DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and ANO5

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_998764.1	Gene:	ANO5 / 203859	HGNCID:	27337	Length:	913	Species:	Homo sapiens

Alignment Length:	872	Identity:	200/872 - (22%)
Similarity:	322/872 - (36%)	Gaps:	257/872 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 LRRKVPYAGHLMTPRRLWLNKIPTQCDVVIEFPEDAPDEALRWLLARIRSQ-----PPAGLGLLV 142
            |||::.:..:..:...::......|.|.|:.:.:|...:|  .|.|..|.:     ...||.|.:
Human    55 LRRRLMFQKNQQSKDSIFFRDGIRQIDFVLSYVDDVKKDA--ELKAERRKEFETNLRKTGLELEI 117

  Fly   143 QVKAHESTRRNAFY-VSAPVNVLFKAAE---------EARLPKRLRPDLG---GALR-------- 186
            :.|......|..|. :.||..||...||         |:.:|:.....:.   |.:|
Human   118 EDKRDSEDGRTYFVKIHAPWEVLVTYAEVLGIKMPIKESDIPRPKHTPISYVLGPVRLPLSVKYP 182

  Fly   187 ---EFTTRESHCFQQLRGDVGSTALFTSQERQWLVLQVLQGLRAGCSDIEALHGRAAVAEGQSIV 248
               .||.:.|...|:|.........|.|..|..:|..:|.....|..|.:...|          :
Human   183 HPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVYYILSRCPFGIEDGKKRFG----------I 237

  Fly   249 ATWQESGLITQVFPLH--------EPSSLTQ----LQTHWVK--QIFAPQPLDDIAAYFGVKVAL 299
            .....|...:..:|||        ||.:.|.    |..:|.:  ..:..||||.|..|:|.|:.:
Human   238 ERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSYFYKEQPLDLIKNYYGEKIGI 302

  Fly   300 YFAWLGHYTCALGVPAVFGTILYCILWG------------------KGQ---------------- 330
            ||.:||.||..|...||.|  |.|.::|                  .||
Human   303 YFVFLGFYTEMLFFAAVVG--LACFIYGLLSMEHNTSSTEICDPEIGGQMIMCPLCDQVCDYWRL 365

  Fly   331 ----TAQDMGH-------VLFSLFNVAWASLYLEAWKRYSVELAFRWGTLSTPPELLE-PPRPLY 383
                .|....|       |.|::|...|.:|:||.||:....|.:.|..:....|..: ..||.:
Human   366 NSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRPEF 430

  Fly   384 KGPLEE---NNVTGRLEPKEAPAWQRRAFRYLVSFPI-IGCCLCVVFAVMFLMLR------FQDW 438
            :...:.   |.||..:|| ..|.:.|..:.:|....: :...|.|...|..::.|      |..:
Human   431 EAMCKHRKLNAVTKEMEP-YMPLYTRIPWYFLSGATVTLWMSLVVTSMVAVIVYRLSVFATFASF 494

  Fly   439 WDSKLPEESVLCCLSVIPKVLLAGA------ITLMDEAYFKLAVWLNDRENYRLQSKYENHLIAK 497
            .:|....:.|...|:......|.|:      |.:::..|.|::.|:...|..|...:||:.|..|
Human   495 MESDASLKQVKSFLTPQITTSLTGSCLNFIVILILNFFYEKISAWITKMEIPRTYQEYESSLTLK 559

  Fly   498 VALFQFVNSFLSLFYIAF-------------YL----RDEE--------KLKEQLAGLLISRQII 537
            :.||||||.:.|.||:||             ||    |.||        :|..||..::..:||.
Human   560 MFLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFNEWRSEECDPGGCLIELTTQLTIIMTGKQIF 624

  Fly   538 GNLRESAIPYFLEQWKLAKLSFNMWGALSPTQNVTRSLAEELATA-EAELKAESTGTPTKSQQPE 601
            ||::|:..|..|..|:..|               .|:.:|:|.:. |.:...||.| |.
Human   625 GNIKEAIYPLALNWWRRRK---------------ARTNSEKLYSRWEQDHDLESFG-PL------ 667

  Fly   602 SSSKRNIGQAEIESSLYKYDGTFSDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKL 666
                                |.|.::||.:.|.|:|.||.|:||||.:.|||||::|||.||:||
Human   668 --------------------GLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWKL 712

  Fly   667 AHVHQRPFGQRVANIGTWQNALSILSLAAVIVNCALIG----------------------LSGQV 709
            ...::|....:..:||.||:.|..:::.:|..|..::.                      ::|.|
Human   713 TTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYYAYSTNATQPMTGYV 777

  Fly   710 S---------------------------------------------RLWPGLTTAQTIILIVTLE 729
            :                                             :.|..|....|.|::  :|
Human   778 NNSLSVFLIADFPNHTAPSEKRDFITCRYRDYRYPPDDENKYFHNMQFWHVLAAKMTFIIV--ME 840

  Fly   730 HIMLGLRQALTWLLPELPSWLAAEIAR 756
            |::..::..|.|::|::|..:...|.|
Human   841 HVVFLVKFLLAWMIPDVPKDVVERIKR 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	147/623 (24%)
ANO5	NP_998764.1	Anoct_dimer	72..289	CDD:374413	47/228 (21%)
ANO5	NP_998764.1	Anoctamin	292..868	CDD:367984	147/623 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950