DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and Ano4

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	XP_006513818.1	Gene:	Ano4 / 320091	MGIID:	2443344	Length:	1154	Species:	Mus musculus

Alignment Length:	999	Identity:	216/999 - (21%)
Similarity:	350/999 - (35%)	Gaps:	352/999 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RDGVPFSE----QQQSSEDV----------------------PDSTATTTATSTAGELGGGPRDG 46
            :..|.|||    .|:.::||                      |.:..:|:..::..|.||
Mouse   238 KSDVDFSEILNAIQEMAKDVNILFDELEAVNSPCKDDDSLLHPGNLTSTSEDTSRLEAGG----- 297

  Fly    47 GEDDFTDDNNFESNLRRRKGK-----IISCAKETIENASRQL-RRKVPYAGHLMTPRRLWLNKIP 105
               :...:.|..:.|..|.||     |:...|...:...|:: .|.:...|..|......:|.
Mouse   298 ---ETVRERNKSNGLYFRDGKCRIDYILVYRKSNPQTEKREVFERNIRAEGLQMEKESSLINS-- 357

  Fly   106 TQCDVVIEFPEDAPDEALRWLLARIRSQPPAGLGLLVQVKAHESTRRNAFYVSAPVNVLFKAAEE 170
               |::. ....||.|.|.....::..:.|              .||..:|:......:.:..::
Mouse   358 ---DIIF-VKLHAPWEVLGRYAEQMNVRMP--------------FRRKIYYLPRRYKFMSRIDKQ 404

  Fly   171 ------------ARLPKRLRPDLGGALREFTTRESHCF------QQLRGDV--GSTALFTSQERQ 215
                        .||.|...|||         .|:.|:      |::...:  .....|.:..|.
Mouse   405 ISRFRRWLPKKPMRLDKETLPDL---------EENDCYTAPFSQQRIHHFIIHNKDTFFNNATRS 460

  Fly   216 WLVLQVLQGLRAGCSDIEALHGRAAVAEGQSIVATWQ--ESGLITQVFPLHEPS--SLTQLQTH- 275
            .:|..:||              |....||::.:...:  .:|.....|||||.|  |...::||
Mouse   461 RIVHHILQ--------------RIKYEEGKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIKTHG 511

  Fly   276 -----------------WVKQIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGTILY- 322
                             |.|.    ||||.:..|||.|:.|||||||.||..|...|..|..::
Mouse   512 AVNHRHLLYECWASWGVWYKY----QPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFL 572

  Fly   323 ---------------------------------------CI------LWGKGQTAQDMGHVLFSL 342
                                                   |:      |:..|.|      |.|::
Mouse   573 YGVTTLDHCQVSKEVCQATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGAT------VFFAV 631

  Fly   343 FNVAWASLYLEAWKRYSVELAFRWGTLSTPPELLEPPRPLYKGPLEE----NNVTGRLEPKEAPA 403
            |...||:::||.|||....:|:.|..:....| .|..||.::....:    |.::|:.||.:  |
Mouse   632 FMAVWATVFLEFWKRRRAVIAYDWDLIDWEEE-EEEIRPQFEAKYSKKERMNPISGKPEPYQ--A 693

  Fly   404 WQRRAFRYLVSFPIIGCCLCVVFAVMFLMLRFQ----------DWW----DSKLPEESVLCCLSV 454
            :..:..|.:||...|...:|||.|.:|.::.::          .|.    :|::.......|::.
Mouse   694 FTDKCSRLIVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWALIRNNSQVATTGTAVCINF 758

  Fly   455 IPKVLLAGAITLMDEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAF---- 515
            .       .|.|::..|.|:|:.|.:.|..|.:|::||....|:.||||||...|.|||||
Mouse   759 C-------IIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGR 816

  Fly   516 -------YLR--DEEKLKE------------QLAGLLISRQIIGNLRESAIPYFLEQWKLAKLSF 559
                   |||  :..:|:|            |:..:::.:|...|..|...|.....|...|:
Mouse   817 FTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKV-- 879

  Fly   560 NMWGALSPTQNVTRSLAEELATAEAELKAESTGTPTKSQQPESSSKRNIGQAEIESSLYKYDGTF 624
                                        .:..||..|...|:.....|:      ..:..| |.|
Mouse   880 ----------------------------RQEHGTERKINFPQWEKDYNL------QPMNAY-GLF 909

  Fly   625 SDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALS 689
            .::|||::|.|:..:|.||||||.:.||:||::|||.||:|.....:||...|..:||.|...|.
Mouse   910 DEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILE 974

  Fly   690 ILSLAAVIVN----------------------CALIGLSGQ------------VSRL-------- 712
            .:.:.:||.|                      ||..|.:||            |.|:
Mouse   975 GIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSE 1039

  Fly   713 -------------------------------------WPGLTTAQTIILIVTLEHIMLGLRQALT 740
                                                 |..|  |..:..|:..||::..::..::
Mouse  1040 PESDGSEFSGTPLKYCRYRDYRDPPHSLAPYGYTLQFWHVL--AARLAFIIVFEHLVFCIKHLIS 1102

  Fly   741 WLLPELPSWLAAEIARAEHCRREM 764
            :|:|:||..|...:.|.::..:||
Mouse  1103 YLIPDLPKDLRDRMRREKYLIQEM 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	148/636 (23%)
Ano4	XP_006513818.1	Anoct_dimer	310..535	CDD:374413	49/271 (18%)
Ano4	XP_006513818.1	Anoctamin	538..1119	CDD:367984	147/635 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950