DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and Mzf1

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_006539528.1	Gene:	Mzf1 / 109889	MGIID:	107457	Length:	814	Species:	Mus musculus

Alignment Length:	632	Identity:	155/632 - (24%)
Similarity:	235/632 - (37%)	Gaps:	201/632 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SPSPARTSPTNGVQNLGAGAQLPPAQVTDFSISKILGKER-------KSAQDTSTNIL------- 59
            :|.|...:|...:|.|  ...||..:.|:     :||...       .:||:.:..:|
Mouse   242 TPDPGAETPQGAMQEL--PLNLPMKEETE-----LLGNPELLESGPLPAAQEAAATLLPKETQGH 299

  Fly    60 --DLSKSSSNSIRSP--------------QALGGLAIPSTPYASGAYSMLPPDLVAMANATKFYA 108
              .|.::|.:|...|              :.:||:..|.......:.: ..||:::
Mouse   300 GTTLDQTSPHSDTEPDVPPWSEDPMPLWHEEVGGIFSPGFTLQMDSIT-AEPDMMS--------- 354

  Fly   109 QFFPHL-LPAYAAAAAAAGLSTPPTSPYQTHQHQQHLPNQQKRFFAPYVINGSVPPPPPLQQQQQ 172
               ||| :|.....|:.:|....||:               :..||..::   :|..|  ..:|.
Mouse   355 ---PHLHVPWDLDMASLSGQIQSPTT---------------EGGFAHALV---LPSDP--GGEQD 396

  Fly   173 PLIRTKSTACTRPDCPECLDYYQRLQTGGYKQTAPLI------SPAASSVS---SSTGSIRPVRD 228
            |       ||..| ||               ...|.:      :|...|.|   |.||::|..|
Mouse   397 P-------ACEDP-CP---------------SVGPALVATRWHAPRGRSQSHPRSGTGAMRGGR- 437

  Fly   229 LIMSATGGAASTNISLTTVTNLSLNSVQATAVGMMPKMTGGLITTAVGSNSGAIGGIGGYNATSA 293
              ....|...|..      :||..:  |....|..|.:.|     ..|.:......:..:..|..
Mouse   438 --CDVCGKVFSQR------SNLLRH--QKIHTGERPFVCG-----ECGRSFSRSSHLLRHQLTHT 487

  Fly   294 EEISYKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKY--------------- 342
            ||..:.||.|.:.|..|..|:.|.:.|...: :.|.:||:.|.|..|...
Mouse   488 EERPFVCRDCGQGFVRSARLEEHRRVHTGEQPFRCTECGQSFRQRSNLLQHQRIHGDPPGPAPSI 552

  Fly   343 ------------------------------HLSVHRGTKEFAA---------------------- 355
                                          |.:||.|.|.|..
Mouse   553 LPLAGVPEPPGPFPCSECCESFPRRAVLLEHQAVHTGDKSFGCVECGERFGRRSVLLQHRRVHSG 617

  Fly   356 ----ECPECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNEC 416
                .|.|||::|..:..|:.|.:||...:.:.|..|.|:|.||.....|:|:|||.||..|.||
Mouse   618 ERPFACAECGQSFRQRSNLTQHQRIHTGERPFACAECGKTFRQRPTLTQHLRVHTGEKPFACPEC 682

  Fly   417 GKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHH 481
            |:|||:::.|.:|.|||:|||||.|..||..|...|.:|.|.|:|:|.:||:||.|.::|.:..:
Mouse   683 GQRFSQRLKLTRHQRTHTGEKPYCCGECGLGFTQVSRLTEHQRIHTGERPFACPECGQSFRQHAN 747

  Fly   482 LKTHLNYHTGCKPYVCPHPNCNQAFTQ----SSNMRTHAKK----CQ 520
            |..|...|||.:||.|  |.|.:||.|    :.::|||..:    ||
Mouse   748 LTQHRRIHTGERPYAC--PECGKAFRQRPTLTQHLRTHRHEKPFACQ 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	78/257 (30%)
		C2H2 Zn finger	327..347	CDD:275368	7/64 (11%)
		zf-C2H2	356..377	CDD:278523	7/20 (35%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	369..394	CDD:290200	8/24 (33%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	397..422	CDD:290200	13/24 (54%)
		C2H2 Zn finger	413..433	CDD:275368	10/19 (53%)
		zf-H2C2_2	426..449	CDD:290200	13/22 (59%)
		zf-C2H2	439..461	CDD:278523	9/21 (43%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-C2H2	467..489	CDD:278523	7/21 (33%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..515	CDD:275368	7/21 (33%)
Mzf1	XP_006539528.1	SCAN	121..232	CDD:128708
		COG5048	416..807	CDD:227381	113/395 (29%)
		C2H2 Zn finger	438..458	CDD:275368	5/27 (19%)
		C2H2 Zn finger	466..486	CDD:275368	2/24 (8%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		C2H2 Zn finger	522..542	CDD:275370	6/19 (32%)
		C2H2 Zn finger	567..587	CDD:275368	1/19 (5%)
		C2H2 Zn finger	595..615	CDD:275368	0/19 (0%)
		C2H2 Zn finger	623..643	CDD:275368	7/19 (37%)
		C2H2 Zn finger	651..671	CDD:275368	8/19 (42%)
		C2H2 Zn finger	679..699	CDD:275368	10/19 (53%)
		C2H2 Zn finger	707..727	CDD:275368	8/19 (42%)
		C2H2 Zn finger	735..755	CDD:275368	6/19 (32%)
		C2H2 Zn finger	763..783	CDD:275368	7/21 (33%)
		C2H2 Zn finger	791..811	CDD:275368	2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100