DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZNF679

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_699194.2	Gene:	ZNF679 / 168417	HGNCID:	28650	Length:	411	Species:	Homo sapiens

Alignment Length:	425	Identity:	132/425 - (31%)
Similarity:	183/425 - (43%)	Gaps:	65/425 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 FAPYVINGSVPPPPPLQQQQQPLIR-----------TKSTACTRPDCPECLDYYQRLQTGGYKQT 205
            |...||..|:.....|...||.|.|           :...|.::||...||:  |..:....|:.
Human    18 FRDVVIEFSLEEWQCLDHAQQNLYRDVMLENYRNLVSLGIAVSKPDLITCLE--QNKEPWNIKRN 80

  Fly   206 APLISPAASSVSSSTGSIRP---VRD----LIMSATGGAASTNISLTTVTNLSLNSVQATAVGMM 263
             .:::......|..|..:.|   ::|    :|....|.:...|:.:.|..::....||.
Human    81 -EMVTKHPVMCSHFTQDLPPELGIKDSLQKVIPRRYGKSGHDNLQVKTCKSMGECEVQK------ 138

  Fly   264 PKMTGGLITTAVGSNSGAIGGIGGYN---ATSAEEISYKCRICEKVFGCSETLQAHEKTHKSPR- 324
                               ||....|   :|:..:| ::...|.||||.......|:..|...:
Human   139 -------------------GGCNEVNQCLSTTQNKI-FQTHKCVKVFGKFSNSNRHKTRHTGKKH 183

  Fly   325 YECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPECGKTFNDKGYLSSHLKIHRNRKEYECPYCP 389
            ::|...||.|..:.....|..:|  |:|.:.:|.||||.||....||.|.:||...|.|.|..|.
Human   184 FKCKKYGKSFCMVSQLHQHQIIH--TRENSYQCEECGKPFNCSSTLSKHKRIHTGEKPYRCEECG 246

  Fly   390 KSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRSNM 454
            |:|........|.|||||.||:.|.|||:.|||...|..|.|.|:|||||.|..|||:|:..|::
Human   247 KAFTWSSTLTKHRRIHTGEKPYTCEECGQAFSRSSTLANHKRIHTGEKPYTCEECGKAFSLSSSL 311

  Fly   455 TLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTHAK-- 517
            |.|.|:|:|.||::|..|.|||.....||.|...|||.|||.|  ..|.:||..||.:.||.:
Human   312 TYHKRIHTGEKPYTCEECGKAFNCSSTLKKHKIIHTGEKPYKC--KECGKAFAFSSTLNTHKRIH 374

  Fly   518 ------KCQYRPLDGLTVTSSALPVPGKQQTGPPP 546
                  ||:  ..|.....||:|.......||..|
Human   375 TGEEPYKCE--ECDKAFKWSSSLANHKSMHTGEKP 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		COG5048	<316..502	CDD:227381	80/186 (43%)
		C2H2 Zn finger	327..347	CDD:275368	5/19 (26%)
		zf-C2H2	356..377	CDD:278523	10/20 (50%)
		C2H2 Zn finger	357..377	CDD:275368	10/19 (53%)
		zf-H2C2_2	369..394	CDD:290200	11/24 (46%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	13/24 (54%)
		C2H2 Zn finger	413..433	CDD:275368	10/19 (53%)
		zf-H2C2_2	426..449	CDD:290200	13/22 (59%)
		zf-C2H2	439..461	CDD:278523	10/21 (48%)
		C2H2 Zn finger	441..461	CDD:275368	9/19 (47%)
		zf-C2H2	467..489	CDD:278523	8/21 (38%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	6/17 (35%)
ZNF679	NP_699194.2	KRAB	16..76	CDD:214630	15/59 (25%)
		KRAB	16..55	CDD:279668	9/36 (25%)
		C2H2 Zn finger	159..178	CDD:275368	6/18 (33%)
		C2H2 Zn finger	186..206	CDD:275368	5/19 (26%)
		C2H2 Zn finger	214..234	CDD:275368	10/19 (53%)
		zf-H2C2_2	227..250	CDD:290200	10/22 (45%)
		COG5048	<238..401	CDD:227381	71/166 (43%)
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		zf-H2C2_2	255..279	CDD:290200	13/23 (57%)
		C2H2 Zn finger	270..290	CDD:275368	10/19 (53%)
		zf-H2C2_2	283..306	CDD:290200	13/22 (59%)
		C2H2 Zn finger	298..318	CDD:275368	9/19 (47%)
		zf-H2C2_2	310..335	CDD:290200	12/24 (50%)
		C2H2 Zn finger	326..346	CDD:275368	8/19 (42%)
		zf-H2C2_2	339..362	CDD:290200	12/24 (50%)
		C2H2 Zn finger	354..374	CDD:275368	8/21 (38%)
		zf-H2C2_2	367..390	CDD:290200	5/24 (21%)
		C2H2 Zn finger	382..402	CDD:275368	5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100