DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZNF100

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_775802.2	Gene:	ZNF100 / 163227	HGNCID:	12880	Length:	542	Species:	Homo sapiens

Alignment Length:	399	Identity:	126/399 - (31%)
Similarity:	167/399 - (41%)	Gaps:	79/399 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 LIRTKSTACTRPDCPECLDYYQRLQTGGYKQTAPLISP------------AASSVSSSTGSIRPV 226
            |:.....|.|:||...||:  |..:....|:...:..|            |...:..|      .
Human    71 LVFLAGIALTKPDLITCLE--QGKEPWNIKRHEMVAKPPVICSHFPQDLWAEQDIKDS------F 127

  Fly   227 RDLIMSATGGAASTNISLTTVTNLSLNSVQATAVGMM--PKMTGGLITTAVG------------- 276
            ::.|:...|.....|:.|    .....||....|...  .|:...||||...
Human   128 QEAILKKYGKYGHDNLQL----QKGCKSVDECKVHKEHDNKLNQCLITTQSNIFQCDPSAKVFHT 188

  Fly   277 -SNSGAIGGIGGYNATSAEEISYKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRN 339
             |||..      :......:..:||:.|||.|.....|..|::.|.:.. |:|.||||.|:....
Human   189 FSNSNR------HKIRHTRKKPFKCKKCEKSFCMLLHLTQHKRFHITENSYQCKDCGKAFNWFST 247

  Fly   340 YKYHLSVHRGTKEFAAECPECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRI 404
            ...|..:|.|.|.:  :|.||||.||...:|::|..||...|.|.|..|.|:||:......|.||
Human   248 LTTHRRIHTGEKPY--KCEECGKAFNRSSHLTTHKIIHTGEKPYRCEECGKAFNRSSHLTTHKRI 310

  Fly   405 HTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSC 469
            ||||||:||.||||.|:|...|..|...|:|||||:|..|||:|...|.:|.|...|:|.||:.|
Human   311 HTGVKPYKCTECGKAFNRSSHLTTHRIIHTGEKPYKCEECGKAFNQSSTLTTHKITHAGEKPYKC 375

  Fly   470 PLCPKAFTK-----KHH-----------------------LKTHLNYHTGCKPYVCPHPNCNQAF 506
            ..|.|||.:     ||.                       |..|...|||.|||.|  ..|.:||
Human   376 EECGKAFYRFSYLTKHKTSHTGEKFYKCEECGKGFNWSSALTKHKRIHTGEKPYKC--EECGKAF 438

  Fly   507 TQSSNMRTH 515
            .:|||:.||
Human   439 NESSNLTTH 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	84/214 (39%)
		C2H2 Zn finger	327..347	CDD:275368	7/19 (37%)
		zf-C2H2	356..377	CDD:278523	9/20 (45%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	10/24 (42%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	16/24 (67%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..449	CDD:290200	12/22 (55%)
		zf-C2H2	439..461	CDD:278523	9/21 (43%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-C2H2	467..489	CDD:278523	9/49 (18%)
		C2H2 Zn finger	469..489	CDD:275368	9/47 (19%)
		C2H2 Zn finger	497..515	CDD:275368	7/17 (41%)
ZNF100	NP_775802.2	KRAB	35..96	CDD:214630	8/26 (31%)
		KRAB	35..74	CDD:279668	1/2 (50%)
		COG5048	150..534	CDD:227381	110/308 (36%)
		C2H2 Zn finger	207..227	CDD:275368	7/19 (37%)
		C2H2 Zn finger	235..255	CDD:275368	7/19 (37%)
		zf-H2C2_2	248..272	CDD:290200	10/25 (40%)
		C2H2 Zn finger	263..283	CDD:275368	9/19 (47%)
		zf-H2C2_2	275..300	CDD:290200	10/24 (42%)
		C2H2 Zn finger	291..311	CDD:275368	7/19 (37%)
		zf-H2C2_2	303..328	CDD:290200	16/24 (67%)
		C2H2 Zn finger	319..339	CDD:275368	9/19 (47%)
		zf-H2C2_2	331..356	CDD:290200	13/24 (54%)
		C2H2 Zn finger	347..367	CDD:275368	8/19 (42%)
		C2H2 Zn finger	375..395	CDD:275368	7/19 (37%)
		C2H2 Zn finger	403..423	CDD:275368	2/19 (11%)
		zf-H2C2_2	415..439	CDD:290200	11/25 (44%)
		C2H2 Zn finger	431..451	CDD:275368	9/19 (47%)
		zf-H2C2_2	443..468	CDD:290200	3/5 (60%)
		C2H2 Zn finger	459..479	CDD:275368
		zf-H2C2_2	472..496	CDD:290200
		C2H2 Zn finger	487..507	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010