DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and ano3

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	XP_021326430.1	Gene:	ano3 / 553392	ZFINID:	ZDB-GENE-111031-3	Length:	1026	Species:	Danio rerio

Alignment Length:	1018	Identity:	221/1018 - (21%)
Similarity:	357/1018 - (35%)	Gaps:	354/1018 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VPFSEQQQS---SEDVPDSTATTTATSTAGELGGGPRDGGEDDFTDD---NNFESNLRRRKGKII 69
            ||.|...:|   |..|..|....|..:|         |.|:|.:|::   ..||.    :..:.:
Zfish    74 VPLSPGPKSYTHSSSVSASCTHITPPAT---------DTGQDVYTEERETGGFEP----KTDETL 125

  Fly    70 SCAKETIENASRQLRRKVPYAGHLMTPRRLWLNKIPTQCDVVIEFPEDAPDEALRWLLAR-IRSQ 133
            ...::.:.....:.|.......:|.||..|.......:.|.::.:.:.:|....|....| :|::
Zfish   126 LVQQKPVSRGKLEARTDSVKGKNLETPSGLMFRDGKKRIDYILVYKKSSPQVEKRCTFERNLRAE 190

  Fly   134 PPAGLGLLVQVKAHESTRRNAFYVS--APVNVLFKAAEE-------------------------- 170
                 ||::: |....|..:..:|.  ||.:.|.|.||:
Zfish   191 -----GLMLE-KEPSLTNSDIMFVKIHAPWDTLCKYAEQMNIRMPFRKKCYFTDWKKKAMGSRFQ 249

  Fly   171 --------------ARLPKRLRPDL-----------GGALREFTTRESHCFQQLRGDVGSTALFT 210
                          .:|.|...|||           ...:..||......|            |:
Zfish   250 LRFRQLKSWLPRNPMKLDKEALPDLVETDCYTAPFCRARMHHFTINNRETF------------FS 302

  Fly   211 SQERQWLVLQVLQGLR-----------AGCSDIEALHGR-AAVAEGQSIVATWQ------ESGLI 257
            :..|..:|..|||..:           ..|.::...:|: ..:..||| .::|:      .:...
Zfish   303 NSTRSRIVHHVLQRTKYEDGKSKMAPPLCCLNLLYYYGQHERLLIGQS-GSSWEGINRLLGNSTY 366

  Fly   258 TQVFPLHEP--SSLTQLQTH------------------WVKQIFAPQPLDDIAAYFGVKVALYFA 302
            ...||.||.  .|...::||                  |.|.    ||||.|..|||.|:.||||
Zfish   367 EAAFPPHEGCYKSRHPIKTHGAQNHRHLLYERWARWGIWYKY----QPLDLIRRYFGEKIGLYFA 427

  Fly   303 WLGHYTCALGVPAVFGTILYCILWG-----KGQTAQDM--------------------------- 335
            |||.||..|...|:.|  |:..|:|     ..|.::::
Zfish   428 WLGWYTGMLIPAALVG--LFVFLYGLFTMDSSQVSKEICEANTTVMCPMCEGNCSSWTLSDSCVY 490

  Fly   336 ----------GHVLFSLFNVAWASLYLEAWKRYSVELAFRWGTLSTPPELLEP--------PRPL 382
                      |.|.|::|...||:::||.|||...||.:.|..:....|..:|        .||.
Zfish   491 AKVTHLFDNGGTVFFAIFMAIWATVFLEFWKRRRAELTYDWDLIDWEEEECKPCVMVCSEELRPQ 555

  Fly   383 YKGPLEE----NNVTGRLEPKEAPAWQRRAFRYLVS----FPIIGCCLCVVFAVMFLML------ 433
            ::.....    |.::|:.||.: |...:.: |.:||    |.:|...|..||||:...|
Zfish   556 FEAKYSRKERVNPISGKPEPFQ-PLTDKLS-RLMVSVSGIFFMISLVLTAVFAVVVFRLIAMEKF 618

  Fly   434 -RFQDW------WDSKLPEESVLCCLSVIPKVLLAGAITLMDEAYFKLAVWLNDRENYRLQSKYE 491
             .|| |      |........|  |::.:       .|..::..|.|:|..|.:.|:.|.:|::|
Zfish   619 VSFQ-WEFVKKNWQFATSGTGV--CINFM-------IIMSLNVVYEKVAYLLTNLEHPRTESEWE 673

  Fly   492 NHLIAKVALFQFVNSFLSLFYIAFYL-----------------RDEE--------KLKEQLAGLL 531
            |....|:.||||||...|.|||||:|                 |.||        .|..|:..::
Zfish   674 NSFALKMFLFQFVNLNSSTFYIAFFLGRFAGRPGDYNKLFNRWRMEECHPSGCLIDLCLQMGVIM 738

  Fly   532 ISRQIIGNLRESAIPYFLEQWKLAKLSFNMWGALSPTQNVTRSLAEELATAEAELKAESTGTPTK 596
            :.:||..|..|...|.....|...|:                                      |
Zfish   739 VLKQIWNNFMELGYPLLQNWWSRRKM--------------------------------------K 765

  Fly   597 SQQPESSSKRNIGQAEIESSLYKYD--GTFSDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEI 659
            ....:|:||..:.|.:.:.:|...:  |...::|||::|.|:..:|.||||||.:.||:||::||
Zfish   766 RAGEQSNSKEELPQWDRDWNLQPMNAHGLVDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEI 830

  Fly   660 RSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIVNCALIGLS------------------ 706
            |.||:|.....:||...|..:||.|...|..:.:.|||.|..:|.::
Zfish   831 RLDAYKFVTQWRRPMPARATDIGIWHGVLEGIGVVAVITNAFVIAITSDYIPRFVYAIKYGPCVD 895

  Fly   707 ----------------------GQVS----------------------------RLWPGLTTAQT 721
                                  |::.                            :.|..|  |..
Zfish   896 KGYRHEKCLRGYLNNSLSVFDMGELRNGSYENQYCRYRDYRAPPWSPEPYEFTLQFWHVL--AAR 958

  Fly   722 IILIVTLEHIMLGLRQALTWLLPELPSWLAAEIARAEHCRREM 764
            :..|:..||::.|::..:..::|::|..|...:.|.::..:||
Zfish   959 LAFIIVFEHLVFGIKTFIAHMIPDMPKDLCDRMRREKYLMQEM 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	150/634 (24%)
ano3	XP_021326430.1	Anoct_dimer	163..411	CDD:318420	46/270 (17%)
ano3	XP_021326430.1	Anoctamin	414..994	CDD:309610	149/633 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920