DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZNF268

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001159353.1	Gene:	ZNF268 / 10795	HGNCID:	13061	Length:	947	Species:	Homo sapiens

Alignment Length:	368	Identity:	116/368 - (31%)
Similarity:	156/368 - (42%)	Gaps:	80/368 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 DCPEC---------LDYYQRLQTG--GYKQTAPLISPAASSVSSSTGSIRPVRDLIMSATGGAAS 239
            :|.||         |..:||:.||  .|:             ....|.:...:|.::|.
Human   333 ECSECRKTFSFHSQLVIHQRIHTGENPYE-------------CCECGKVFSRKDQLVSH------ 378

  Fly   240 TNISLTTVTNLSLNSVQATAVGMMPKMTGGLITTAVGSNSGAIGGIGGYNATSAEEISYKCRICE 304
                            |.|..|..|     .:....|...|....:..:......|..|:|..|:
Human   379 ----------------QKTHSGQKP-----YVCNECGKAFGLKSQLIIHERIHTGEKPYECNECQ 422

  Fly   305 KVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAA------------- 355
            |.|.....|..|::||...: |.|:||||.|:.......|..:|.|.|.:..
Human   423 KAFNTKSNLMVHQRTHTGEKPYVCSDCGKAFTFKSQLIVHQGIHTGVKPYGCIQCGKGFSLKSQL 487

  Fly   356 -------------ECPECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTG 407
                         .|.||||.|..|.||..|.:.|...|.:||..|.|:|:.:....:|.|||||
Human   488 IVHQRSHTGMKPYVCNECGKAFRSKSYLIIHTRTHTGEKLHECNNCGKAFSFKSQLIIHQRIHTG 552

  Fly   408 VKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLC 472
            ..|::|:||||.||||..|..|.|||:|||||:|:.|||:|..:|.:.:|.|.|:|.|||.|..|
Human   553 ENPYECHECGKAFSRKYQLISHQRTHAGEKPYECTDCGKAFGLKSQLIIHQRTHTGEKPFECSEC 617

  Fly   473 PKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTH 515
            .|||..|.:|..|...|||.|||.|  ..|.:|||..|.:..|
Human   618 QKAFNTKSNLIVHQRTHTGEKPYSC--NECGKAFTFKSQLIVH 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		COG5048	<316..502	CDD:227381	85/212 (40%)
		C2H2 Zn finger	327..347	CDD:275368	7/19 (37%)
		zf-C2H2	356..377	CDD:278523	10/20 (50%)
		C2H2 Zn finger	357..377	CDD:275368	10/19 (53%)
		zf-H2C2_2	369..394	CDD:290200	10/24 (42%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	13/24 (54%)
		C2H2 Zn finger	413..433	CDD:275368	12/19 (63%)
		zf-H2C2_2	426..449	CDD:290200	14/22 (64%)
		zf-C2H2	439..461	CDD:278523	9/21 (43%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-C2H2	467..489	CDD:278523	9/21 (43%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	6/17 (35%)
ZNF268	NP_001159353.1	KRAB	81..141	CDD:214630
		KRAB	81..120	CDD:279668
		C2H2 Zn finger	278..298	CDD:275368
		C2H2 Zn finger	306..326	CDD:275368
		C2H2 Zn finger	334..354	CDD:275368	6/19 (32%)
		zf-H2C2_2	347..371	CDD:290200	7/36 (19%)
		C2H2 Zn finger	362..382	CDD:275368	4/41 (10%)
		zf-H2C2_2	375..397	CDD:290200	6/48 (13%)
		C2H2 Zn finger	390..410	CDD:275368	2/19 (11%)
		zf-H2C2_2	403..427	CDD:290200	6/23 (26%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-H2C2_2	430..454	CDD:290200	10/23 (43%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..494	CDD:275368	0/19 (0%)
		COG5048	497..910	CDD:227381	77/164 (47%)
		C2H2 Zn finger	502..522	CDD:275368	10/19 (53%)
		C2H2 Zn finger	530..550	CDD:275368	6/19 (32%)
		zf-H2C2_2	543..567	CDD:290200	13/23 (57%)
		zf-C2H2	556..578	CDD:278523	12/21 (57%)
		C2H2 Zn finger	558..578	CDD:275368	12/19 (63%)
		C2H2 Zn finger	586..606	CDD:275368	8/19 (42%)
		zf-H2C2_2	599..623	CDD:290200	12/23 (52%)
		C2H2 Zn finger	614..634	CDD:275368	8/19 (42%)
		zf-H2C2_2	626..650	CDD:290200	11/25 (44%)
		C2H2 Zn finger	642..662	CDD:275368	7/19 (37%)
		C2H2 Zn finger	670..690	CDD:275368
		C2H2 Zn finger	698..718	CDD:275368
		zf-H2C2_2	710..734	CDD:290200
		C2H2 Zn finger	726..746	CDD:275368
		zf-H2C2_2	739..763	CDD:290200
		C2H2 Zn finger	754..774	CDD:275368
		C2H2 Zn finger	782..802	CDD:275368
		zf-H2C2_2	794..817	CDD:290200
		C2H2 Zn finger	810..830	CDD:275368
		C2H2 Zn finger	838..858	CDD:275368
		zf-H2C2_2	851..875	CDD:290200
		C2H2 Zn finger	866..886	CDD:275368
		C2H2 Zn finger	894..914	CDD:275368
		zf-H2C2_2	907..929	CDD:290200
		C2H2 Zn finger	922..942	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910