DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and Ano8

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	XP_017168360.1	Gene:	Ano8 / 382014	MGIID:	2687327	Length:	1212	Species:	Mus musculus

Alignment Length:	974	Identity:	309/974 - (31%)
Similarity:	426/974 - (43%)	Gaps:	319/974 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 RKVPYAGHLMTPRRLWLNKIPTQ-CDVVIEFPEDAPDEALRWLLARIRSQPPAGLGLLVQVKAHE 148
            :::..||..:...:.|:..:||: |||::.||:...|..|.|||..||...|.   |:|||:.|.
Mouse    41 KRLLQAGRYLVSHKAWMKTVPTEDCDVLMTFPDTTDDHTLLWLLNHIRVGIPE---LIVQVRHHR 102

  Fly   149 STRRNAFYVSAPVNVLFKAAEEARLPKRLRPDLGGALREFTTRESHCFQQLRGDVGSTALFTSQE 213
            .||..||:|:|....|.:.|:|..|.|.::.:.||..|.|:..|...::.:..::   ..|||||
Mouse   103 HTRAYAFFVTATYESLLRGADELGLRKAVKAEFGGGTRSFSCEEDFIYENVESEL---RFFTSQE 164

  Fly   214 RQWLVLQVLQGLRAGCSDIEALHGRAAVAEGQSIVATWQESGLITQVFPLHEPSSLTQLQTHWVK 278
            ||.::...||.|||  ...|||| .....|.|.|:......|:|.||||:||...|.:|...||:
Mouse   165 RQSIIRFWLQNLRA--KQGEALH-NVRFLEDQPIIPELAARGIIQQVFPVHEQRILNRLMKSWVQ 226

  Fly   279 QIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGTILYCILWGKGQTAQDMGHVLFSLF 343
            .:...||||||..|||||:|:||||||.||.|:..|||||::||... ...||::|:..|:|:||
Mouse   227 AVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFT-EADQTSRDVSCVVFALF 290

  Fly   344 NVAWASLYLEAWKRYSVELAFRWGTLSTPPELLEPPRPLYKGPLEENNVTGRLEPKEAPAWQRRA 408
            ||.|::|:||.|||...|||::||||.:|.|.:|.|||.::|....:.:| |.|....|.|:|..
Mouse   291 NVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGIRRISPIT-RAEEFYYPPWKRLL 354

  Fly   409 FRYLVSFPIIGCCLCVVFAVMFLMLRFQDWWDSKLPEESVLCCLSV---------IPKVLLAGAI 464
            |:.|||.|:...||..||.:|....:.|:            ..|||         :|||:||..:
Mouse   355 FQLLVSLPLCLACLICVFILMLGCFQLQE------------LVLSVKGLPRLVRFLPKVMLALLV 407

  Fly   465 TLMDEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAFYLRDEEKLKE---- 525
            ::..|.|.||||||||.|||||:|.||.|||.||.|||||||:||||||.|||:|.::|||
Mouse   408 SVSAEGYKKLAVWLNDMENYRLESTYERHLIIKVVLFQFVNSYLSLFYIGFYLKDMDRLKEVRAC 472

  Fly   526 ----------------------------------------------------------------- 525

Mouse   473 APSQGQHPGPLGMDPCKGSRALQPLPPVLHPSLLFVRLSMCPFSACRSPLPSVRPPVRLVPPQLL 537

  Fly   526 ------------------------------------------QLAGLLISRQIIGNLRESAIPYF 548
                                                      .||.|||:||::.|:||...|:.
Mouse   538 LLLSLTQSLERQLQAVLVPLAALRFRLLLLSLRGLLLVARAKMLATLLITRQLLQNVREVLQPHL 602

  Fly   549 L---------------------------------------------------------------- 549
            .
Mouse   603 YRRLGSGELGLRTILELARALLGLLNPLRPDPRRHLEAQADEGGAGSRRCLGGGCGAPEEENEEE 667

  Fly   550 -------------------------------------EQW------------KLAKLSFNMWGA- 564
                                                 |::            :|.|:||...||
Mouse   668 EEAAVERRPAGEGGEVPEGPRGGKEEDEEEDDDEDEDEEYEGEEGSLLDCGLRLKKVSFAERGAG 732

  Fly   565 --------------LSPTQNVTRSLAEELAT-AEAELKAES-TGTPTKSQQ-------------- 599
                          .|||. |.:.|...:.| ||.:.:.|. .|:|....|
Mouse   733 RRRPGPSPDGLLEEGSPTM-VEKGLEPGVFTLAEEDDEPEGPPGSPGPEPQTVLLRRARGEGRDQ 796

  Fly   600 ------------------------------PESSSKRNIGQAEIESSLYKYDGTFSDHLEMLVQM 634
                                          ||......:.|||:||.:.||:.||.|:.||.||.
Mouse   797 GPDGDRDTETGSGDAAGRQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQF 861

  Fly   635 GYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIVN 699
            |||||||:|||||.:|||:|||:|||||||||....|||||:||.:||.||..:..:.:.|::||
Mouse   862 GYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVN 926

  Fly   700 CALIGLSGQVSRLWPGLTTAQTIILIVTLEHIMLGLRQALTWLLPELPSWLAAEIARAEHCRRE 763
            |.|||..||:.||:|.|:....|:.:|.|||:.|.::..:...:|::|.|:|.|:|:.|:.|||
Mouse   927 CYLIGQCGQLQRLFPWLSPEAAIVSVVVLEHLALLVKYLIHVAIPDIPGWVAEEMAKLEYQRRE 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	230/762 (30%)
Ano8	XP_017168360.1	Anoctamin	237..>606	CDD:367984	132/382 (35%)
		Anoctamin	<814..983	CDD:367984	78/168 (46%)
		PRK12323	<1031..>1210	CDD:237057
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847073
Domainoid	1	1.000	417	1.000	Domainoid score	I655
eggNOG	1	0.900	-	-		E1_KOG2513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	578	1.000	Inparanoid score	I1029
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0001419
OrthoInspector	1	1.000	-	-		oto93592
orthoMCL	1	0.900	-	-		OOG6_100943
Panther	1	1.100	-	-	LDO	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X3826
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790