DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZSCAN30

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001106205.1	Gene:	ZSCAN30 / 100101467	HGNCID:	33517	Length:	494	Species:	Homo sapiens

Alignment Length:	368	Identity:	116/368 - (31%)
Similarity:	165/368 - (44%)	Gaps:	47/368 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 SPYQTHQHQQHLPNQQKRFFAPYVINGSVPPPPPLQQQQQPLIRTKSTACTRPDCPECLDYYQRL 197
            ||.|..::|.....|:.:.|               |::...::..| ....:.:..||:
Human   162 SPVQPLENQCKTETQESQAF---------------QERDGRMVAGK-VLMAKQEIVECV------ 204

  Fly   198 QTGGYKQTAPLISPAASSVSSSTGSIRPVRDLI------MSATGGAASTNISL--TTVTNLSLNS 254
                  .:|.:|||  ..:...|.|.|...:.:      ....|.||...||.  :...:.||
Human   205 ------ASAAMISP--GKLPGETHSQRIAEEALGGLDNSKKQKGNAAGNKISQLPSQDRHFSL-- 259

  Fly   255 VQATAVGMMPKMTGGLIT-TAVGSNSGAIGGIGGYNATSAEEISYKCRICEKVFGCSETLQAHEK 318
              ||....:|.....|.: .:.||.|.....|...:..:.|:: |:|..|.|.|..|..|..|::
Human   260 --ATFNRRIPTEHSVLESHESEGSFSMNSNDITQQSVDTREKL-YECFDCGKAFCQSSKLIRHQR 321

  Fly   319 THKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPECGKTFNDKGYLSSHLKIHRNRKE 382
            .|...| |.|.:|||.||...:...|..:|.|.|.:  ||.||||.|.....|..|.:||...|.
Human   322 IHTGERPYACKECGKAFSLSSDLVRHQRIHSGEKPY--ECCECGKAFRGSSELIRHRRIHTGEKP 384

  Fly   383 YECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSVCGKS 447
            |||..|.|:|::..|...|.:||||.|.::|..|||.|.|..:|.:|.|.|:|||||:|:.||||
Human   385 YECGECGKAFSRSSALIQHKKIHTGDKSYECIACGKAFGRSSILIEHQRIHTGEKPYECNECGKS 449

  Fly   448 FADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHT 490
            |...|.:|.|.|:|:|.||:.|..|.|.|..:..|..|...||
Human   450 FNQSSALTQHQRIHTGEKPYECSECRKTFRHRSGLMQHQRTHT 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	76/176 (43%)
		C2H2 Zn finger	327..347	CDD:275368	7/19 (37%)
		zf-C2H2	356..377	CDD:278523	9/20 (45%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	11/24 (46%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	12/24 (50%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..449	CDD:290200	14/22 (64%)
		zf-C2H2	439..461	CDD:278523	11/21 (52%)
		C2H2 Zn finger	441..461	CDD:275368	10/19 (53%)
		zf-C2H2	467..489	CDD:278523	6/21 (29%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..515	CDD:275368
ZSCAN30	NP_001106205.1	SCAN	44..154	CDD:128708
		SCAN	44..122	CDD:280241
		COG5048	281..>360	CDD:227381	26/81 (32%)
		zf-C2H2	301..323	CDD:278523	8/21 (38%)
		C2H2 Zn finger	303..323	CDD:275368	7/19 (37%)
		zf-H2C2_2	316..339	CDD:290200	9/22 (41%)
		COG5048	<328..479	CDD:227381	68/152 (45%)
		C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		zf-H2C2_2	343..366	CDD:290200	10/24 (42%)
		C2H2 Zn finger	359..379	CDD:275368	8/19 (42%)
		zf-H2C2_2	371..396	CDD:290200	11/24 (46%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	399..424	CDD:290200	12/24 (50%)
		C2H2 Zn finger	415..435	CDD:275368	9/19 (47%)
		zf-H2C2_2	428..452	CDD:290200	15/23 (65%)
		C2H2 Zn finger	443..463	CDD:275368	10/19 (53%)
		zf-H2C2_2	455..480	CDD:290200	11/24 (46%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910