DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and ANO3

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_001300655.1	Gene:	ANO3 / 63982	HGNCID:	14004	Length:	1042	Species:	Homo sapiens

Alignment Length:	954	Identity:	210/954 - (22%)
Similarity:	328/954 - (34%)	Gaps:	339/954 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GGEDDFTDDNNFESNLRRR--KGKIISCAKETIENASRQLRRKVPYAGHLMTPRR------LWLN 102
            |.:.|:||::...:..|.|  ...:|....|.....|:.....:..:|.|....:      |...
Human   168 GKDKDYTDESEHATYDRSRLINDFVIKDKSEFKTKLSKNDMNYIASSGPLFKDGKKRIDYILVYR 232

  Fly   103 KIPTQCDVVIEFPEDAPDEALRWLLARIRSQPPAGLGLLVQVKAHESTRRNAFYVSAPVNVLFKA 167
            |...|.|....|.::...|.|     .:..:|......::.:|.|           .|.:.|.|.
Human   233 KTNIQYDKRNTFEKNLRAEGL-----MLEKEPAIASPDIMFIKIH-----------IPWDTLCKY 281

  Fly   168 AE--EARLPKRLR-------------------------------------PDLGGALREFTTRES 193
            ||  ..|:|.|.:                                     |||         .||
Human   282 AERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRRIKNWMAQNPMVLDKSAFPDL---------EES 337

  Fly   194 HCFQQ--LRGDV------GSTALFTSQERQWLVLQVLQGLR--AGCSDIEALHGRAAVAEGQSIV 248
            .|:..  .|..:      .....|::..|..:|..:|:..:  .|.|.:..   |..:..|..|.
Human   338 DCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGI---RKLINNGSYIA 399

  Fly   249 ATWQESGLITQVFPLHEPS--SLTQLQTH------------------WVKQIFAPQPLDDIAAYF 293
            |           ||.||.:  |...::||                  |.|.    ||||.|..||
Human   400 A-----------FPPHEGAYKSSQPIKTHGPQNNRHLLYERWARWGMWYKH----QPLDLIRLYF 449

  Fly   294 GVKVALYFAWLGHYTCALGVPAVFGTILY------------------------CILWGKGQTAQD 334
            |.|:.|||||||.||..|...|:.|..::                        |.|..|..:.|.
Human   450 GEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICKATEVFMCPLCDKNCSLQR 514

  Fly   335 M----------------GHVLFSLFNVAWASLYLEAWKRYSVELAFRWGTLSTPPELLEPPRPLY 383
            :                |.|.|::|...||:::||.|||....|.:.|..:....| .|..||.:
Human   515 LNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEE-EETLRPQF 578

  Fly   384 KGPLEE----NNVTGRLEPKEAPAWQRRAFRYLVS----FPIIGCCLCVVFAV----MFLMLRF- 435
            :....:    |.:||:.||.:..:  .:..|.|||    |.:|...:..||.|    :.:|.:|
Human   579 EAKYYKMEIVNPITGKPEPHQPSS--DKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFA 641

  Fly   436 -------QDWWDSKLPEESVLCCLSVIPKVLLAGAITLMDEAYFKLAVWLNDRENYRLQSKYENH 493
                   :.:|  :....:...|::.|       .|.|::.||.|:|..|.:.|..|.:|::||.
Human   642 SFKWNFIKQYW--QFATSAAAVCINFI-------IIMLLNLAYEKIAYLLTNLEYPRTESEWENS 697

  Fly   494 LIAKVALFQFVNSFLSLFYIAFYLR-------------DEEKLKE------------QLAGLLIS 533
            ...|:.||||||...|:|||||:|.             |..:|:|            |:..::..
Human   698 FALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFL 762

  Fly   534 RQIIGNLRESAIPYFLEQWKLAKLSFNMWGALSPTQNVTRSLAEELATAEAELKAESTGTPTKSQ 598
            :||..|..|...|.....|...|:
Human   763 KQIWNNFMELGYPLIQNWWSRHKI----------------------------------------- 786

  Fly   599 QPESSSKRNIGQAEIESSLYKYD---------GTFSDHLEMLVQMGYVVLFSAAFPLAGVCALIN 654
                  ||.|..|.|..  ::.|         |...::|||::|.|:..:|.||||||.:.||:|
Human   787 ------KRGIHDASIPQ--WENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLN 843

  Fly   655 NLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIVNCALIGLSG------------ 707
            |::|||.||:|.....:||...|..:||.|...|..:.:.|||.|..:|.::.
Human   844 NIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKY 908

  Fly   708 -------------------------QVSRLWPGLT---------------------------TAQ 720
                                     .:|.|..|.:                           .|.
Human   909 GPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAA 973

  Fly   721 TIILIVTLEHIMLGLRQALTWLLPELPSWLAAEIARAEHCRREM 764
            .:..|:..||::.|::..:.:|:|::|..|...|.|.::..:||
Human   974 RLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQEM 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	149/626 (24%)
ANO3	NP_001300655.1	Anoct_dimer	218..442	CDD:292796	45/266 (17%)
ANO3	NP_001300655.1	Anoctamin	445..1011	CDD:282414	149/626 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920