DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and subdued

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_001189248.1	Gene:	subdued / 42340	FlyBaseID:	FBgn0038721	Length:	1099	Species:	Drosophila melanogaster

Alignment Length:	837	Identity:	209/837 - (24%)
Similarity:	335/837 - (40%)	Gaps:	231/837 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 FPEDAPDEALRWLLA-RIRSQPPAGL-----------GLLVQVKAHESTRRNAFY---VSAPVNV 163
            |.||.. .::.::|| ||.:..|..|           .|:.|....||::::..:   :.||:.|
  Fly   186 FFEDCV-RSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVESSQKDQIWFVKIHAPLEV 249

  Fly   164 LFKAAE--EARLP--------------KRLR----------PDLGGALREFTTRE-----SHCFQ 197
            |.:.||  :.|:|              .|||          |.:....|  :|:.     .|.||
  Fly   250 LRRYAEILKLRMPMKESLCNLRISERSNRLRNAAHYLTNKIPGMSVVNR--STKSVFSSLKHVFQ 312

  Fly   198 -QLRGDVGSTALFTSQERQWLVL-----QVLQGLRAGCSDIEALHGRAA--VAEGQSIVATWQE- 253
             .||.......:|..:..::..:     :.|..:|..|....|:..|..  :.:.|...|..|.
  Fly   313 FFLRNIYVDEEIFPKRAHRFTAIYSRDKEYLFDIRQDCFFTTAVRSRIVEFILDRQRFPAKNQHD 377

  Fly   254 ----------SGLITQVFPLHEPSSLTQ-------LQTHW--VKQIFAPQPLDDIAAYFGVKVAL 299
                      .|:.:..:|||: ..:|:       |..||  |.:.:..||||||..|||||:.|
  Fly   378 MAFGIERLIAEGVYSAAYPLHD-GEITETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGL 441

  Fly   300 YFAWLGHYTCALGVPAVFGTILY--------------------------------CILWGKGQTA 332
            ||||||:||..|.:.::.|.|.:                                |..|...:|.
  Fly   442 YFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDWCNFWDLKETC 506

  Fly   333 ---------QDMGHVLFSLFNVAWASLYLEAWKRYSVELAFRWGTLSTPPELL------EPPRPL 382
                     .:...|.|::|...||:|:||.|||||.|:..||       :|.      |.|||.
  Fly   507 NYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRW-------DLTGFDVHEEHPRPQ 564

  Fly   383 YKGPLEE------NNVTGRLEPKEAPAWQRRAFRYLVSFPIIGCCLCVVFAVMFLMLRFQDWWDS 441
            |...||.      :.||...|| ..|.|:.:....:.||.::...:.:.|..:..::.::
  Fly   565 YLARLEHIPPTRVDYVTNIKEP-TVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYR----- 623

  Fly   442 KLPEESVLCCLSV-------IPKVLLAGA---------ITLMDEAYFKLAVWLNDRENYRLQSKY 490
                .|:|..|.|       ...::||.|         :.:::..|..||.:|.:.|.:|.|:::
  Fly   624 ----MSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQF 684

  Fly   491 ENHLIAKVALFQFVNSFLSLFYIAFY----------------LRDEE--------KLKEQLAGLL 531
            ::.|..|:.|.||||.:.|:|||||:                .|.||        :|..|||.::
  Fly   685 DDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFDYRQEECSSGGCLTELCIQLAIIM 749

  Fly   532 ISRQIIGNLRESAIPYFLEQWKLAKLSFNMWGALSPTQNVTRSLAEELATAEAELKAESTGTPTK 596
            :.:|....:.|..:|.|   |:                        ::...:..|......||..
  Fly   750 VGKQAFNTILEVYLPMF---WR------------------------KVLAIQVGLSRLFNNTPNP 787

  Fly   597 SQQPESSSKRNIGQAEIESSLYKYDGTFSDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRS 661
            .:..:....|:....:     :...|.|.::|||::|.|:|.:|.||||||...||:||::|:|.
  Fly   788 DKAKDERWMRDFKLLD-----WGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRL 847

  Fly   662 DAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIVNCALIGLSGQVSRLWPGLTTAQTIILIV 726
            ||.||...|:||..|||.:||.|...|..:...:||.|..:|..:   |.:.|.|.....:....
  Fly   848 DAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFT---SDMIPRLVYRHYVNKQG 909

  Fly   727 TLE-HIMLGLRQALTWLLPELPSWLAAEIARAEHCRREMQCKGTSPRPTPPTPQSTT 782
            ||: ::...|.:......|.|.| ||.:::....||.      |..|..|.:|:..|
  Fly   910 TLDGYLNFTLSEFKVIDSPTLYS-LAGDLSNITTCRY------TDFRLPPSSPEKYT 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	147/562 (26%)
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:292796	51/245 (21%)
subdued	NP_001189248.1	Anoctamin	431..1007	CDD:282414	154/588 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437684
Domainoid	1	1.000	52	1.000	Domainoid score	I2829
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.980