DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and Ano6

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	XP_008763957.1	Gene:	Ano6 / 315272	RGDID:	1304765	Length:	932	Species:	Rattus norvegicus

Alignment Length:	998	Identity:	214/998 - (21%)
Similarity:	342/998 - (34%)	Gaps:	379/998 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DVPDSTA-------------------TTTATSTAGELGGGPRD---------GGEDD---FTDDN 55
            |||||..                   .|...||.|.| ....|         .|:.|   |||..
  Rat    26 DVPDSRRPFLAPHTPLPSGLVLENFDQTIVCSTFGSL-ESQEDFRTPEFEEFNGKPDSLFFTDGQ 89

  Fly    56 N-------FESNLRRRKGKIISCAKETIENASRQLRRKVPYAGHLMTPRRLWLNKIPTQCDVVIE 113
            .       :|...::...|     |.|.|   :|.|::..|..:|::.            .:.:|
  Rat    90 RRIDFVLVYEDESKKENNK-----KGTNE---KQKRKRQAYESNLISH------------GLQLE 134

  Fly   114 FPEDAPDEALRWLLARIRSQPPAGLGLLVQVKAHESTRRNAFYVSAPVNVLFKAAEEARLPKRLR 178
            ......|:.                  ||.||.|           ||..||...||...:...|:
  Rat   135 ATRSVSDDK------------------LVFVKVH-----------APWEVLCTYAEIMHIKLPLK 170

  Fly   179 PD-------------LGGALR----------EFTTRESHCFQQLRGD----VGSTALFTSQERQW 216
            |:             ....||          ||.|..   |::.|.:    :...:.|....|..
  Rat   171 PNDLKTRSTFDTFNWFTKVLRVNESVIKPEQEFFTAP---FEKSRMNDFYILDRDSFFNPATRSR 232

  Fly   217 LVLQVLQGLRAGCSDIEALHGRAAVAEGQSIVATWQESGLITQVFPLHE------------PSSL 269
            :|..:|..::....:.....|          :.....||:....||||:            ||..
  Rat   233 IVYFILSRVKYQVMNNVNKFG----------INRLVSSGIYKAAFPLHDCKFNYKSEDPNCPSER 287

  Fly   270 TQLQTHWV--KQIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGT--ILY-------- 322
            ..|...|.  :.|:..||||.|..|:|.|:.:||||||:||..|.:.||.|.  .||
  Rat   288 YLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNC 352

  Fly   323 ------------------------CILWGKGQTAQ---------DMGHVLFSLFNVAWASLYLEA 354
                                    |..|....|.:         ..|.::|::|...|.:|:||.
  Rat   353 TWSKEVCDPDIGGQILMCPQCDRLCPFWRLNITCESSKKLCIFDSFGTLIFAVFMGVWVTLFLEF 417

  Fly   355 WKRYSVELAFRWGTLSTPPELLEPPRPLYKGPLEE---NNVTGRLEPKEAPAWQRRAFRYLVSFP 416
            |||...||.:.|.|:....|  |.|||.|:.....   |.:|...|              .:.|.
  Rat   418 WKRRQAELEYEWDTVELQQE--EQPRPEYEAQCNHVVINEITQEEE--------------RIPFT 466

  Fly   417 IIGCCLCVVF---AVMFLML------------RFQDW--WDSKLPEE-----------SVLCCLS 453
            ..|.|:.:..   ||.|.:|            |...:  :.:.||:.           :.....|
  Rat   467 TCGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSTTLPKNPNGTDPIQKYLTPQMATS 531

  Fly   454 VIPKVLLAGAITLMDEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAFY-- 516
            :...::....|.:::..|.|:|:.:.:.|..|.|:.|||.|..|:.||||||.:.|.|||||:
  Rat   532 ITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKG 596

  Fly   517 ---------------LRDEE--------KLKEQLAGLLISRQIIGNLRESAIPYFLEQWKLAKLS 558
                           .|:||        :|..||..::..:.|..|::|..:|:.:
  Rat   597 KFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWVM--------- 652

  Fly   559 FNMWGALSPTQNVTRSLAEELATAEAELKAESTGTPTKSQ----QPESSSKRNIGQAEIESSLYK 619
             |:.|.....     |.:|::             ||...|    ||       :|:.
  Rat   653 -NLIGRYKRV-----SGSEKI-------------TPRWEQDYHLQP-------MGRL-------- 683

  Fly   620 YDGTFSDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTW 684
              |.|.::|||::|.|:|.||.|:||||.:.||:||::|||.||:||....:|...::..:||.|
  Rat   684 --GLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIGAW 746

  Fly   685 QNALSILSLAAVIVNCALIGL-SGQVSRL---W-------------------------------- 713
            |..:..:::.||:.|..:|.. |..:.||   |
  Rat   747 QPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINNTLSVFNITDFK 811

  Fly   714 -------------------------PG------------LTTAQTIILIVTLEHIMLGLRQALTW 741
                                     ||            ...|..:..|:.:||::..::..:::
  Rat   812 NTDKENPYIGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISY 876

  Fly   742 LLPELPSWLAAEIARAEHCRREM 764
            .:|::.....::|.|.::..:::
  Rat   877 AIPDVSKITKSKIKREKYLTQKL 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	147/644 (23%)
Ano6	XP_008763957.1	Anoct_dimer	84..306	CDD:292796	51/283 (18%)
Ano6	XP_008763957.1	Anoctamin	309..893	CDD:282414	147/644 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920