DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZNF782

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001001662.1	Gene:	ZNF782 / 158431	HGNCID:	33110	Length:	699	Species:	Homo sapiens

Alignment Length:	424	Identity:	138/424 - (32%)
Similarity:	194/424 - (45%)	Gaps:	68/424 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 GLSTPPTSPYQTHQHQQHLPNQQKRFFAPYVINGSVPPPPPLQQQQQPLIRTKSTACTRPDCPEC 190
            |.|....|..:.| |:.|:..:...:...:..|.::    |:.|      ||.:|       .:.
Human   291 GKSFSQKSHIREH-HRVHIGVKPFEYGKSFNRNSTL----PVHQ------RTHAT-------DKY 337

  Fly   191 LDYYQRLQTGGYKQTAPL------------ISPAASSVSSSTGSIRPVRDLIMSATG-------- 235
            .||:...:|..|:.|..:            .:....|.|.::..|.|.:    |.||
Human   338 SDYHPCTETFSYQSTFSVHQKVHIRAKPYEYNECGKSCSMNSHLIWPQK----SHTGEKPYECPE 398

  Fly   236 -GAASTNISLTTVTNLSLNSVQATAVGMMPKMTGGLITTAVGSNSGAIGGIGGYNATSAEEISYK 299
             |.|.:..|       .|...|.|..|..|....| ...|..:.|    |:..:..|...|..::
Human   399 CGKAFSEKS-------RLRKHQRTHTGEKPYKCDG-CDKAFSAKS----GLRIHQRTHTGEKPFE 451

  Fly   300 CRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPECGKT 363
            |..|.|.|.....|..|::||...: :||.:|||.||.:...:.|...|.|.:.:  :|.||||.
Human   452 CHECGKSFNYKSILIVHQRTHTGEKPFECNECGKSFSHMSGLRNHRRTHTGERPY--KCDECGKA 514

  Fly   364 FNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQ 428
            |..|..|..|.:.|...|.|:|..|.|:|.|:.....|.|||||.||:|||.||:.||:|..|:.
Human   515 FKLKSGLRKHHRTHTGEKPYKCNQCGKAFGQKSQLRGHHRIHTGEKPYKCNHCGEAFSQKSNLRV 579

  Fly   429 HMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCK 493
            |.|||:|||||||..|||:|..:||:..|.|.|:|.||:.|..|.|||::|..|:.|...|||.|
Human   580 HHRTHTGEKPYQCEECGKTFRQKSNLRGHQRTHTGEKPYECNECGKAFSEKSVLRKHQRTHTGEK 644

  Fly   494 PYVCPHPNCNQAFTQSSNMRTHAK--------KC 519
            ||.|  ..|.:||:|.||:|.|.:        ||
Human   645 PYNC--NQCGEAFSQKSNLRVHQRTHTGEKPYKC 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		COG5048	<316..502	CDD:227381	85/186 (46%)
		C2H2 Zn finger	327..347	CDD:275368	7/19 (37%)
		zf-C2H2	356..377	CDD:278523	9/20 (45%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	9/24 (38%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	14/24 (58%)
		C2H2 Zn finger	413..433	CDD:275368	10/19 (53%)
		zf-H2C2_2	426..449	CDD:290200	15/22 (68%)
		zf-C2H2	439..461	CDD:278523	11/21 (52%)
		C2H2 Zn finger	441..461	CDD:275368	9/19 (47%)
		zf-C2H2	467..489	CDD:278523	8/21 (38%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	8/17 (47%)
ZNF782	NP_001001662.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..95
		C2H2 Zn finger	291..307	CDD:275368	5/16 (31%)
		C2H2 Zn finger	314..332	CDD:275368	4/27 (15%)
		C2H2 Zn finger	343..360	CDD:275368	3/16 (19%)
		C2H2 Zn finger	369..388	CDD:275368	4/22 (18%)
		COG5048	392..697	CDD:227381	114/301 (38%)
		C2H2 Zn finger	396..416	CDD:275368	5/26 (19%)
		zf-H2C2_2	409..432	CDD:290200	7/23 (30%)
		C2H2 Zn finger	424..444	CDD:275368	4/24 (17%)
		zf-H2C2_2	437..461	CDD:290200	6/23 (26%)
		C2H2 Zn finger	452..472	CDD:275368	6/19 (32%)
		zf-H2C2_2	465..489	CDD:290200	10/23 (43%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		zf-H2C2_2	493..516	CDD:290200	8/24 (33%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		zf-H2C2_2	521..543	CDD:290200	8/21 (38%)
		C2H2 Zn finger	536..556	CDD:275368	7/19 (37%)
		zf-H2C2_2	549..573	CDD:290200	14/23 (61%)
		C2H2 Zn finger	564..584	CDD:275368	10/19 (53%)
		zf-H2C2_2	576..601	CDD:290200	16/24 (67%)
		C2H2 Zn finger	592..612	CDD:275368	9/19 (47%)
		zf-H2C2_2	604..628	CDD:290200	11/23 (48%)
		C2H2 Zn finger	620..640	CDD:275368	8/19 (42%)
		zf-H2C2_2	633..657	CDD:290200	12/25 (48%)
		C2H2 Zn finger	648..668	CDD:275368	9/21 (43%)
		zf-H2C2_2	660..685	CDD:290200	5/17 (29%)
		C2H2 Zn finger	676..696	CDD:275368	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910