DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and ANO9

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_001012302.2	Gene:	ANO9 / 338440	HGNCID:	20679	Length:	782	Species:	Homo sapiens

Alignment Length:	735	Identity:	169/735 - (22%)
Similarity:	268/735 - (36%)	Gaps:	236/735 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 LQVLQGLRAGCSDIEALHGRAAVAEGQSIVATWQE---SGLITQVFPLHEPSSLTQLQTHWV--K 278
            :.|...||....:...::.:.:..|      |:::   .|:....||||:...  :|:..|.  :
Human   112 IPVTTSLRIRIVNFVVMNNKTSAGE------TFEDLMKDGVFEARFPLHKGEG--RLKKTWARWR 168

  Fly   279 QIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPA------VF-------------------G 318
            .:|..||:|:|..|||.||||||.|||.||..| |||      ||                   .
Human   169 HMFREQPVDEIRNYFGEKVALYFVWLGWYTYML-VPAALTGLLVFLSGFSLFEASQISKEICEAH 232

  Fly   319 TILYCILWGKGQTAQDM----------------GHVLFSLFNVAWASLYLEAWKRYSVELAFRWG 367
            .||.|.|....:..|.:                |.|:|::|...||:::||.|||....:...|
Human   233 DILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHW- 296

  Fly   368 TLSTPPELLEPPRPLYKGPLEENNVTGRLEPKEAPAWQRRAFRY-------LVSFPIIGCCLCVV 425
                         .||....|:..:.  |:....|.::.|.:::       ::...::..||.:.
Human   297 -------------DLYVWDEEQEEMA--LQLINCPDYKLRPYQHSYLRSTVILVLTLLMICLMIG 346

  Fly   426 FA---VMFLMLRFQDWWDSKLP--EESVLCCLSVIPKVLLAGAITLMDEAYFKLAVWLNDRENYR 485
            .|   |::.:|....:..|.:|  ||.|...:.|...::....|.:|.:....:|:.|.|.|..|
Human   347 MAHVLVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPR 411

  Fly   486 LQSKYENHLIAKVALFQFVNSFLSLFYIAFYLRDEE-------------KLKE------------ 525
            ..|:.|:....:....||...|.||.||||.|....             ||:|
Human   412 TFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFV 476

  Fly   526 QLAGLLISRQIIGNLRESAIPYFLEQWKLAKLSFNMWGALSPTQNVTRSLAEELATAEAELKAES 590
            |:|.::..:|.:.|..|..:|     |...|               .|||.          .:||
Human   477 QMAIIMGLKQTLSNCVEYLVP-----WVTHK---------------CRSLR----------ASES 511

  Fly   591 TGTPTKSQQPESSS-KRNIGQAEIESSLYKYDGTFS---DHLEMLVQMGYVVLFSAAFPLAGVCA 651
            ...|   :.||... :||.        |.....|||   :.:||::|.|:..:|.||||||.:.|
Human   512 GHLP---RDPELRDWRRNY--------LLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLA 565

  Fly   652 LINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIVNCALIG------------ 704
            |.:||:|||.||.|:..:.:|...::..:||||...|..:.:.|||.|..:|.
Human   566 LFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYK 630

  Fly   705 ----------------LSGQVS-----------------------------------------RL 712
                            |.|.|:                                         :.
Human   631 YRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQF 695

  Fly   713 WPGLTTAQTIILIVTLEHIMLGLRQALTWLLPELPSWLAAEIARAEHCR-REMQCKGTS------ 770
            |  ...|..:..::..||:.|.::....|.:|::|..:..::...::.| ||....|..
Human   696 W--FLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGVG 758

  Fly   771 -----PRPTPPTPQSTTSTQ 785
                 |.|..|||.|..|.:
Human   759 AGSRPPMPAHPTPASIFSAR 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	142/619 (23%)
ANO9	NP_001012302.2	Anoct_dimer	<115..176	CDD:292796	13/68 (19%)
		Anoctamin	179..735	CDD:282414	142/615 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	756..782		7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920