDD:275368	5/19 (26%)
		C2H2 Zn finger	567..587	CDD:275368	8/19 (42%)
		C2H2 Zn finger	595..615	CDD:275368	11/19 (58%)
		C2H2 Zn finger	623..643	CDD:275368	8/19 (42%)
		C2H2 Zn finger	651..671	CDD:275368	5/21 (24%)
		C2H2 Zn finger	679..699	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100