DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and ANO10

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_001333393.1	Gene:	ANO10 / 55129	HGNCID:	25519	Length:	699	Species:	Homo sapiens

Alignment Length:	749	Identity:	240/749 - (32%)
Similarity:	364/749 - (48%)	Gaps:	132/749 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 VVIEFPEDAPDEALRWLLARIRSQPPAG------LGLLVQVKAHESTRRNAFYVSAPVNVLFKAA 168
            ||||..:|..:|...||..||.::...|      ..||.:.:......:|.:.|.|....:...|
Human    19 VVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYEQETLENQNLYLVGASKIRMLLGA 83

  Fly   169 EEARLPKRLRPDLGGALREFTTRESHCFQQLRG-DVGSTALFTSQERQWLVLQVLQGLRAGCSDI 232
            |...|.|....:   .:|.||.|..   |..:| |..:....|..|.|:::...|:.|||  .|.
Human    84 EAVGLVKECNDN---TMRAFTYRTR---QNFKGFDDNNDDFLTMAECQFIIKHELENLRA--KDE 140

  Fly   233 EALHG--RAAVAEGQSIVATWQESGLITQVFPLHEPSSLTQLQTHWVKQIFA--PQPLDDIAAYF 293
            :.:.|  :|.:..|:|::.....||::.||||||:..:|.:|:..|..: ||  .||:|.|..||
Human   141 KMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALKKLEDTWYTR-FALKYQPIDSIRGYF 204

  Fly   294 GVKVALYFAWLGHYTCALGVPAVFGTILYCILWGKGQTAQDMG-HVLFSLFNVAWASLYLEAWKR 357
            |..:||||.:|.::|.||...||.|...|..:|      :|.. :|:|:.||:.|:::.||.|||
Human   205 GETIALYFGFLEYFTFALIPMAVIGLPYYLFVW------EDYDKYVIFASFNLIWSTVILELWKR 263

  Fly   358 YSVELAFRWGTLSTPPELLEPPRPLYKGPLEENNVTGRLEPKEAPAWQRRAFRYLVSFPIIGCCL 422
            ....:.:|||||....: .|.|||.:.|.|..|::||:.||. .|:::|:...||||.|.:  ||
Human   264 GCANMTYRWGTLLMKRK-FEEPRPGFHGVLGINSITGKEEPL-YPSYKRQLRIYLVSLPFV--CL 324

  Fly   423 CVVFAVMFLMLRF-QDWWDSKLPEESVLCCLSV---IPKVLLAGAITLMDEAYFKLAVWLNDREN 483
            |:.|::..:|:.| .:.|...|.|.|.....||   :|.::.|..|.:|:..|...|.:|...||
Human   325 CLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVPSIIYAIVIEIMNRLYRYAAEFLTSWEN 389

  Fly   484 YRLQSKYENHLIAKVALFQFVNSFLSLFYIAFYLRDEEKLKEQLAGLLISRQIIGNLRESAIPYF 548
            :||:|.|:||||.||.:|.|:|.|.|||||||.|:|.:.|::.||.|||:.||:..:.||.:||:
Human   390 HRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKDMKLLRQSLATLLITSQILNQIMESFLPYW 454

  Fly   549 LEQWKLAKLSFNMWGALSPTQNVTRSLAEELATAEAELKAESTGTPTKSQQPESSSKRNIGQAEI 613
            |:                      |.....:......|||:...|..:             |..:
Human   455 LQ----------------------RKHGVRVKRKVQALKADIDATLYE-------------QVIL 484

  Fly   614 ESSLYKYDGTFSDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRV 678
            |..:..|.|||.|:||:.:|.|||.|||..:|||...|::||..|:.|||.|:..|.:|||.:..
Human   485 EKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPS 549

  Fly   679 ANIGTW---------------------------------------QNALSILSLAAVIVNCALIG 704
            ||||.|                                       |.|...:|:.:|:.||||||
Human   550 ANIGVWQIIFCLDTGVKRGLNCKVMRNLLGEMEMSCVLFVVVVVSQLAFETMSVISVVTNCALIG 614

  Fly   705 LSGQVSRLWPGLTTAQTIILIVTLEHIMLGLRQALTWLLPELPSWLAAEIARAE----HCRREMQ 765
            :|.||:.::|. :.|..|:::|.:||.:|.|:..|.:.:|:.|..:..::||.|    ...::.|
Human   615 MSPQVNAVFPE-SKADLILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQ 678

  Fly   766 CKGTSPRPTPPTPQSTTSTQPEQEGPGGLQMESG 799
            .|              ..|:..:|.|    ||||
Human   679 MK--------------LVTENLKEEP----MESG 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	175/512 (34%)
ANO10	NP_001333393.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0001419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100943
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720