Protein Alignment wwk and ANO5

DIOPT Version :10

• Sequence 1: NP_609738.1
• Gene: wwk / 34886
• FlyBaseID: FBgn0028879
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: NP_998764.1
• Gene: ANO5 / 203859
• HGNCID: 27337
• Length: 913
• Species: Homo sapiens
• Alignment Length: 872
• Identity: 200/872 - (22%)
• Similarity: 322/872 - (36%)
• Gaps: 257/872 - (29%)

  Fly    83 LRRKVPYAGHLMTPRRLWLNKIPTQCDVVIEFPEDAPDEALRWLLARIRSQ-----PPAGLGLLV 142
            |||::.:..:..:...::......|.|.|:.:.:|...:|  .|.|..|.:     ...||.|.:
Human    55 LRRRLMFQKNQQSKDSIFFRDGIRQIDFVLSYVDDVKKDA--ELKAERRKEFETNLRKTGLELEI 117

  Fly   143 QVKAHESTRRNAFY-VSAPVNVLFKAAE---------EARLPKRLRPDLG---GALR-------- 186
            :.|......|..|. :.||..||...||         |:.:|:.....:.   |.:|
Human   118 EDKRDSEDGRTYFVKIHAPWEVLVTYAEVLGIKMPIKESDIPRPKHTPISYVLGPVRLPLSVKYP 182

  Fly   187 ---EFTTRESHCFQQLRGDVGSTALFTSQERQWLVLQVLQGLRAGCSDIEALHGRAAVAEGQSIV 248
               .||.:.|...|:|.........|.|..|..:|..:|.....|..|.:...|          :
Human   183 HPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVYYILSRCPFGIEDGKKRFG----------I 237

  Fly   249 ATWQESGLITQVFPLH--------EPSSLTQ----LQTHWVK--QIFAPQPLDDIAAYFGVKVAL 299
            .....|...:..:|||        ||.:.|.    |..:|.:  ..:..||||.|..|:|.|:.:
Human   238 ERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSYFYKEQPLDLIKNYYGEKIGI 302

  Fly   300 YFAWLGHYTCALGVPAVFGTILYCILWG------------------KGQ---------------- 330
            ||.:||.||..|...||.|  |.|.::|                  .||
Human   303 YFVFLGFYTEMLFFAAVVG--LACFIYGLLSMEHNTSSTEICDPEIGGQMIMCPLCDQVCDYWRL 365

  Fly   331 ----TAQDMGH-------VLFSLFNVAWASLYLEAWKRYSVELAFRWGTLSTPPELLE-PPRPLY 383
                .|....|       |.|::|...|.:|:||.||:....|.:.|..:....|..: ..||.:
Human   366 NSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRPEF 430

  Fly   384 KGPLEE---NNVTGRLEPKEAPAWQRRAFRYLVSFPI-IGCCLCVVFAVMFLMLR------FQDW 438
            :...:.   |.||..:|| ..|.:.|..:.:|....: :...|.|...|..::.|      |..:
Human   431 EAMCKHRKLNAVTKEMEP-YMPLYTRIPWYFLSGATVTLWMSLVVTSMVAVIVYRLSVFATFASF 494

  Fly   439 WDSKLPEESVLCCLSVIPKVLLAGA------ITLMDEAYFKLAVWLNDRENYRLQSKYENHLIAK 497
            .:|....:.|...|:......|.|:      |.:::..|.|::.|:...|..|...:||:.|..|
Human   495 MESDASLKQVKSFLTPQITTSLTGSCLNFIVILILNFFYEKISAWITKMEIPRTYQEYESSLTLK 559

  Fly   498 VALFQFVNSFLSLFYIAF-------------YL----RDEE--------KLKEQLAGLLISRQII 537
            :.||||||.:.|.||:||             ||    |.||        :|..||..::..:||.
Human   560 MFLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFNEWRSEECDPGGCLIELTTQLTIIMTGKQIF 624

  Fly   538 GNLRESAIPYFLEQWKLAKLSFNMWGALSPTQNVTRSLAEELATA-EAELKAESTGTPTKSQQPE 601
            ||::|:..|..|..|:..|               .|:.:|:|.:. |.:...||.| |.
Human   625 GNIKEAIYPLALNWWRRRK---------------ARTNSEKLYSRWEQDHDLESFG-PL------ 667

  Fly   602 SSSKRNIGQAEIESSLYKYDGTFSDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKL 666
                                |.|.::||.:.|.|:|.||.|:||||.:.|||||::|||.||:||
Human   668 --------------------GLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWKL 712

  Fly   667 AHVHQRPFGQRVANIGTWQNALSILSLAAVIVNCALIG----------------------LSGQV 709
            ...::|....:..:||.||:.|..:::.:|..|..::.                      ::|.|
Human   713 TTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYYAYSTNATQPMTGYV 777

  Fly   710 S---------------------------------------------RLWPGLTTAQTIILIVTLE 729
            :                                             :.|..|....|.|::  :|
Human   778 NNSLSVFLIADFPNHTAPSEKRDFITCRYRDYRYPPDDENKYFHNMQFWHVLAAKMTFIIV--ME 840

  Fly   730 HIMLGLRQALTWLLPELPSWLAAEIAR 756
            |::..::..|.|::|::|..:...|.|
Human   841 HVVFLVKFLLAWMIPDVPKDVVERIKR 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wwk	NP_609738.1	Anoctamin	289..756	CDD:461349	146/621 (24%)
ANO5	NP_998764.1	Anoct_dimer	72..289	CDD:465044	47/228 (21%)
		Anoctamin	292..868	CDD:461349	147/623 (24%)
		COG5594	<462..>583	CDD:227881	31/120 (26%)