Protein Alignment wwk and ANO6

DIOPT Version :10

• Sequence 1: NP_609738.1
• Gene: wwk / 34886
• FlyBaseID: FBgn0028879
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: NP_001191732.1
• Gene: ANO6 / 196527
• HGNCID: 25240
• Length: 931
• Species: Homo sapiens
• Alignment Length: 984
• Identity: 215/984 - (21%)
• Similarity: 356/984 - (36%)
• Gaps: 331/984 - (33%)

  Fly    16 QQQSSEDVPDSTATTTATSTAGELGGGPRDGGEDDFTDDNNFESNLRRRKGKIISCAKETIENAS 80
            |.:..||..|           |::|..|. ......|...:..|:|             .:||..
Human    11 QMEEEEDDDD-----------GDIGDVPA-SRRPFLTPHTHLPSSL-------------VLENLG 50

  Fly    81 RQLRRKVPYAGHLMT---------------PRRLWLNKIPTQCDVVIEFPEDAPDEA-LRWLLAR 129
            :.:   ||..|.|.:               |..|:.|....:.|.|:.:.:::..|. .:....:
Human    51 QTI---VPDLGSLESQHDFRTPEFEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEK 112

  Fly   130 IRSQPPA--------GLGL----------LVQVKAHESTRRNAFYVSAPVNVLFKAAEEARLPKR 176
            .|.:..|        ||.|          ||.||.|           ||..||...||...:...
Human   113 QRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVH-----------APWEVLCTYAEIMHIKLP 166

  Fly   177 LRP-DLG------GALREFT----TRESHC----------FQQLRGD----VGSTALFTSQERQW 216
            |:| ||.      |.|..||    ..||..          |::.|.:    |...|.|....|..
Human   167 LKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSR 231

  Fly   217 LVLQVLQGLRAGCSDIEALHGRAAVAEGQSIVATWQESGLITQVFPLHE------------PSSL 269
            :|..:|..::     .:.::..:.....:.:     .||:....||||:            |:..
Human   232 IVYFILSRVK-----YQVINNVSKFGINRLV-----NSGIYKAAFPLHDCKFRRQSEDPSCPNER 286

  Fly   270 TQLQTHWV--KQIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGT--ILY-------- 322
            ..|...|.  :.|:..||||.|..|:|.|:.:||||||:||..|.:.||.|.  .||
Human   287 YLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNC 351

  Fly   323 ------------------------CILWGKGQTAQ---------DMGHVLFSLFNVAWASLYLEA 354
                                    |..|....|.:         ..|.::|::|...|.:|:||.
Human   352 TWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEF 416

  Fly   355 WKRYSVELAFRWGTLSTPPELLEPPRPLYKGPLEE---NNVTGRLEPKEAPAWQRRAFRYLVSFP 416
            |||...||.:.|.|:....|  |..||.|:.....   |.:|...|.....||.:.....|.:..
Human   417 WKRRQAELEYEWDTVELQQE--EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASA 479

  Fly   417 IIGCCLCVVFAVM-FLMLRFQDW--WDSKLPEE-----------SVLCCLSVIPKVLLAGAITLM 467
            :....|.::.:|: .::.|...:  :.:|||:.           :.....|:...::....|.::
Human   480 VFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMIL 544

  Fly   468 DEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAFY---------------- 516
            :..|.|:|:.:.:.|..|.|:.|||.|..|:.||||||.:.|.|||||:
Human   545 NTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLG 609

  Fly   517 -LRDEE--------KLKEQLAGLLISRQIIGNLRESAIPYFLEQWKLAKLSFNMWGALSPTQNVT 572
             .|:||        :|..||..::..:.|..|::|..:|:.:          |:.|.....
Human   610 KYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIM----------NLIGRFHRV---- 660

  Fly   573 RSLAEELATAEAELKAESTGTPTKSQ----QPESSSKRNIGQAEIESSLYKYDGTFSDHLEMLVQ 633
             |.:|::             ||...|    ||       :|:.          |.|.::|||::|
Human   661 -SGSEKI-------------TPRWEQDYHLQP-------MGKL----------GLFYEYLEMIIQ 694

  Fly   634 MGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIV 698
            .|:|.||.|:||||.:.||:||::|||.||:||....:|...::..:||.||..:..:::.||:.
Human   695 FGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVT 759

  Fly   699 NCALIGL-SGQVSRL---W---------------------------------------------- 713
            |..:|.. |..:.||   |
Human   760 NAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNH 824

  Fly   714 -----------PG------------LTTAQTIILIVTLEHIMLGLRQALTWLLPELPSWLAAEIA 755
                       ||            ...|..:..|:.:||::..::..:::.:|::.....::|.
Human   825 TTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQ 889

  Fly   756 RAEHCRREM 764
            |.::..:::
Human   890 REKYLTQKL 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wwk	NP_609738.1	Anoctamin	289..756	CDD:461349	144/628 (23%)
ANO6	NP_001191732.1	Anoct_dimer	82..305	CDD:465044	49/243 (20%)
		Anoctamin	308..891	CDD:461349	144/629 (23%)