DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and Zfp287

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_573471.2	Gene:	Zfp287 / 170740	MGIID:	2176561	Length:	759	Species:	Mus musculus

Alignment Length:	565	Identity:	151/565 - (26%)
Similarity:	211/565 - (37%)	Gaps:	167/565 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LQRSYDLSPSPARTSP---TNGV-----QNLGAGAQLPPAQVTDFSISKI------------LGK 46
            |:.|||.....:..||   ..|:     :.....::|.....|:..:||.            ||.
Mouse   262 LEDSYDDDNDDSVESPPVCAFGMIHIDEEGFSVKSELSQEDPTEEYLSKCDIYRVTFEKHTNLGV 326

  Fly    47 ERKSAQDTSTNILDLSKSSSNSIRSPQALGGLAIP-STPYASGA----YSMLPPDLVAMANATKF 106
            :..:..|..|.:.:.||...::..|..|:.|..:| ..||:...    :...|..|....|..|.
Mouse   327 QFDTQSDDKTALYNESKPPFSNASSGGAVRGKILPGDKPYSCNVCGKQFRKYPSLLAHRENHAKE 391

  Fly   107 YA-------QFFPHLLPAYAAAAAAAGLSTPPTSPYQTHQ------HQQHLPNQQKRFFAPYVIN 158
            .|       :.|.||....|......|     ..||:.||      .:.||...|:      :..
Mouse   392 KAYECEECGKEFKHLSSLIAHQRMHTG-----EKPYECHQCGKAFSQRAHLTIHQR------IHT 445

  Fly   159 GSVPPPPPLQQQQQPLIRTKSTACTRPDCPEC-LDYYQRLQTGGYKQTAPLISPAASSVSSSTGS 222
            |..|                      ..|.:| .|:.||
Mouse   446 GEKP----------------------YKCEDCGKDFSQR-------------------------- 462

  Fly   223 IRPVRDLIMSATGGAASTNISLTTVTNLSLNSVQATAVGMMPKMTGGLITTAVGSNSGAIGGIGG 287
                                     .:|:::  |.|..|..|
Mouse   463 -------------------------AHLTIH--QRTHTGEKP----------------------- 477

  Fly   288 YNATSAEEISYKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTK 351
                      |||..|.|.|..|.:|..|::.|...: |.|.:|||.|||..:...|..:|.|.|
Mouse   478 ----------YKCLECSKTFSHSSSLINHQRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKK 532

  Fly   352 EFAAECPECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNEC 416
            .:  :|.||.|.|:...||..|.:||...|.|:|..|.|:|........|...|||.|.:.||.|
Mouse   533 PY--KCNECWKVFSQSTYLIRHQRIHSGEKCYKCTACGKAFAHSSTLIQHQTTHTGEKSYICNVC 595

  Fly   417 GKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHH 481
            ||.||:...|.||.|||:|||||:||||||:|:...::|.|.|:|:|.|||.|..|.||:.:..:
Mouse   596 GKAFSQSANLTQHHRTHTGEKPYKCSVCGKAFSQSVHLTQHQRIHNGEKPFKCNTCGKAYRQGAN 660

  Fly   482 LKTHLNYHTGCKPYVCPHPNCNQAFTQSSNM----RTHAKKCQYR 522
            |..|...|||.|||.|.|  |.:||..||::    |||..:..|:
Mouse   661 LTQHQRVHTGEKPYKCHH--CGKAFIYSSSLNQHRRTHTGERPYK 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	82/186 (44%)
		C2H2 Zn finger	327..347	CDD:275368	8/19 (42%)
		zf-C2H2	356..377	CDD:278523	8/20 (40%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	11/24 (46%)
		C2H2 Zn finger	385..405	CDD:275368	5/19 (26%)
		zf-H2C2_2	397..422	CDD:290200	11/24 (46%)
		C2H2 Zn finger	413..433	CDD:275368	11/19 (58%)
		zf-H2C2_2	426..449	CDD:290200	17/22 (77%)
		zf-C2H2	439..461	CDD:278523	11/21 (52%)
		C2H2 Zn finger	441..461	CDD:275368	10/19 (53%)
		zf-C2H2	467..489	CDD:278523	7/21 (33%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..515	CDD:275368	8/21 (38%)
Zfp287	NP_573471.2	SCAN	39..138	CDD:383046
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..154
		KRAB	166..223	CDD:214630
		C2H2 Zn finger	368..388	CDD:275368	2/19 (11%)
		zf-C2H2	394..416	CDD:333835	4/21 (19%)
		C2H2 Zn finger	396..416	CDD:275368	4/19 (21%)
		COG5048	420..753	CDD:227381	118/402 (29%)
		C2H2 Zn finger	424..444	CDD:275368	5/25 (20%)
		C2H2 Zn finger	452..472	CDD:275368	7/72 (10%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	536..556	CDD:275368	8/19 (42%)
		C2H2 Zn finger	564..584	CDD:275368	5/19 (26%)
		C2H2 Zn finger	592..612	CDD:275368	11/19 (58%)
		C2H2 Zn finger	620..640	CDD:275368	10/19 (53%)
		C2H2 Zn finger	648..668	CDD:275368	6/19 (32%)
		C2H2 Zn finger	676..696	CDD:275368	8/21 (38%)
		C2H2 Zn finger	704..724	CDD:275368	151/565 (27%)
		C2H2 Zn finger	732..752	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846076
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930