Protein Alignment CG15270 and ano8b

DIOPT Version :9

• Sequence 1: NP_609738.1
• Gene: CG15270 / 34886
• FlyBaseID: FBgn0028879
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: XP_021335376.1
• Gene: ano8b / 562782
• ZFINID: ZDB-GENE-121024-1
• Length: 1110
• Species: Danio rerio
• Alignment Length: 1302
• Identity: 397/1302 - (30%)
• Similarity: 548/1302 - (42%)
• Gaps: 391/1302 - (30%)

  Fly    23 VPDSTATTTATSTAGELGGGPRDGGEDDFTDDNNFESNLRRRKGKIISCAKETIENASRQLRRKV 87
            :|| ||...|.|:|..:...  ..||         .|.||.|       |:...|.|.:|.....
Zfish     2 MPD-TAAAAAASSASNISSS--SDGE---------SSRLRHR-------AQGDAERAEQQQHTAA 47

  Fly    88 P-----------------YAGHLMTPRRLWLNKIPTQ-CDVVIEFPEDAPDEALRWLLARIRSQP 134
            |                 .||..:...:.|:..:||: |||::.||:...|..|.|||..||...
Zfish    48 PQTTSAGVLDKLFGKRLLQAGRHIMSHKSWMKTVPTENCDVLMTFPDTTDDHTLLWLLNHIRLGI 112

  Fly   135 PAGLGLLVQVKAHESTRRNAFYVSAPVNVLFKAAEEARLPKRLRPDLGGALREFTTRESHCFQQL 199
            |.   |::|::.|:.||..||:|:|....|.:.|||..|.|.::|:.||..|.|:..|.:.::.:
Zfish   113 PE---LIIQIRHHKHTRMYAFFVTATYENLLRGAEEMGLQKAVKPEFGGGSRSFSCEEDYIYENI 174

  Fly   200 RGDVGSTALFTSQERQWLVLQVLQGLRAGCSDIEALHGRAAVAEGQSIVATWQESGLITQVFPLH 264
            ..::   ..|||||||.::...|..|||  ...|||| .....|||.|:...:..|:|.||||||
Zfish   175 ESEL---CFFTSQERQSIIKYWLDNLRA--KHGEALH-NIHFLEGQPIIPELRARGVIQQVFPLH 233

  Fly   265 EPSSLTQLQTHWVKQIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGTILYCILWGKG 329
            |...|.||...||:.:...||||||..|||||:|:||||||.||.::..|||.|.:|: :|....
Zfish   234 EQRILGQLMKSWVQAVCEKQPLDDICDYFGVKIAMYFAWLGFYTTSMLYPAVIGFVLW-MLTESD 297

  Fly   330 QTAQDMGHVLFSLFNVAWASLYLEAWKRYSVELAFRWGTLSTPPELLEPPRPLYKGPLEENNVTG 394
            ||::|:..|:|:||||.||:|:||.|||...|||::||||:||.|.||.|||.::|....:.|||
Zfish   298 QTSRDICCVVFALFNVVWATLFLERWKRRGAELAYKWGTLNTPAESLEEPRPQFRGVKRCSPVTG 362

  Fly   395 RLEPKEAPAWQRRAFRYLVSFPIIGCCLCVVFAVMFLMLRFQDW--WDSKLPEESVLCCLSVIPK 457
             .|....|.|:||.||:|||||:...|||.||..|.:....|::  ...:||..:     ..|||
Zfish   363 -CEEFYYPPWRRRVFRWLVSFPVCILCLCFVFLAMLVCFELQEFVMGIKELPRVA-----RFIPK 421

  Fly   458 VLLAGAITLMDEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAFYLRDEEK 522
            ::||..:|..||.|.|:|.||||.|||||||.||.:||.|:.|||||||:||||||.|||:|.|:
Zfish   422 IMLAITVTACDEVYRKIACWLNDMENYRLQSAYEKNLIIKMVLFQFVNSYLSLFYIGFYLKDMER 486

  Fly   523 LKEQLAGLLISRQIIGNLRESAIPYFLEQWKLAKLSFN-MWGAL--------------------S 566
            |||.||.|||.||.:.|::|...||..|:.:|.:|:.. :|..|                    .
Zfish   487 LKEMLATLLIIRQFVQNMKEVLQPYLAERHRLGELTLRAVWELLVSALLKYGRLAAGRAQVSPSD 551

  Fly   567 PT-----------------------------------------------QNVTRSL--------- 575
            ||                                               :|.:.||
Zfish   552 PTVLGPGLRGPQMGEEGHQDRRERKCLNGGCGVPDEDMEEEHGERHSEEENESESLIDCGLKLRK 616

  Fly   576 -----------------------------------------------------------AEELAT 581
                                                                       ||.|.|
Zfish   617 VSFIEKVERKSASCVSPVDDSFLEEGSPTMVERGMDPASVFEMCDDEDENGAPEMKELAAEPLPT 681

  Fly   582 -------------------AEAELKAESTGTPTKSQQPESSSKRNIGQAEIESSLYKYDGTFSDH 627
                               |:::.|.:|...|     ||......:.|||:|..:..|..||.|:
Zfish   682 GVENSSSVKLRKRGRSLERADSKTKRDSWMDP-----PEEQETNTLTQAEVEGCMQTYQDTFQDY 741

  Fly   628 LEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILS 692
            .||.||.|||||||:|||||.:||||||::|||||||||....|||||.|||:||.||..:..:.
Zfish   742 QEMFVQFGYVVLFSSAFPLAAMCALINNIIEIRSDAFKLCTSLQRPFGLRVASIGQWQTVMEAMG 806

  Fly   693 LAAVIVNCALIGLSGQVSRLWPGLTTAQTIILIVTLEHIMLGLRQALTWLLPELPSWLAAEIARA 757
            |.|:||||.|||..||:.||:|.|:....||.||.|||..:.|:..:...:|::|||:..|:|:.
Zfish   807 LIAIIVNCYLIGQCGQLQRLFPWLSPEMAIISIVILEHFAVLLKYIIHVAIPDIPSWVGEEMAKL 871

  Fly   758 EHCRREMQCKGTSPRPTPPTPQSTTSTQPEQEGPGGLQMESGANTTRDQSMESQVAEDILLYGQE 822
            |..|:|...|  ..|......|.....:.|:|             .|.:..|.|...|
Zfish   872 EFQRKEAFKK--HERQAQQHFQQQQRRKREEE-------------ERQRQAEYQARRD------- 914

  Fly   823 FAGYGHNIEADVNIYENRDSSPDSPPSQTSTILIRPLHESTPPHGGASLTSLHQDGNGGACQSWV 887
                            ..|...|:..|.         |     |...|.:...:.|.||......
Zfish   915 ----------------RDDGRSDASGSD---------H-----HHEKSQSGKARSGGGGGSSGGE 949

  Fly   888 KKSQMFIPEIPPYLGYSVRNLTTFAGNSRKMQQHQKLQSGASASTLALNSAAYAARMQSMHIQEI 952
            |      |:.|          ::..||:..|:                             :::|
Zfish   950 K------PKRP----------SSLLGNNNVMK-----------------------------LKQI 969

  Fly   953 PPFRKKSTDSADHTGSSASSSPQRTTMRQLSAQREPQQQTIPEIPPYKTRKISAESAMHLNMSDK 1017
            .|.:.|.:       |..:.|||..|..:            |::|.:.:.|.
Zfish   970 IPLQNKFS-------SGTARSPQSPTGNE------------PKLPGFLSFKF------------- 1002

  Fly  1018 LHIKLHAPEWMSRLKVNDNANLHRSIDCISKELGNSADTADILKPAPSWCNVAMRSGAPGSNLAT 1082
                |.:||                   ..||...::.:|.:   ||.......||.:|  |.:.
Zfish  1003 ----LKSPE-------------------NKKEAAMASASASV---APPVQEKVERSQSP--NKSF 1039

  Fly  1083 PPA-------SQHQQQIVASSSSSSGGGGSVFSP-------SG-----PGPAGASGVGISNSQSR 1128
            .|.       |:....:..:..|..|.||.:...       :|     |.|.|.:|...|:|.:.
Zfish  1040 NPGKLFNFGKSEGGACVNGAQLSKLGDGGQMQDKPPTKSDLNGVPDEIPSPCGENGENGSSSDAD 1104

  Fly  1129 PS 1130
            ||
Zfish  1105 PS 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	237/625 (38%)
ano8b	XP_021335376.1	Anoctamin	258..870	CDD:309610	236/623 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592282
Domainoid	1	1.000	441	1.000	Domainoid score	I521
eggNOG	1	0.900	-	-		E1_KOG2513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	569	1.000	Inparanoid score	I1030
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0001419
OrthoInspector	1	1.000	-	-		otm24572
orthoMCL	1	0.900	-	-		OOG6_100943
Panther	1	1.100	-	-	LDO	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X3826
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790