DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZNF786

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_689624.2	Gene:	ZNF786 / 136051	HGNCID:	21806	Length:	782	Species:	Homo sapiens

Alignment Length:	230	Identity:	86/230 - (37%)
Similarity:	127/230 - (55%)	Gaps:	10/230 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 EISYKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAAECP 358
            |..::|..|:|.|.....|:||:.||...| :.|.:|||||::......||.||.|.:.|  :||
Human   534 ERPFQCLKCDKRFRLKGILKAHQHTHSKERPFSCGECGKGFTRQSKLTEHLRVHSGERPF--QCP 596

  Fly   359 ECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRK 423
            ||.::|..||.|.||.::|...:.::||.|.|.:..:.....|..:|:|..|..| ||||.|.:.
Human   597 ECNRSFRLKGQLLSHQRLHTGERPFQCPECDKRYRVKADMKAHQLLHSGEMPFSC-ECGKGFVKH 660

  Fly   424 MLLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNY 488
            ..|.:|:|||:||||:||..|.|||..::.:..|..||:|.:||.||.|.|.|.::.|:..|...
Human   661 SKLIEHIRTHTGEKPFQCPKCDKSFRLKAQLLSHQGLHTGERPFHCPECDKNFRERGHMLRHQRI 725

  Fly   489 HTGCKPYVCPHPNCNQAFTQSS----NMRTHAKKC 519
            |...:|:.|  .:|.:.|...|    ::|.|.|.|
Human   726 HRPERPFAC--GDCGKGFIYKSKLAEHIRVHTKSC 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	72/186 (39%)
		C2H2 Zn finger	327..347	CDD:275368	8/19 (42%)
		zf-C2H2	356..377	CDD:278523	10/20 (50%)
		C2H2 Zn finger	357..377	CDD:275368	10/19 (53%)
		zf-H2C2_2	369..394	CDD:290200	8/24 (33%)
		C2H2 Zn finger	385..405	CDD:275368	5/19 (26%)
		zf-H2C2_2	397..422	CDD:290200	10/24 (42%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..449	CDD:290200	14/22 (64%)
		zf-C2H2	439..461	CDD:278523	7/21 (33%)
		C2H2 Zn finger	441..461	CDD:275368	6/19 (32%)
		zf-C2H2	467..489	CDD:278523	8/21 (38%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..515	CDD:275368	5/21 (24%)
ZNF786	NP_689624.2	KRAB	9..67	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..164
		C2H2 Zn finger	242..262	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..364
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		COG5048	<471..722	CDD:227381	75/190 (39%)
		C2H2 Zn finger	483..503	CDD:275368
		C2H2 Zn finger	511..531	CDD:275368
		C2H2 Zn finger	539..559	CDD:275368	7/19 (37%)
		C2H2 Zn finger	567..587	CDD:275368	8/19 (42%)
		C2H2 Zn finger	595..615	CDD:275368	10/19 (53%)
		C2H2 Zn finger	623..643	CDD:275368	5/19 (26%)
		C2H2 Zn finger	652..670	CDD:275368	8/17 (47%)
		C2H2 Zn finger	678..698	CDD:275368	6/19 (32%)
		C2H2 Zn finger	706..726	CDD:275368	7/19 (37%)
		C2H2 Zn finger	734..754	CDD:275368	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910