DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and AgaP_AGAP011759

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_320751.4	Gene:	AgaP_AGAP011759 / 1280881	VectorBaseID:	AGAP011759	Length:	830	Species:	Anopheles gambiae

Alignment Length:	599	Identity:	150/599 - (25%)
Similarity:	214/599 - (35%)	Gaps:	177/599 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 FYAQFFPHL-------------------LPAYAAAAAAAGLSTPPTSPYQTHQHQQHLPNQQKRF 151
            |||..||::                   ||.:.....|..|........:...:.:.|.|....|
Mosquito    39 FYANLFPNILLTKKIYDCTSIQIIYERNLPMFVCKLCANKLDEYVRFRDRCIANDEFLRNALAAF 103

  Fly   152 FAPYVING------------------SVPPPPPLQ------------QQQQPLIRTKSTACTRPD 186
            .|    ||                  :|||.||..            :....|:...:.|..:.:
Mosquito   104 DA----NGGGSCPGAIKMEPDDTAHPAVPPQPPASAKFAQCLAVTPLELNCALVEAAAAAAGKRE 164

  Fly   187 CPECLDYYQRLQTGGYKQTAPLISPAASSVSSSTGSIRPVRDLIMSATGGAASTNISLTTVTNLS 251
            .|   |..:..:..||              ...:|:..|.|    ||.|          .|..|:
Mosquito   165 PP---DIEEEDEERGY--------------GHGSGAPSPDR----SACG----------RVDELT 198

  Fly   252 LNSVQATAVGMMPKMTGGLITTAVGSNSGAIGGIGGYNATSAEEISYKCRICEKVFGCSETLQAH 316
            :....:..    |....|.....:.::.|..|......|..|::..|.|.:|.|.|.....|..|
Mosquito   199 VKRPHSDE----PHYHSGDEDDELLADDGYDGEPNQTPAEHADQQQYVCEVCSKSFKIRHHLLVH 259

  Fly   317 EKTHKSPRYECADC------------GKGFSQLRNYKYHLSVHRGTKEFAAECPECGKTFNDKGY 369
            ..||.......||.            |.|.:             |.|. :..||:|.|.|.:||.
Mosquito   260 RHTHVDSHAPTADMLHERADFNGATPGAGGA-------------GGKP-SYSCPKCPKAFVNKGN 310

  Fly   370 LSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHS 434
            |.:||:.|.:.|.|.|..|.|:|...|...:|:|||||.:||||..|.:.||:...|:.|.:|||
Mosquito   311 LLNHLETHTHEKSYACDICTKTFKYNVQLRLHMRIHTGERPHKCEICNRGFSQLSNLRSHRKTHS 375

  Fly   435 GEKPY---------------------------QCSVCGKSFADRSNMTLHHRLHS-GI--KPFSC 469
            ..|||                           :|::|.||||...|:..|.:.|| ||  |.|.|
Mosquito   376 KVKPYKCHLCLKSFTMLDNLTAHSAKCLKDKFRCTLCSKSFAKEGNLLSHLQSHSDGIVEKMFKC 440

  Fly   470 PLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTHAK------------KC--Q 520
            .:|||:|..|...|.|:..|||.|||.|  ..|::.|.|.:|:.:|.|            :|  .
Mosquito   441 EMCPKSFKNKEDWKRHVRVHTGEKPYTC--DICSKGFAQKANLLSHRKTHLKPNVTYSCDRCART 503

  Fly   521 YRPLDGLTV-----TSSALPVPGKQQTGPPPTLAMAMAQTFQMPPPPGV---LTPGSGP------ 571
            :|....|.:     |..|.|:.|  .:.||......::::....|.||.   ||..|..
Mosquito   504 FRSQKVLQMHVPKCTGGAGPIEG--ASVPPSAPVTPVSESIPDSPSPGAGVSLTTTSSSAVEAAA 566

  Fly   572 -SQPPSQQTLLSNL 584
             |.||:....||:|
Mosquito   567 NSTPPTLSEALSDL 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		COG5048	<316..502	CDD:227381	77/227 (34%)
		C2H2 Zn finger	327..347	CDD:275368	4/31 (13%)
		zf-C2H2	356..377	CDD:278523	10/20 (50%)
		C2H2 Zn finger	357..377	CDD:275368	10/19 (53%)
		zf-H2C2_2	369..394	CDD:290200	10/24 (42%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	12/24 (50%)
		C2H2 Zn finger	413..433	CDD:275368	6/19 (32%)
		zf-H2C2_2	426..449	CDD:290200	12/49 (24%)
		zf-C2H2	439..461	CDD:278523	9/48 (19%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-C2H2	467..489	CDD:278523	9/21 (43%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	5/17 (29%)
AgaP_AGAP011759	XP_320751.4	zf-AD	24..98	CDD:214871	10/58 (17%)
		C2H2 Zn finger	243..263	CDD:275368	6/19 (32%)
		C2H2 Zn finger	298..318	CDD:275368	10/19 (53%)
		C2H2 Zn finger	326..346	CDD:275368	7/19 (37%)
		zf-H2C2_2	339..363	CDD:290200	12/23 (52%)
		COG5048	<351..513	CDD:227381	53/163 (33%)
		C2H2 Zn finger	354..374	CDD:275368	6/19 (32%)
		zf-H2C2_2	366..390	CDD:290200	8/23 (35%)
		C2H2 Zn finger	382..398	CDD:275368	0/15 (0%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
		C2H2 Zn finger	440..460	CDD:275368	8/19 (42%)
		zf-H2C2_2	452..477	CDD:290200	11/26 (42%)
		C2H2 Zn finger	468..488	CDD:275368	7/21 (33%)
		C2H2 Zn finger	497..514	CDD:275368	3/16 (19%)
		C2H2 Zn finger	623..643	CDD:275368
		C2H2 Zn finger	722..742	CDD:275368
		C2H2 Zn finger	750..770	CDD:275368
		C2H2 Zn finger	780..800	CDD:275368
		zf-H2C2_2	792..817	CDD:290200
		C2H2 Zn finger	808..828	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910