Protein Alignment wwk and Ano8

DIOPT Version :10

• Sequence 1: NP_609738.1
• Gene: wwk / 34886
• FlyBaseID: FBgn0028879
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: XP_038950925.1
• Gene: Ano8 / 306340
• RGDID: 1563946
• Length: 1141
• Species: Rattus norvegicus
• Alignment Length: 906
• Identity: 313/906 - (34%)
• Similarity: 431/906 - (47%)
• Gaps: 253/906 - (27%)

  Fly    85 RKVPYAGHLMTPRRLWLNKIPTQ-CDVVIEFPEDAPDEALRWLLARIRSQPPAGLGLLVQVKAHE 148
            :::..||..:...:.|:..:||: |||::.||:...|..|.|||..||...|.   |:|||:.|.
  Rat    41 KRLLQAGRYLVSHKAWMKTVPTEDCDVLMTFPDTTDDHTLLWLLNHIRVGIPE---LIVQVRHHR 102

  Fly   149 STRRNAFYVSAPVNVLFKAAEEARLPKRLRPDLGGALREFTTRESHCFQQLRGDVGSTALFTSQE 213
            .||..||:|:|....|.:.|:|..|.|.::.:.||..|.|:..|...::.:..::   ..|||||
  Rat   103 HTRAYAFFVTATYESLLRGADELGLRKAVKAEFGGGTRSFSCEEDFIYENVENEL---RFFTSQE 164

  Fly   214 RQWLVLQVLQGLRAGCSDIEALHGRAAVAEGQSIVATWQESGLITQVFPLHEPSSLTQLQTHWVK 278
            ||.::...||.|||  ...|||| .....|.|.|:......|:|.||||:||...|.:|...||:
  Rat   165 RQSIIRFWLQNLRA--KQGEALH-NVRFLEDQPIIPELAARGIIQQVFPVHEQRILNRLMKSWVQ 226

  Fly   279 QIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGTILYCILWGKGQTAQDMGHVLFSLF 343
            .:...||||||..|||||:|:||||||.||.|:..|||||::||... ...||::|:..|:|:||
  Rat   227 AVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFT-EADQTSRDVSCVVFALF 290

  Fly   344 NVAWASLYLEAWKRYSVELAFRWGTLSTPPELLEPPRPLYKGPLEENNVTGRLEPKEAPAWQRRA 408
            ||.|::|:||.|||...|||::||||.:|.|.:|.|||.::|....:.:| |.|....|.|:|..
  Rat   291 NVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGIRRISPIT-RAEEFYYPPWKRLL 354

  Fly   409 FRYLVSFPIIGCCLCVVFAVMFLMLRFQDWWDSKLPEESVLCCLSV---------IPKVLLAGAI 464
            |:.|||.|:...||..||.:|....:.|:            ..|||         :|||:||..:
  Rat   355 FQLLVSLPLCLACLVCVFVLMLGCFQLQE------------LVLSVKGLPRLVRFLPKVILALLV 407

  Fly   465 TLMDEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAFYLRDEEKLKE---- 525
            ::..|.|.||||||||.|||||:|.||.|||.||.|||||||:||||||.|||:|.::|||
  Rat   408 SVSAEGYKKLAVWLNDMENYRLESTYERHLIIKVVLFQFVNSYLSLFYIGFYLKDMDRLKELLLL 472

  Fly   526 ----------------------------------------QLAGLLISRQIIGNLRESAIPYFL- 549
                                                    .||.|||:||::.|:||...|:..
  Rat   473 LSLTQSLERQLRAALVPLAALRFRLLLLSLRGLLLVARAKMLATLLITRQLLQNVREVLQPHLYR 537

  Fly   550 ----------------------------------------------------------------- 549
                                                                             
  Rat   538 RLGSGELGLRTILELARALLGLLNPLRPDPRRHLEAQADEGGAGSRRCLGGGCGAPEEEEEVAVE 602

  Fly   550 --------------------------------EQW------------KLAKLSFNMWGA------ 564
                                            |::            :|.|:||...||
  Rat   603 RRPAGEGGEVPEGPRGGKEEDEEEDDDDEDEDEEYEGEEGSLLDCGLRLKKVSFAERGAGRRRPG 667

  Fly   565 ---------LSPTQNVTR-------SLAEELATAEAELKAESTGTPTKS---------------- 597
                     .|||. |.:       :||||  ..|.|....|.|...::
  Rat   668 PSPDGLLEEGSPTM-VEKGLEPGVFTLAEE--DDEPEAPPSSPGPEPQTVLLRRAGGEGRDQGSD 729

  Fly   598 --QQPESSS-------KRN----------------IGQAEIESSLYKYDGTFSDHLEMLVQMGYV 637
              :.||:.|       ||:                :.|||:||.:.||:.||.|:.||.||.|||
  Rat   730 GDRDPETGSGDAAGRQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYV 794

  Fly   638 VLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIVNCAL 702
            ||||:|||||.:|||:|||:|||||||||....||||||||.:||.||..:..:.:.|::|||.|
  Rat   795 VLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYL 859

  Fly   703 IGLSGQVSRLWPGLTTAQTIILIVTLEHIMLGLRQALTWLLPELPSWLAAEIARAEHCRRE 763
            ||..||:.||:|.|:....|:.:|.|||:.|.::..:...:|::|.|:|.|:|:.|:.|||
  Rat   860 IGQCGQLQRLFPWLSPEAAIVSVVVLEHLALLVKYLIHAAIPDIPGWVAEEMAKLEYQRRE 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wwk	NP_609738.1	Anoctamin	289..756	CDD:461349	233/692 (34%)
Ano8	XP_038950925.1	Anoctamin	237..>539	CDD:461349	132/315 (42%)
		Anoctamin	<744..913	CDD:461349	79/168 (47%)
		PRK12323	<961..>1139	CDD:481241