DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and si:zfos-932h1.3

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_021330860.1	Gene:	si:zfos-932h1.3 / 100329491	ZFINID:	ZDB-GENE-141222-4	Length:	949	Species:	Danio rerio

Alignment Length:	596	Identity:	155/596 - (26%)
Similarity:	222/596 - (37%)	Gaps:	122/596 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QRSYDLSPSPARTSP---TNGVQNLGAG---AQLPPAQV---------TDFSISKILGKERKSAQ 52
            |.:.|..|..|:..|   |:..|.|...   .|.||.|.         ||.: .|.||:..:..|
Zfish   412 QNNTDPPPHCAQHPPQEHTHITQKLPGQTDITQKPPGQTDITQKPLGQTDIT-QKPLGRRGRGRQ 475

  Fly    53 DTSTNILDLSKS---SSNSIRSPQALG----GLAIPSTPYASGAYS-----------MLPPDLVA 99
            ..||.  .:.|:   ::..:|:....|    |.|.|:.|.|:...|           ..||   .
Zfish   476 RKSTE--PMGKTGGGAAEELRAGAPHGQDREGCADPAAPLATSEPSSASCRTRRSSKAAPP---V 535

  Fly   100 MANATKFYAQFFPHLLPAYAAAAAAAGLSTPPTSPYQTHQ------HQQHLPNQQKRFFAPYVIN 158
            .||             |....|....|......|..|.||      ...|....||.|
Zfish   536 AAN-------------PRARYACDICGRKFTRRSDVQRHQLTHTGERPFHCGQCQKTF------- 580

  Fly   159 GSVPPPPPLQQQQQPLIR--TKSTACTRPDCPECLDYYQ--RLQTGGYKQTAPLISPAASSVSSS 219
                      |....|.:  .|.....|..|..|...:.  ||.|..:||:.....|...|:...
Zfish   581 ----------QHSWDLSKHCRKQHGEARFSCSVCQSDFTNLRLLTAHHKQSHGGAVPHYCSICGE 635

  Fly   220 T-GS---------IRPVRDLIMSATGGAASTNISLTTVTNLSLNSVQATAVGMMPKMTGGLITTA 274
            | ||         ......|......|.|...:...::...|....|.......||.    .|.:
Zfish   636 TAGSPSALAQHRRSHSAAQLYRCPQCGEAFDTLLQRSLHRQSHRPRQRHQCPQCPKS----FTRS 696

  Fly   275 VGSNSGAIGGIGGYNATSAEEISYKCRICEKVFGCSETLQAHEKTHKSPRYECAD-CGKGFSQLR 338
                    ..:..:..:.:.|..:.|.:|.|.||....|..|:.||...|..|.. |||.|:||.
Zfish   697 --------SDVRRHQLSHSGERPHHCTVCGKSFGLRSGLLKHQATHTGERPHCCTVCGKSFTQLS 753

  Fly   339 NYKYHLSVHRGTKEFAAECPECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVR 403
            ....|..:|.|.:.:.  |.:|||.|...|.|..|.|.|...:.:.||.|||||..:.|...|:.
Zfish   754 ILLRHQRMHTGERPYL--CSQCGKRFLSLGELLKHDKTHAEDRPHTCPQCPKSFKYKRALQEHML 816

  Fly   404 IHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFS 468
            .||||:|:.|..|||.|::...|.:|...|:||:|:.|:.|.::|...:.:.||.|.|:|.:||.
Zfish   817 AHTGVRPYPCRYCGKMFAKPFALNRHHLIHTGERPFSCAHCERTFLTSTELALHERTHTGERPFP 881

  Fly   469 CPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTHAKKCQYRPLDGLTVTSSA 533
            |..||:.|.....|..|...|:|.:|:.|.:  |.:|::.:|.:|:|.:          |.||.
Zfish   882 CTACPRRFRSSSELARHRRTHSGPRPHACRY--CPKAYSSASRLRSHTR----------THTSE- 933

  Fly   534 LPVPGKQQTGP 544
                 |:..||
Zfish   934 -----KRSGGP 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	69/186 (37%)
		C2H2 Zn finger	327..347	CDD:275368	8/20 (40%)
		zf-C2H2	356..377	CDD:278523	9/20 (45%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	11/24 (46%)
		C2H2 Zn finger	385..405	CDD:275368	9/19 (47%)
		zf-H2C2_2	397..422	CDD:290200	12/24 (50%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..449	CDD:290200	8/22 (36%)
		zf-C2H2	439..461	CDD:278523	6/21 (29%)
		C2H2 Zn finger	441..461	CDD:275368	6/19 (32%)
		zf-C2H2	467..489	CDD:278523	7/21 (33%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..515	CDD:275368	5/17 (29%)
si:zfos-932h1.3	XP_021330860.1	TIN2_N	23..199	CDD:240667
		PAT1	<307..>439	CDD:330585	8/26 (31%)
		C2H2 Zn finger	545..565	CDD:275368	5/19 (26%)
		C2H2 Zn finger	573..593	CDD:275368	5/36 (14%)
		C2H2 Zn finger	601..619	CDD:275368	5/17 (29%)
		C2H2 Zn finger	658..678	CDD:275368	2/19 (11%)
		COG5048	<679..861	CDD:227381	62/195 (32%)
		C2H2 Zn finger	686..706	CDD:275368	3/31 (10%)
		C2H2 Zn finger	714..734	CDD:275368	7/19 (37%)
		C2H2 Zn finger	742..762	CDD:275368	7/19 (37%)
		C2H2 Zn finger	770..790	CDD:275368	9/19 (47%)
		C2H2 Zn finger	798..818	CDD:275368	9/19 (47%)
		C2H2 Zn finger	826..846	CDD:275368	7/19 (37%)
		C2H2 Zn finger	854..874	CDD:275368	6/19 (32%)
		zf-H2C2_2	866..891	CDD:316026	11/24 (46%)
		C2H2 Zn finger	882..902	CDD:275368	6/19 (32%)
		zf-H2C2_2	894..919	CDD:316026	8/26 (31%)
		C2H2 Zn finger	910..930	CDD:275368	6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910