DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and ANO7

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	XP_011509565.1	Gene:	ANO7 / 50636	HGNCID:	31677	Length:	940	Species:	Homo sapiens

Alignment Length:	858	Identity:	202/858 - (23%)
Similarity:	313/858 - (36%)	Gaps:	309/858 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 DVVIEFP-EDAPDEALRWLLARIRSQPPAGLGLLVQVKAHESTRRNAFYVSAPVNVLFKAAEEA- 171
            |:.::.| ::.|::|..|           ..|||.             ::..| |||.:...:.
Human   184 DLRLKLPLQELPNQASNW-----------SAGLLA-------------WLGIP-NVLLEVVPDVP 223

  Fly   172 -----------RLPKRLRPDLGGALREFTTRESHCFQQLRGDVGSTALFTSQERQWLVLQVLQGL 225
                       :||:.|                       |.......|||.:|..::.::|...
Human   224 PEYYSCRFRVNKLPRFL-----------------------GSDNQDTFFTSTKRHQILFEILAKT 265

  Fly   226 RAGCSDIEALHGRAAVAEGQSIVATWQESGLITQVFPLHE---------PSS--LTQLQT---HW 276
            ..|......|.....:||           |:::..||||:         |.:  |.|.|.   ||
Human   266 PYGHEKKNLLGIHQLLAE-----------GVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHW 319

  Fly   277 VK--QIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGTILY----------------- 322
            .:  :....||||.:..|||.||||||||||.||..|...||.||:::
Human   320 ARWGKWNKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELC 384

  Fly   323 -----------------------CILWGKGQTAQDMGHVLFSLFNVAWASLYLEAWKRYSVELAF 364
                                   |.|...|:.....|.|.||||...||.|.||.|||.|..||:
Human   385 GSKDSFEMCPLCLDCPFWLLSSACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAY 449

  Fly   365 RWGTLSTPPELLEPPRPLY--KGPL-EENNVTGRLEPKEAPAWQRRAFRYLVSFPIIGCCLCVVF 426
            || ..|...:..|.|||.:  ..|: ..|.:||..||....  :.||.|.|....:|...:.||
Human   450 RW-DCSDYEDTEERPRPQFAASAPMTAPNPITGEDEPYFPE--RSRARRMLAGSVVIVVMVAVV- 510

  Fly   427 AVMFLMLRFQDWWDSKLPEESVLCCLSVI-------------PKVLLAG---------------- 462
                                 |:|.:|:|             ...|||.
Human   511 ---------------------VMCLVSIILYRAIMAIVVSRSGNTLLAAWASRIASLTGSVVNLV 554

  Fly   463 AITLMDEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAFY----------- 516
            .|.::.:.|..||..|...|.:|.|:|:|:....||.:|||||.:.|..||||:
Human   555 FILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLKVFIFQFVNFYSSPVYIAFFKGRFVGYPGNY 619

  Fly   517 -----LRDEE--------KLKEQLAGLLISRQIIGNLRESAIPYFLEQWKLAKLSFNMWGALSPT 568
                 :|:||        :|.::|..:::.:|:|.|::|..||.....|:..:|.
Human   620 HTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLR---------- 674

  Fly   569 QNVTRSLAEELATAEAELKAESTGTPTKSQQPESSSKRNIGQAEIESSLYKYDGTFSDHLEMLVQ 633
                                      :|.::..:|:..:.|..|.:..|...:|.|.::|||::|
Human   675 --------------------------SKKRKAGASAGASQGPWEDDYELVPCEGLFDEYLEMVLQ 713

  Fly   634 MGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIV 698
            .|:|.:|.||.|||.:.||:||.:|||.||.|....::||..:|..:||.|.:.|:.|:..|||.
Human   714 FGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVIS 778

  Fly   699 NCALIGLS-------------------------------------------------GQVSRLWP 714
            |..|:..|                                                 |..|:.:.
Human   779 NAFLLAFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNRTCRYRAFRDDDGHYSQTYW 843

  Fly   715 GLTTAQTIILIVTLEHIMLGLRQALTWLLPELPSWLAAEIARAEHCRREMQCK-----GTSPRPT 774
            .| .|..:..::..||::..:.:.|..|:|::|..:..::.|..:..::...:     ||:
Human   844 NL-LAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAENEVLFGTN---- 903

  Fly   775 PPTPQSTTSTQPE 787
                 .|...|||
Human   904 -----GTKDEQPE 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	156/613 (25%)
ANO7	XP_011509565.1	Anoct_dimer	106..331	CDD:292796	37/205 (18%)
ANO7	XP_011509565.1	Anoctamin	334..885	CDD:282414	155/612 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950