DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and ano2b

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_001314787.1	Gene:	ano2b / 566373	ZFINID:	ZDB-GENE-060503-62	Length:	1065	Species:	Danio rerio

Alignment Length:	1105	Identity:	233/1105 - (21%)
Similarity:	384/1105 - (34%)	Gaps:	395/1105 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 STATTTATSTAGELGGGPRDGGEDD--------FTDDNNF-------ESNLRRRKGKIISCAKET 75
            |||.:.::|...:|    ||..|.:        |.|..:|       ..|:.:..|..|..|...
Zfish    22 STALSESSSVCSDL----RDISEIEVMNSISCTFDDSVDFIEESLHHSDNMLQTSGNKIHVANNM 82

  Fly    76 I---ENASRQL-----RRKVPYAGHLMTPRRLWLNKIPTQ------------------------- 107
            :   ::..::|     ||||.|.......:|..:...|:|
Zfish    83 MDMDQDPRKRLYFADGRRKVDYVLVFHYRKRSSIRGSPSQHRLSIISNGSYHLGVEEKDPEGGKE 147

  Fly   108 --CDVVIEF--PEDAPDEALRWLLARIRSQPPAGL---GLLVQVKAHESTRRNAFY-VSAPVNVL 164
              .:||::.  |:.|..|.:     .||.:....|   ||.::.........:||. :.||..||
Zfish   148 EPAEVVVDVGPPDPAEGEKI-----MIREEFEGSLKDAGLEIERDKENKAHGHAFIRLHAPWQVL 207

  Fly   165 FKAAE------------EARLPKRLRPDLGGALREF-----------------TTRESHCFQQ-- 198
            .:.||            |.|..|.|...:....|:.                 |...:|||.:
Zfish   208 SREAEFLKIKVQTKKSYELREEKGLAATMNEVWRKLNQPFQPKVPHQEQENSRTKFLTHCFSRDK 272

  Fly   199 --LRGDVGSTALFTSQERQWLVLQVLQGLRAGCSDIEALHGRAAVAEGQSIVATWQESGLITQVF 261
              |.........|.:..|..:|.::|:  |..|:       |.....|   :.|...:|:....|
Zfish   273 LHLYNIQSKDTFFDNATRSRIVYEILR--RTACT-------RTCQTMG---ITTLIANGVYDSAF 325

  Fly   262 PLHE-----------PSSLTQLQTHWVK--QIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGV 313
            |||:           .:....|...|.:  ..:..||:|.|..|||.|:.|||||||.||..|..
Zfish   326 PLHDGDFHSSGQAEGKNERQLLHDEWARYGAFYKYQPIDLIRKYFGEKIGLYFAWLGVYTQLLIP 390

  Fly   314 PAVFGTILYCILWGKGQT---AQDM-------------------------------GH------- 337
            .:|.|.|::...|...:|   :|:|                               .|
Zfish   391 ASVVGIIVFFYGWATVETNVPSQEMCDETQNFTMCPLCDRVCDYWQLSTACGTARASHLFDNPAT 455

  Fly   338 VLFSLFNVAWASLYLEAWKRYSVELAFRWGTLSTPPELLEPPRPLY------KGPLEENNVTGRL 396
            |.|::|...||:::||.|||..:.|.:.| .|:...|..|.|||.|      |...::.|...:.
Zfish   456 VFFAIFMSLWAAMFLEHWKRRQISLNYSW-DLTGMEEEEEHPRPKYETILLQKRQRKKKNKKNKN 519

  Fly   397 EPK------------------------------EAPAWQRRAFRYLVSFPII----GCCLCVVFA 427
            ||:                              |...|:.|...||::...|    |.....||:
Zfish   520 EPERVVDESGELGKDKWRQRLLSAMAAGNPTGHEKLTWRDRLPGYLINISSILFMFGVTCSAVFS 584

  Fly   428 VMFLMLRFQDWWDSKLPEESVLCCLSVIPKV-------LLAGA-------ITLMDEAYFKLAVWL 478
            |:...:..           |.|..:|..|.|       :.|.|       |.::||.|..:|.||
Zfish   585 VIIYRITI-----------SALMAMSPDPDVKSNVRVTVTATAVIINLVVILILDEIYGMVAAWL 638

  Fly   479 NDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAF-------------YLRDEEKLKE----- 525
            .:.|..:.::.:|..||.|..:.:|:|::..:||:||             |:..:.:::|
Zfish   639 TELEIPKTETNFEERLILKAFVLKFMNAYAPIFYVAFFKGRFAGRPGDYVYVFHDYRMEECAPGG 703

  Fly   526 -------QLAGLLISRQII-GNLRESAIPYFLEQWKLAKLSFNMWGALSPTQNVTRSLAEELATA 582
                   ||:.:::.:|:| .|:.|..||      ||.||              .|:|.:
Zfish   704 CLIELCIQLSIIMLGKQLIQNNVFEIGIP------KLKKL--------------CRTLKD----- 743

  Fly   583 EAELKAESTGTPTKSQQP----ESSSKRNIGQAEIESSLYKYDGTFSDHLEMLVQMGYVVLFSAA 643
                         |.::|    |...:|.  |..::..|..:||...:::||::|.|:|.||.|:
Zfish   744 -------------KDREPKEIVEQPGRRQ--QWHMDYDLEPFDGLTPEYMEMIIQFGFVSLFVAS 793

  Fly   644 FPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIVNCALIGLSG- 707
            ||||.:.||:||::|||.||.|.....:||...|..:||.|.|.||.|...:||:|..:|..:.
Zfish   794 FPLAPLFALLNNVIEIRLDAKKFVTELRRPDAVRTKDIGIWYNILSGLGKFSVIINAFVISFTSD 858

  Fly   708 ----------------------------QVSRLWPGLTTAQTII--------------------- 723
                                        .||...||...:.:.|
Zfish   859 FIPRLVYQYMYSETGTMHGFINHTLSYFNVSNFKPGTMPSTSDITVCRYKDYREPPWSNEPYQFS 923

  Fly   724 ------------LIVTLEHIMLGLRQALTWLLPELPSWLAAEIARAE------------------ 758
                        .::..:::::.:...:.||:|::|..::.::.:.:
Zfish   924 KQYWSVLAARLGFVILFQNLVIIMSMLVAWLIPDMPKNISEQLKKDKTLLVDVFLNEEKEKLQLI 988

  Fly   759 ---------HCRREMQCKGTSPRPTPPTPQSTTSTQPEQEGPGGLQMESGANT------TRDQSM 808
                     :.::|...:..|.:.:.|..||.....|....|......:.|..      ||..||
Zfish   989 QSLFSKDLTNKQQEEHQQQVSDKTSLPLQQSQPGFLPPSSSPASTAPRTRARAASFSQFTRQMSM 1053

Fly 809 808
Zfish 1054 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	150/655 (23%)
ano2b	NP_001314787.1	Anoct_dimer	94..363	CDD:292796	53/285 (19%)
ano2b	NP_001314787.1	Anoctamin	366..968	CDD:282414	150/653 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920