DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and ano10b

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	XP_021326182.1	Gene:	ano10b / 565195	ZFINID:	ZDB-GENE-061013-169	Length:	807	Species:	Danio rerio

Alignment Length:	722	Identity:	214/722 - (29%)
Similarity:	347/722 - (48%)	Gaps:	108/722 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 RKVPYAGH----LMTPRRLWLNKIPTQCD--------VVIEFPEDAPDEALRWLLARIRSQPPAG 137
            :|.|..||    .:|....| :|:...|.        |:|:..|.......:|:::.|.:...||
Zfish   120 QKEPQEGHSTSTKVTGPSSW-SKVSCPCCTSTQIEPLVLIQLAESVQPITKQWIMSVIAAPVKAG 183

  Fly   138 LGLLVQVKAHESTRRNAFYVSAPVNVLFKAAEEARLPKRLRPDLGGALREFT--TRESHCFQQLR 200
             |..:.|...|..:.:...|:||...|.:..||..|.|..:   .|.::.|:  .|::.|
Zfish   184 -GAQLLVHPGEDMKGDMIVVAAPRCTLHRVTEELGLCKTYQ---DGDMKAFSFEDRDNFC----- 239

  Fly   201 GDVGSTALF-TSQERQWLVLQVLQGLRA----GCSDIEALHGRAAVAEGQSIVATWQESGLITQV 260
             ::..|..| |..|||::|...:..::|    ....|.|..|:....|  ||:...:::|||..:
Zfish   240 -NIDDTQQFLTLAERQFIVKHEMDLMKALEDQRIPGIPAPAGKLKARE--SILQKLEKAGLIRSI 301

  Fly   261 FPLHEPSSLTQLQTHWVKQ-IFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGT-ILYC 323
            .|||:...|..|...|..| ....||||.|..|||..:|.||::|..||.:|..||:.|. |.:.
Zfish   302 TPLHDQERLADLGKQWYSQKSLWGQPLDYIHNYFGGTIAYYFSFLDFYTLSLFPPAILGIFITFF 366

  Fly   324 ILWGKGQTA-----------QDMGHVLFS------LFNVAWASLYLEAWKRYSVELAFRWGTLST 371
            :......||           .|..|:..|      :|::.|:::::|.|||.|..|::.|||.:.
Zfish   367 LPSANFSTAIETDSNASSKISDDDHLSVSSYMVQAVFSMLWSTIFMELWKRRSASLSYHWGTFNL 431

  Fly   372 PPELLEPPRPLYKGPLEENNVTGRLEPKEAPAWQRRAFRYLVSFPIIGCCLCVV---FAVMFLML 433
             .|..:.|||.:.|.:..|.|||||||. .|.|:|:....|||.|::|..|.:|   .|..::..
Zfish   432 -AEQFQEPRPGFHGEIGTNPVTGRLEPL-FPDWKRKMRMGLVSVPVVGFFLGLVILGMAGFYICE 494

  Fly   434 RFQDWWDSKLPEES---VLCCLSVIPKVLLAGAITLMDEAYFKLAVWLNDRENYRLQSKYENHLI 495
            |....|.    :||   ....|..:|.:.......::...|..:|:.|.:.||:|.:|.::.|..
Zfish   495 RLVSSWH----KESGSYFTAPLLYLPSIAHIVYTNVLGNVYRNVALKLTEAENHREESSFDYHHT 555

  Fly   496 AKVALFQFVNSFLSLFYIAFYLRDEEKLKEQLAGLLISRQIIGNLRESAIPYFLEQWKLAKLSFN 560
            .||.:|.|.|:|..||:|||:..|...|:::|:.|||..|::|...|..:|:.::::
Zfish   556 TKVLVFTFFNNFAVLFHIAFFKEDMPLLRKRLSSLLIVTQVVGQFTEVVVPFLVDRF-------- 612

  Fly   561 MWGALSPTQNVTRSLAEELATAEAELKAESTGTPTKSQQPESSSKRNIGQAEIESSLYKYDGTFS 625
                              |.:|...||.:         .||      :...:.:.||..:.|.|:
Zfish   613 ------------------LTSANRNLKED---------DPE------VDHLQAQGSLPAFPGLFA 644

  Fly   626 DHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSI 690
            :::|:|||.||:.|||..:||.....|:|||.|||:||:||..:..:||...|||:|.||.|..:
Zfish   645 EYIELLVQFGYLSLFSCVYPLTAPLLLLNNLTEIRTDAYKLCKLFNKPFSAPVANLGVWQLAFEV 709

  Fly   691 LSLAAVIVNCALIGLSGQVSRLW---PGLTTAQTIILIVTLEHIMLGLRQALTWLLPELPSWLAA 752
            ||..:||.||.|:.||.:|.. |   .||:::|.|::.|.:||::|.::..|.:::|:.|.||..
Zfish   710 LSFISVISNCWLLLLSPRVKE-WTQEAGLSSSQVIVIAVIVEHVLLIVKMILAFIIPDEPDWLQV 773

  Fly   753 EIARAEH 759
            :..:.|:
Zfish   774 KREQIEY 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	155/495 (31%)
ano10b	XP_021326182.1	Anoctamin	331..777	CDD:309610	155/493 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0001419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100943
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720