DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZFP28

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_065879.1	Gene:	ZFP28 / 140612	HGNCID:	17801	Length:	868	Species:	Homo sapiens

Alignment Length:	554	Identity:	146/554 - (26%)
Similarity:	210/554 - (37%)	Gaps:	153/554 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 SGAYSMLPPDLVAMANATKFYAQFFPHLLPAYAAAAAAAGLSTPPTSPYQTHQHQQHLPNQ---- 147
            |..:.:..||||::....|     .|.::......:..:|..:       .|:.|:..|.|
Human   266 SAGHCVAKPDLVSLLEQEK-----EPWMVKRELTGSLFSGQRS-------VHETQELFPKQDSYA 318

  Fly   148 -----------------QKRFFAPYVINGSVPPPPPLQQQQQPLIRTKSTACTRP---------- 185
                             ::.:.:.||....:......|.:|:|:...|:.:..|.
Human   319 EGVTDRTSNTKLDCSSFRENWDSDYVFGRKLAVGQETQFRQEPITHNKTLSKERERTYNKSGRWF 383

  Fly   186 -------------------------------------DCPEC---------LDYYQRLQTGGYKQ 204
                                                 .|.||         |..:||:.||....
Human   384 YLDDSEEKVHNRDSIKNFQKSSVVIKQTGIYAGKKLFKCNECKKTFTQSSSLTVHQRIHTGEKPY 448

  Fly   205 TAPLISPAASSVSS-------STGSIRPVRDLIMSATGGAASTNISL------------------ 244
            .......|.|..||       .||. :|...:   ..|.|...|.||
Human   449 KCNECGKAFSDGSSFARHQRCHTGK-KPYECI---ECGKAFIQNTSLIRHWRYYHTGEKPFDCID 509

  Fly   245 ---TTVTNLSLNSVQATAVGMMPKMT---------GGLITTAVGSNSGAIGGIGGYNATSAEEIS 297
               ....::.||..:....|..|...         |..:|.....::|              |..
Human   510 CGKAFSDHIGLNQHRRIHTGEKPYKCDVCHKSFRYGSSLTVHQRIHTG--------------EKP 560

  Fly   298 YKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPECG 361
            |:|.:|.|.|....:|..|::.|...: ::|.:|||.|.|..:...||.:|.|.|.|  ||.|||
Human   561 YECDVCRKAFSHHASLTQHQRVHSGEKPFKCKECGKAFRQNIHLASHLRIHTGEKPF--ECAECG 623

  Fly   362 KTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLL 426
            |:|:....|::|.:||...|.|||..|.|:|.|:.....|.:.|||.||::|.||||.||:...|
Human   624 KSFSISSQLATHQRIHTGEKPYECKVCSKAFTQKAHLAQHQKTHTGEKPYECKECGKAFSQTTHL 688

  Fly   427 KQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTG 491
            .||.|.|:|||||:|..|||:|.|.|:.|.|.|||:|.:|:.|..|.|||..|..|..|...|||
Human   689 IQHQRVHTGEKPYKCMECGKAFGDNSSCTQHQRLHTGQRPYECIECGKAFKTKSSLICHRRSHTG 753

  Fly   492 CKPYVCPHPNCNQAFTQ----SSNMRTHAKKCQY 521
            .|||.|  ..|.:||:.    |.:.|.|:.|..|
Human   754 EKPYEC--SVCGKAFSHRQSLSVHQRIHSGKKPY 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		COG5048	<316..502	CDD:227381	85/186 (46%)
		C2H2 Zn finger	327..347	CDD:275368	8/19 (42%)
		zf-C2H2	356..377	CDD:278523	9/20 (45%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	11/24 (46%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	12/24 (50%)
		C2H2 Zn finger	413..433	CDD:275368	11/19 (58%)
		zf-H2C2_2	426..449	CDD:290200	14/22 (64%)
		zf-C2H2	439..461	CDD:278523	11/21 (52%)
		C2H2 Zn finger	441..461	CDD:275368	10/19 (53%)
		zf-C2H2	467..489	CDD:278523	8/21 (38%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	6/21 (29%)
ZFP28	NP_065879.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82
		KRAB	103..163	CDD:214630
		KRAB	103..142	CDD:279668
		KRAB	232..288	CDD:214630	7/26 (27%)
		KRAB	232..266	CDD:279668	146/554 (26%)
		COG5048	417..806	CDD:227381	127/391 (32%)
		zf-C2H2	420..442	CDD:278523	6/21 (29%)
		C2H2 Zn finger	422..442	CDD:275368	6/19 (32%)
		zf-H2C2_2	434..458	CDD:290200	6/23 (26%)
		C2H2 Zn finger	450..470	CDD:275368	4/19 (21%)
		zf-H2C2_2	462..487	CDD:290200	6/28 (21%)
		C2H2 Zn finger	478..496	CDD:275368	5/20 (25%)
		C2H2 Zn finger	507..527	CDD:275368	2/19 (11%)
		zf-H2C2_2	520..544	CDD:290200	4/23 (17%)
		C2H2 Zn finger	535..555	CDD:275368	2/19 (11%)
		zf-H2C2_2	547..572	CDD:290200	8/38 (21%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		zf-H2C2_2	575..600	CDD:290200	8/24 (33%)
		C2H2 Zn finger	591..611	CDD:275368	8/19 (42%)
		zf-H2C2_2	603..627	CDD:290200	12/25 (48%)
		C2H2 Zn finger	619..639	CDD:275368	8/19 (42%)
		zf-H2C2_2	632..656	CDD:290200	11/23 (48%)
		C2H2 Zn finger	647..667	CDD:275368	6/19 (32%)
		zf-H2C2_2	659..684	CDD:290200	12/24 (50%)
		C2H2 Zn finger	675..695	CDD:275368	11/19 (58%)
		zf-H2C2_2	687..710	CDD:290200	14/22 (64%)
		C2H2 Zn finger	703..723	CDD:275368	10/19 (53%)
		zf-H2C2_2	718..740	CDD:290200	11/21 (52%)
		C2H2 Zn finger	731..751	CDD:275368	8/19 (42%)
		zf-H2C2_2	743..768	CDD:290200	12/26 (46%)
		C2H2 Zn finger	759..779	CDD:275368	6/21 (29%)
		zf-H2C2_2	771..796	CDD:290200	5/15 (33%)
		C2H2 Zn finger	787..807	CDD:275368
		C2H2 Zn finger	815..835	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910