Protein Alignment wwk and Ano7

DIOPT Version :10

• Sequence 1: NP_609738.1
• Gene: wwk / 34886
• FlyBaseID: FBgn0028879
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: NP_996914.1
• Gene: Ano7 / 404545
• MGIID: 3052714
• Length: 859
• Species: Mus musculus
• Alignment Length: 940
• Identity: 220/940 - (23%)
• Similarity: 343/940 - (36%)
• Gaps: 289/940 - (30%)

  Fly     1 MHGNEEVRDGVPFSEQQQSSEDVPDSTATTTATSTAGELGGGPRDGGED-----DFT----DDNN 56
            :.|.....|.|...:..........|..:|...|.||:....|...|..     ||.    :|..
Mouse     2 LRGQAREEDSVVLIDMASPEAGNGCSYGSTAQASEAGKQQVAPSRVGSSAKPPIDFVLVWEEDLR 66

  Fly    57 FESNLRRRKGKIISCAKET-IEN---ASRQLR----RKVPYAGHLMTPRRLWLNKIPTQCDVVIE 113
            .:.|..:.|.......:|| :||   |..::.    :....|.|.:..|..|........|:.::
Mouse    67 NQENPTKDKTDTHEVWRETFLENLCLAGLKIDQHDVQDEAAAVHYILLRAPWAVLCYYAEDLRLK 131

  Fly   114 FP-EDAPDEALRW-------------LLARIRSQPPAGLGLLVQVKAHESTRRNAFYVSAPVNVL 164
            .| ::.|::|..|             ||..:...||.                   |.|..
Mouse   132 LPLQELPNQASNWSATLLEWLGIPNILLEHVPDTPPE-------------------YYSCQ---- 173

  Fly   165 FKAAEEARLPKRLRPDLGGALREFTTRESHCFQQLRGDVGSTALFTSQERQWLVLQVLQGLRAGC 229
            |||::                          .|...|.......|||.:|..::.::|.....|
Mouse   174 FKASK--------------------------LQWFLGSDNQDTFFTSTKRHQILFEILAKTPYG- 211

  Fly   230 SDIEALHGRAAVAEGQSIVATWQESGLITQVFPLHE------PSS-----LTQLQT---HWVK-- 278
                  |.:..:.....::|    .|:.:..||||:      |.|     |.|.|.   ||.:
Mouse   212 ------HEKKGLFGIDQLLA----EGVFSAAFPLHDGPFSAVPESSQVLGLIQRQVLFQHWARWG 266

  Fly   279 QIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGTILY--------------------- 322
            :....||||.:..|||.||||||||||.||..|...||.||:::
Mouse   267 KWNKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLPAAVVGTVVFLVGCFLVFSDIPTQELCHSSD 331

  Fly   323 -------------------CILWGKGQTAQDMGHVLFSLFNVAWASLYLEAWKRYSVELAFRWGT 368
                               |.|...|:.....|.|.||||...||.|.||.|||.:..||:|| .
Mouse   332 SFDMCPLCSDCSFWLLSSACTLAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKNATLAYRW-D 395

  Fly   369 LSTPPELLEPPRPLY--KGPLEE-NNVTGRLEPKEAPAWQRRAFRYLVS--------FPIIGCCL 422
            .|...::.|.|||.:  ..|:.. |.:||..||....  :.|..|.|..        ..:|.|.:
Mouse   396 CSDYEDIEERPRPQFAATAPMTALNPITGEDEPYFPE--KNRVRRMLAGSVVLLMMVAVVIMCLV 458

  Fly   423 CVVF--AVMFLML-----RFQDWWDSKLPEESVLCCLSVIPKVLLAGAITLMDEAYFKLAVWLND 480
            .|:.  |||.:::     .|...|.|::        .|:...|:....|.::.:.|..||..|..
Mouse   459 SVILYRAVMAIIVSRSDNAFLSAWASRI--------ASLTGSVVNLVFILILSKVYVLLAQVLTR 515

  Fly   481 RENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAFY----------------LRDEE-------- 521
            .|.:|.|:::|:....||.:|||||.:.|..||||:                :|:||
Mouse   516 WEMHRTQTEFEDAFTLKVFIFQFVNFYASPVYIAFFKGRFVGYPGNYHTLFGIRNEECPAGGCLS 580

  Fly   522 KLKEQLAGLLISRQIIGNLRESAIPYFLEQWKLAKLSFNMWGALSPTQNVTRSLAEELATAEAEL 586
            :|.::|..:::.:|||.|::|..:|.....|                |..:|.
Mouse   581 ELAQELLVIMVGKQIINNVQEVLVPKLKGCW----------------QKFSRG------------ 617

  Fly   587 KAESTGTPTKSQQPESSSKRNIGQAEIESSLYKYDGTFSDHLEMLVQMGYVVLFSAAFPLAGVCA 651
            |...|||             :....|.:..|...:|.|.::|||::|.|:|.:|.||.|||.:.|
Mouse   618 KKAGTGT-------------HPAPWEADYELLPCEGLFHEYLEMVLQFGFVTIFVAACPLAPLFA 669

  Fly   652 LINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIVNCALIGLSGQ-------- 708
            |:||.:|||.||.|....::||..:|..:||.|.:.|:.|:..|||.|..|:..|..
Mouse   670 LLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILTGLTHLAVISNAFLLAFSSDFLPRVYYS 734

  Fly   709 --------------VSRLWPGLTTAQT--------------------------IILIVTLEHIML 733
                          ::|..|..|:|..                          :..::..||::.
Mouse   735 WTHAPDLHGFLNFTLARAPPTFTSAHNRTCRYRAFRDDDGHYSPTYWTLLAIRLAFVIVFEHVVF 799

  Fly   734 GLRQALTWLLPELPSWLAAEIARAEHCRRE 763
            .:.:.|..|:|::|..:..::.|..:..::
Mouse   800 SIGRVLDLLVPDIPESVEIKVKREYYLAKQ 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wwk	NP_609738.1	Anoctamin	289..756	CDD:461349	155/596 (26%)
Ano7	NP_996914.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..50		7/24 (29%)
		Anoct_dimer	52..274	CDD:465044	51/281 (18%)
		Anoctamin	277..823	CDD:461349	155/597 (26%)