DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and Ano10

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	XP_038938700.1	Gene:	Ano10 / 301111	RGDID:	1308260	Length:	712	Species:	Rattus norvegicus

Alignment Length:	798	Identity:	254/798 - (31%)
Similarity:	390/798 - (48%)	Gaps:	144/798 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DFTDDNNFES------NLRRRKGKIISCAKETIENASRQLRRKVPYAGHLMTPRRLWLNKIPTQC 108
            |:|.:.|.|.      :|.:.|| |:|.. :|.|::              .||.
  Rat     5 DWTGNPNVEERPVHGVSLSKMKG-ILSTV-DTCESS--------------FTPL----------- 42

  Fly   109 DVVIEFPEDAPDEALRWLLARIRSQPPAG------LGLLVQVKAHESTRRNAFYVSAPVNVLFKA 167
             ||||..:|..:|...||.:||.|....|      ..||.:.:......:|.:.|.|....|...
  Rat    43 -VVIELAQDVKEETKEWLKSRIISPKKDGGAQLLFRPLLNKYEKETLENQNLYLVGASNIRLLLG 106

  Fly   168 AEEARLPKRLRPDLGGALREFTTRESHCFQQLRGDVGSTALFTSQERQWLVLQVLQGLRAGCSDI 232
            ||...|.|..   ..||:|.||.|..|.|:...|:  :....|..|.|:::...|:.|||....:
  Rat   107 AEAVGLVKEC---TDGAMRAFTYRTRHNFKGFHGN--NDDFLTMAECQFIIKHELENLRARDEKM 166

  Fly   233 EALHGRAAVAEGQSIVATWQESGLITQVFPLHEPSSLTQLQTHWVKQIFA--PQPLDDIAAYFGV 295
            ...:.:|.:..|:|::.....||::|||||||:..:|.:|:..|..: ||  .||:|.|..|||.
  Rat   167 IPGYPQAKLYPGKSLMRRLLTSGIVTQVFPLHDTEALKKLEDTWYTR-FALKYQPIDSIRGYFGE 230

  Fly   296 KVALYFAWLGHYTCALGVPAVFGTILYCILWGKGQTAQDMG-HVLFSLFNVAWASLYLEAWKRYS 359
            .:||||.:|.::|.||...||.|...|..:|      :|.. :|:|:.||:.|:::.||.|||..
  Rat   231 TIALYFGFLEYFTFALIPMAVIGLPYYLFVW------EDYDKYVIFASFNLIWSTVILEVWKRGC 289

  Fly   360 VELAFRWGTLSTPPELLEPPRPLYKGPLEENNVTGRLEPKEAPAWQRRAFRYLVSFPIIGCCLCV 424
            ..:.:|||||....: .|.|||.:.|.|..|:||||.||..: :::|:...||||.|.:  |||:
  Rat   290 ANMTYRWGTLVMKRQ-FEEPRPGFHGVLGINSVTGREEPVYS-SYKRQLRTYLVSLPFV--CLCL 350

  Fly   425 VFAVMFLMLRF--QDW-----------WDSKLPEESVLCCLSVIPKVLLAGAITLMDEAYFKLAV 476
            .|::..:|:.|  :||           |.|         .|..:|.::.|..|.:|:..|...|.
  Rat   351 YFSLYVMMIYFDMEDWALSLHEDSGSEWTS---------LLLYVPSIVYAIVIEIMNRLYRYAAE 406

  Fly   477 WLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAFYLRDEEKLKEQLAGLLISRQIIGNLR 541
            :|...||:||:|.|:|||:.||.:|.|:|.|.|||||||.|:|.:.|::.||.|||:.||:..:.
  Rat   407 FLTSWENHRLESAYQNHLVLKVLVFNFLNCFASLFYIAFVLKDMKLLRQSLATLLITSQILNQVV 471

  Fly   542 ESAIPYFLEQWKLAKLSFNMWGALSPTQNVTRSLAEELATAEAELKAESTGTPTKSQQPESSSKR 606
            ||.:||:|::...|::           :...|:|..::.|...|
  Rat   472 ESLLPYWLQRKYCARV-----------KRKVRALKSDVDTTLYE--------------------- 504

  Fly   607 NIGQAEIESSLYKYDGTFSDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQ 671
               |..:|..:..|.|||.|:||:.:|.|||.|||..:|||...|::||..|:.|||.|:..|.:
  Rat   505 ---QVLLEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFK 566

  Fly   672 RPFGQRVANIGTWQNALSILSLAAVIVNCALIGLSGQVSRLWPGLTTAQTIILIVTLEHIMLGLR 736
            |||.:..|:||.||.|...:|:.:|:.||||||:|.||:.::|...| ..::::|.:||.:|.|:
  Rat   567 RPFSEPSASIGVWQLAFETMSVISVVTNCALIGMSPQVNAVFPESKT-DLVLIVVAVEHALLALK 630

  Fly   737 QALTWLLPELPSWLAAEIAR-----------------AEHCRREMQ--------CKGTSPRPTPP 776
            ..|.:.:|:.|..:..::||                 ||..:.|.|        |:..:..|.|.
  Rat   631 FILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVAESLKEESQEEEKEAAACRMPATLPQPE 695

  Fly   777 TPQSTTSTQPEQEGPGGL 794
            ...:..:  |.|.|...|
  Rat   696 LRNNCIT--PGQGGDASL 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	172/499 (34%)
Ano10	XP_038938700.1	Anoctamin	224..650	CDD:398306	170/480 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0001419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100943
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720