DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZNF660-ZNF197

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001338661.1	Gene:	ZNF660-ZNF197 / 110354863	-ID:	-	Length:	1029	Species:	Homo sapiens

Alignment Length:	253	Identity:	100/253 - (39%)
Similarity:	134/253 - (52%)	Gaps:	33/253 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 EEISYKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAAEC 357
            :|.:|||..|.|.|..:.:|..|.:.|...: :||::||:.||..||...|..:|.|.|.:  ||
Human   730 QEKAYKCEDCGKAFSYNSSLLVHRRIHTGEKPFECSECGRAFSSNRNLIEHKRIHSGEKPY--EC 792

  Fly   358 PECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFS- 421
            .||||.|..|..|..|.:||...|.|:|..|.|.|:.|.....|.|||||.||:.|:||||.|:
Human   793 DECGKCFILKKSLIGHQRIHTREKSYKCNDCGKVFSYRSNLIAHQRIHTGEKPYACSECGKGFTY 857

  Fly   422 ----------------------RKML-----LKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHR 459
                                  ||:|     |..|.|.|:|||||:|:.|||.|:...|:.:|.|
Human   858 NRNLIEHQRIHSGEKTYECHVCRKVLTSSRNLMVHQRIHTGEKPYKCNECGKDFSQNKNLVVHQR 922

  Fly   460 LHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTHAK 517
            :|:|.||:.|..|.|:||.|.:|..|...|||.|||.|  .:|::.|.|..|:..|.|
Human   923 MHTGEKPYECDKCRKSFTSKRNLVGHQRIHTGEKPYGC--NDCSKVFRQRKNLTVHQK 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		COG5048	<316..502	CDD:227381	86/214 (40%)
		C2H2 Zn finger	327..347	CDD:275368	8/19 (42%)
		zf-C2H2	356..377	CDD:278523	10/20 (50%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	10/24 (42%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	14/47 (30%)
		C2H2 Zn finger	413..433	CDD:275368	12/47 (26%)
		zf-H2C2_2	426..449	CDD:290200	13/22 (59%)
		zf-C2H2	439..461	CDD:278523	9/21 (43%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-C2H2	467..489	CDD:278523	8/21 (38%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	5/17 (29%)
ZNF660-ZNF197	NP_001338661.1	SCAN	38..150	CDD:128708
		KRAB	216..256	CDD:307490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..290
		C2H2 Zn finger	372..392	CDD:275368
		zf-H2C2_2	384..409	CDD:316026
		C2H2 Zn finger	400..420	CDD:275368
		COG5048	424..853	CDD:227381	52/124 (42%)
		C2H2 Zn finger	428..448	CDD:275368
		C2H2 Zn finger	456..476	CDD:275368
		C2H2 Zn finger	484..504	CDD:275368
		C2H2 Zn finger	512..532	CDD:275368
		C2H2 Zn finger	540..560	CDD:275368
		C2H2 Zn finger	568..588	CDD:275368
		C2H2 Zn finger	596..616	CDD:275368
		C2H2 Zn finger	624..644	CDD:275368
		C2H2 Zn finger	652..672	CDD:275368
		C2H2 Zn finger	680..700	CDD:275368
		C2H2 Zn finger	708..728	CDD:275368
		C2H2 Zn finger	736..756	CDD:275368	6/19 (32%)
		COG5048	760..>1026	CDD:227381	90/223 (40%)
		C2H2 Zn finger	764..784	CDD:275368	8/19 (42%)
		C2H2 Zn finger	792..812	CDD:275368	9/19 (47%)
		C2H2 Zn finger	820..840	CDD:275368	7/19 (37%)
		C2H2 Zn finger	848..868	CDD:275368	6/19 (32%)
		C2H2 Zn finger	876..896	CDD:275368	6/19 (32%)
		C2H2 Zn finger	904..924	CDD:275368	8/19 (42%)
		C2H2 Zn finger	932..952	CDD:275368	8/19 (42%)
		C2H2 Zn finger	960..980	CDD:275368	7/21 (33%)
		C2H2 Zn finger	988..1008	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910