DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and Ano3

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_001121575.1	Gene:	Ano3 / 228432	MGIID:	3613666	Length:	981	Species:	Mus musculus

Alignment Length:	897	Identity:	206/897 - (22%)
Similarity:	321/897 - (35%)	Gaps:	308/897 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NNFESNLRRRKGKIISCAKETIENASRQLRRKVPYAGHLMTPRRLWLNKIPTQCDVVIEFPEDAP 119
            |.||.|||                |...:..|.|   .:..|..::: ||....|.:.::.|
Mouse   181 NTFEKNLR----------------AEGLMLEKEP---AIANPDIMFI-KIHIPWDTLCKYAE--- 222

  Fly   120 DEALRWLLARIRSQPPAGLGLLVQVKAHESTRRNAFYVSAPVNVLFKAAEE------ARLPKRLR 178
                     |:..:.|      .:.|.:.:.::|.  ..:.|...||..::      ..|.|...
Mouse   223 ---------RLNIRVP------FRKKCYYTDQKNK--SKSRVQNYFKRIKKWMSQNPMVLDKSAF 270

  Fly   179 PDLGGALREFTTRESHCFQQ--LRGDV------GSTALFTSQERQWLVLQVLQGLR--AGCSDIE 233
            |:|         .||.|:..  .|..:      .....|::..|..:|..:|:..:  .|.|.:.
Mouse   271 PEL---------EESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVG 326

  Fly   234 ALHGRAAVAEGQSIVATWQESGLITQVFPLHE---PSSLTQLQTH------------------WV 277
            .   |..:..|..|.|           ||.||   .||| .::||                  |.
Mouse   327 I---RKLITNGSYIAA-----------FPPHEGAYKSSL-PIKTHGPQNNRHLLYERWARWGMWY 376

  Fly   278 KQIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGTILY---CILWGKGQTAQDM---- 335
            |.    ||||.|..|||.|:.|||||||.||..|...||.|..::   .:...:.|.:|::
Mouse   377 KH----QPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKAT 437

  Fly   336 ---------------------------------GHVLFSLFNVAWASLYLEAWKRYSVELAFRWG 367
                                             |.|.|::|...||:::||.|||....|.:.|.
Mouse   438 EVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWD 502

  Fly   368 TLSTPPELLEPPRPLYKGPLEE----NNVTGRLEPKEAPAWQRRAFRYLVS----FPIIGCCLCV 424
            .:....| .|..||.::.....    |.:||:.||.:..:  .:..|.|||    |.:|...:..
Mouse   503 LIEWEEE-EETLRPQFEAKYYRMEVINPITGKPEPHQPSS--DKVTRLLVSVSGIFFMISLVITA 564

  Fly   425 VFAV----MFLMLRF---------QDWWDSKLPEESVLCCLSVIPKVLLAGAITLMDEAYFKLAV 476
            ||||    :.:|.:|         |.|   :........|::.|       .|.|::.||.|:|.
Mouse   565 VFAVVVYRLVVMEQFASFKWNFVKQHW---QFATSGAAVCINFI-------IIMLLNLAYEKIAY 619

  Fly   477 WLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAFYLR-------------DEEKLKE--- 525
            .|.:.|..|.:|::||....|:.||||||...|:|||||:|.             :..:|:|
Mouse   620 LLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEECHP 684

  Fly   526 ---------QLAGLLISRQIIGNLRESAIPYFLEQWKLAKLSFNMWGALSPTQNVTRSLAEELAT 581
                     |:..::..:||..|..|...|.....|...|:...:..|..|......:|
Mouse   685 SGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNL------ 743

  Fly   582 AEAELKAESTGTPTKSQQPESSSKRNIGQAEIESSLYKYDGTFSDHLEMLVQMGYVVLFSAAFPL 646
                             ||     .||            .|...::|||::|.|:..:|.|||||
Mouse   744 -----------------QP-----MNI------------HGLMDEYLEMVLQFGFTTIFVAAFPL 774

  Fly   647 AGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIVNCALIGLSG---- 707
            |.:.||:||::|||.||:|.....:||...|..:||.|...|..:.:.|||.|..:|.::.
Mouse   775 APLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIP 839

  Fly   708 ---------------------------------QVSRLWPGLT---------------------- 717
                                             .:|.|..|.:
Mouse   840 RFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTL 904

  Fly   718 -----TAQTIILIVTLEHIMLGLRQALTWLLPELPSWLAAEIARAEHCRREM 764
                 .|..:..|:..||::.|::..:.:|:|::|..|...|.|.::..:||
Mouse   905 QYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEM 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	150/618 (24%)
Ano3	NP_001121575.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..87
		Anoct_dimer	157..381	CDD:292796	51/267 (19%)
		Anoctamin	384..950	CDD:282414	150/618 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950