DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and Ano5

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	XP_006229328.1	Gene:	Ano5 / 308637	RGDID:	1564265	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	879	Identity:	195/879 - (22%)
Similarity:	327/879 - (37%)	Gaps:	272/879 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 LRRKVPYAGHLMTPRRLWLNKIPTQCDVVIEFPEDAPDEALRWLLARIRSQP------PAGLGLL 141
            |||::.:.....:...::......|.|.|:.:.||...:.   .|...|.|.      ..||.|.
  Rat   394 LRRRLMFQRSEQSKDSVFFRDGIRQIDFVLSYVEDVKKDG---ELKAERRQTFEQNLRKTGLELE 455

  Fly   142 VQVKAHESTRRNAFY-VSAPVNVLFKAAE--EARLPKRL----RPDLG------GALR------- 186
            ::.|.:....:..|. :.||..||...||  ..::|.:|    ||...      |.::
  Rat   456 IEDKMNSEDGKTYFVKIHAPWEVLVTYAEVLGIKMPIKLSDIPRPKYSPLSYMLGPVKLPLGVKY 520

  Fly   187 ----EFTTRESHCFQQLRGDVGSTALFTSQERQWLVLQVLQGLRAGCSDIEALHGRAAVAEGQSI 247
                .||.:.|...|:|.........|.|..|..:|..:|.....|..:     |:..:.
  Rat   521 PKPEYFTAQFSRHRQELFLIEDEATFFPSSTRNRIVYYILSRCPFGEEE-----GKKKIG----- 575

  Fly   248 VATWQESGLITQVFPLHE-----PSSLTQLQTHWV--------KQIFAPQPLDDIAAYFGVKVAL 299
            :.....:......:|||:     ||..:::...:|        ...:..||.|.|..|:|.|:.:
  Rat   576 IERLLNTNTYLSAYPLHDGQYWRPSKTSRINERYVLCKNWARFSYFYKEQPFDLIRNYYGEKIGI 640

  Fly   300 YFAWLGHYTCALGVPAVFGTILYCILWG-----KGQTAQDM------------------------ 335
            ||.:||:||..|...|:.|  |.|.::|     ..||:.::
  Rat   641 YFVFLGYYTEMLLFAALVG--LACFIYGLLSMESNQTSIEICDPNIGGQMIMCPLCDEVCDYWRL 703

  Fly   336 ---------GH-------VLFSLFNVAWASLYLEAWKRYSVELAFRWGTLSTPPELLE-PPRPLY 383
                     .|       |.|::|...|.:|:||.||:....|.:.|..:....|..: ..||.:
  Rat   704 NTTCLHSKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRPEF 768

  Fly   384 KGPLEE---NNVTGRLEPKEAPAWQRRAFRYLVSFPII--GCCLCVVFAVMFLMLR------FQD 437
            :...:.   |.||..:|| ..|...|..: |.||...:  |..|.:...|..::.|      |..
  Rat   769 EAMCKHKKMNPVTQEMEP-HMPLCHRIPW-YFVSGTTVTFGMALLLSSMVSIIVYRLSVFAIFAS 831

  Fly   438 WWDSKLPEESV-------------LCCLSVIPKVLLAGAITLMDEAYFKLAVWLNDRENYRLQSK 489
            :.:|:...:||             ..||:.:       .|.:::..|.|::.|:...|..|...:
  Rat   832 FMESEATLQSVKRFFTPQLATALSASCLNCL-------VILILNFFYEKISAWITKMEIPRTHQE 889

  Fly   490 YENHLIAKVALFQFVNSFLSLFYIAFY-----------------LRDEE--------KLKEQLAG 529
            ||:.|..|:.||||||.:.|.||:||:                 .|.||        :|..||..
  Rat   890 YESSLTLKMFLFQFVNYYSSCFYVAFFKGKFVGYPGRYTYMFNLWRSEECGPPGCLIELTTQLTI 954

  Fly   530 LLISRQIIGNLRESAIPYFLEQWKLAKLSFNMWGALSPTQNVTRSLAEELATAEAELKAESTGTP 594
            ::|.:||.||:.|:..|          |.||.|     .:..||:.:|:|.:.
  Rat   955 IMIGKQIFGNIHEACQP----------LIFNWW-----RRRRTRTHSEKLYSR------------ 992

  Fly   595 TKSQQPESSSKRNIGQAEIESSLYKYDGTFSDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEI 659
                          .:.:.:..:|.:.|.|.::||.::|.|:|.||.|:||||.:.||:||:|.|
  Rat   993 --------------WEQDHDLQVYGHRGLFYEYLETVMQFGFVTLFVASFPLAPLFALMNNIMGI 1043

  Fly   660 RSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIVNCALIG-------------------- 704
            |.||:||...::||...:..:||.||:.|..:::.:|..|..::.
  Rat  1044 RVDAWKLTTQYRRPVAAKAHSIGVWQDILYGMAILSVATNAFIVSFTSDIIPRLVYFYAYSKNST 1108

  Fly   705 --LSGQVS---------------------------------------------RLWPGLTTAQTI 722
              |||.::                                             :.|..|....|.
  Rat  1109 EPLSGYINNSLSVFLIADFPNHTVPMEKKDFVTCRYRDYRYPPDHKGKYGHNMQFWHVLAAKMTF 1173

  Fly   723 ILIVTLEHIMLGLRQALTWLLPELPSWLAAEIAR 756
            |::  :|||:...:..|.|::|::|..:|.:|.|
  Rat  1174 IIV--MEHIVFLFKFLLAWMIPDVPKDVAEKIKR 1205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	147/630 (23%)
Ano5	XP_006229328.1	MIP-T3	30..>371	CDD:287245
		Anoct_dimer	411..626	CDD:292796	42/227 (19%)
		Anoctamin	630..1207	CDD:282414	147/630 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920