DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and CG10353

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster

Alignment Length:	932	Identity:	228/932 - (24%)
Similarity:	352/932 - (37%)	Gaps:	290/932 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GELGGGPRDGGEDDF------TDDN--NFESNLRRRKGKIISCAKETIENASRQLRRKVPYAGHL 93
            |..|.|.:.||:|:.      |..|  |.:..|.....:..|......::..|.:...:.|.|..
  Fly   136 GVTGDGGQGGGDDEVSRRLLRTSSNISNKDKKLPITYSQWKSRTYRRFDDGKRSVDFVLAYNGET 200

  Fly    94 MTPRRLWLNKIPTQCDVVIEFPEDAPDEALRWLLARIRSQPPAGLGLLVQVKAHESTRRNAFYVS 158
            .      |.:...:|::   |..:...|.|                   |::.::..|.:...:.
  Fly   201 Q------LEEHRRKCEI---FEANLQREGL-------------------QLEHNKVQRVHFIKIH 237

  Fly   159 APVNVLFKAAEEARLPKRLRPDLG------GALREFTTRESHCFQQLRGDVGS-----TALFTSQ 212
            ||..||::.||..::...|:|..|      .:..||.|    ||.::...:.|     ||||..:
  Fly   238 APAEVLYRYAEILKIKVPLKPIPGQDQIFAESAHEFKT----CFSRMCKSLFSSVQLNTALFPER 298

  Fly   213 E--------RQWLVLQVLQG---LRAGC--SDIEALHGRAAVAEGQSI-----VATWQESGLITQ 259
            |        |.:|.|...:.   |.|..  |.|..:..|....||:..     :....:.|:.|.
  Fly   299 EPRIHLEFSRNYLELYDTEHPNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTC 363

  Fly   260 VFPLHEPSSLTQLQTHWV-----KQIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGT 319
            .:.||:.....:|...|.     |.:   ||||.|..|||.||||||||||.||..|...:|||.
  Fly   364 AYTLHDKDDRDRLLKEWANISKWKNL---QPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGV 425

  Fly   320 ILYC---ILWGKGQTAQDMGH-------------------------------------VLFSLFN 344
            :.:.   |.|.....::|:..                                     |:|:...
  Fly   426 LCFLYGFITWNSDPISRDICDDNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSM 490

  Fly   345 VAWASLYLEAWKRYSVELAFRWGTLSTPPELLEPPRPLY----------KGPLEENNVTGR---L 396
            ..||.:|||.|||||..|..||| |:.....:|.|||.|          .|...|.:.||:   |
  Fly   491 AIWAVVYLEFWKRYSAGLVHRWG-LTGFTHHVEHPRPQYLARISRTKKLAGKAYEQDHTGKRTIL 554

  Fly   397 EPKEAPAWQRRAFRYLVSFP-----IIGCCLCVVFAVMFLMLRFQDWWDSKL--PEESVLCCLSV 454
            :| :.|.|   :|::|.:|.     ::..|:.|:.....::.|........:  .|.|:...:.:
  Fly   555 DP-DVPFW---SFKFLPNFTSYSIMVLFICISVIAIAGIIIYRMAQRASHSILGSENSMTFKVMI 615

  Fly   455 IPKVLLAG-----AITLMDEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIA 514
            :|  :.||     .|:|:|..|..|||.|.:.|..|.|::|:..|..|..:|||||.:.||||||
  Fly   616 LP--MTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIA 678

  Fly   515 FY----------------LRDEE--------KLKEQLAGLLISRQIIGNLRESAIPYFLEQWKLA 555
            |.                .|.||        :|..||..::..:|.:..:.|..|||.:..:|
  Fly   679 FLKGKFVGYPAKYNRVLGFRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFK-- 741

  Fly   556 KLSF-NMWGALSPTQNVTRSLAEELATAEAELKAESTGTPTKSQQPES-------SSKRNIGQAE 612
            :||: :.|                                .||.|.:.       :...|:..||
  Fly   742 ELSYRHGW--------------------------------YKSHQDQRLVPYNQFTEDYNLLPAE 774

  Fly   613 IESSLYKYDGTFSDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQR 677
             .:|||      .::|||:||.|::.|||.|||||.:.||:||::|:|.||.|:....:||.|.|
  Fly   775 -NNSLY------VEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMR 832

  Fly   678 VANIGTWQNALSILSLAAVIVNCALIGLSG---------------------------------QV 709
            ..:||.|.:.:::::..||..:..:|..|.                                 ||
  Fly   833 ARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMGDPELNNYLNFTLAVFNTKDFQV 897

  Fly   710 SRL---------------------------------WPGLTTAQTIILIVTLEHIMLGLRQALTW 741
            ..|                                 |..||  ..:..||..::|:..|:..|.|
  Fly   898 QPLLGGSQHVNETVCRYTEFRNSPEDPHPYKRPMIYWKILT--GRLAFIVIYQNIITMLQGILRW 960

  Fly   742 LLPELPSWLAAEIARAEHCRRE 763
            .:|::...|...|.|.....||
  Fly   961 AVPDVSGRLLKRIKRENFLLRE 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	164/631 (26%)
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	48/243 (20%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	164/631 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I2829
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.050