DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZNF721

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_597731.2	Gene:	ZNF721 / 170960	HGNCID:	29425	Length:	923	Species:	Homo sapiens

Alignment Length:	250	Identity:	100/250 - (40%)
Similarity:	128/250 - (51%)	Gaps:	29/250 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 EISYKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAAE-- 356
            |.||||..|.|.||.|..|..|:|.|...: |:|.:|||.||:.||...|..||...|.:..|
Human   666 EQSYKCEECGKAFGWSIALNQHKKIHTGEKPYKCEECGKAFSRSRNLTTHRRVHTREKPYKCEDR 730

  Fly   357 ------------------------CPECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVA 397
                                    |.||||.|....:|:.|.|||..:|.|:|..|.|......:
Human   731 GRSFGWSTNLNEYKKIHTGDKLYKCKECGKVFKQSSHLNRHEKIHTGKKPYKCKECGKVITSSSS 795

  Fly   398 FNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHS 462
            |..|.|||||.||.||.||||.|:....|.:|.|.|:|||||.|..|||:|...:.:.:|.|:|:
Human   796 FAKHKRIHTGEKPFKCLECGKAFTSSTTLTKHRRIHTGEKPYTCEECGKAFRQSAILYVHRRIHT 860

  Fly   463 GIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTHAK 517
            |.||::|..|.|.|.:..:|..|...|||.|||.|  .:|.:.|.||:|:..|.|
Human   861 GEKPYTCGECGKTFRQSANLYAHKKIHTGEKPYTC--GDCGKTFRQSANLYAHKK 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	9/19 (47%)
		COG5048	<316..502	CDD:227381	82/212 (39%)
		C2H2 Zn finger	327..347	CDD:275368	9/19 (47%)
		zf-C2H2	356..377	CDD:278523	10/46 (22%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	10/24 (42%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	16/24 (67%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..449	CDD:290200	13/22 (59%)
		zf-C2H2	439..461	CDD:278523	8/21 (38%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-C2H2	467..489	CDD:278523	6/21 (29%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..515	CDD:275368	6/17 (35%)
ZNF721	NP_597731.2	C2H2 Zn finger	83..103	CDD:275368
		COG5048	93..492	CDD:227381
		C2H2 Zn finger	111..131	CDD:275368
		C2H2 Zn finger	139..159	CDD:275368
		zf-H2C2_2	151..176	CDD:290200
		C2H2 Zn finger	167..187	CDD:275368
		C2H2 Zn finger	223..243	CDD:275368
		zf-H2C2_2	235..257	CDD:290200
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		zf-H2C2_2	292..316	CDD:290200
		C2H2 Zn finger	307..327	CDD:275368
		zf-H2C2_2	319..344	CDD:290200
		C2H2 Zn finger	335..355	CDD:275368
		zf-H2C2_2	347..372	CDD:290200
		C2H2 Zn finger	363..383	CDD:275368
		zf-H2C2_2	375..400	CDD:290200
		C2H2 Zn finger	391..411	CDD:275368
		COG5048	442..885	CDD:227381	86/218 (39%)
		C2H2 Zn finger	447..467	CDD:275368
		C2H2 Zn finger	475..495	CDD:275368
		zf-H2C2_2	487..512	CDD:290200
		C2H2 Zn finger	503..523	CDD:275368
		zf-H2C2_2	516..540	CDD:290200
		C2H2 Zn finger	531..551	CDD:275368
		zf-H2C2_2	544..568	CDD:290200
		C2H2 Zn finger	559..579	CDD:275368
		zf-H2C2_2	571..596	CDD:290200
		C2H2 Zn finger	587..607	CDD:275368
		C2H2 Zn finger	615..634	CDD:275368
		C2H2 Zn finger	643..663	CDD:275368
		C2H2 Zn finger	671..691	CDD:275368	9/19 (47%)
		zf-H2C2_2	683..708	CDD:290200	10/24 (42%)
		C2H2 Zn finger	699..719	CDD:275368	9/19 (47%)
		C2H2 Zn finger	755..775	CDD:275368	9/19 (47%)
		zf-H2C2_2	767..789	CDD:290200	9/21 (43%)
		C2H2 Zn finger	783..803	CDD:275368	6/19 (32%)
		zf-H2C2_2	795..820	CDD:290200	16/24 (67%)
		C2H2 Zn finger	811..831	CDD:275368	9/19 (47%)
		zf-H2C2_2	824..848	CDD:290200	14/23 (61%)
		C2H2 Zn finger	839..859	CDD:275368	7/19 (37%)
		zf-H2C2_2	852..876	CDD:290200	10/23 (43%)
		C2H2 Zn finger	867..887	CDD:275368	6/19 (32%)
		C2H2 Zn finger	895..915	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910