Protein Alignment wwk and Axs

DIOPT Version :10

• Sequence 1: NP_609738.1
• Gene: wwk / 34886
• FlyBaseID: FBgn0028879
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: XP_061513326.1
• Gene: Axs / 1279184
• VectorBaseID: AGAMI1_012520
• Length: 763
• Species: Anopheles gambiae
• Alignment Length: 746
• Identity: 239/746 - (32%)
• Similarity: 374/746 - (50%)
• Gaps: 112/746 - (15%)

  Fly    50 DFTDDNNFESNLRRRKGKI-ISCAKETIENASRQL-RRKVPYAGHLMTPRRLWLNKIPTQCDVVI 112
            |.:.:.|..:.||.|||.: |:..|.|.::.:|.. ..:.|:...||                ::
Mosquito    69 DHSGEQNKLNELRNRKGTVRINQPKVTRQDKARPPDDEQEPFGESLM----------------LL 117

  Fly   113 EFPEDAPDEALRWLLARIRS-QPPAGLGLLVQVK-AHESTRRNAFYVSAPVNVLFKAAEEARLPK 175
            ||.|:||.||::|::.:||. :...|:.|:|:.: ..:.::...|::||....|.:.|::....|
Mosquito   118 EFGENAPVEAIQWIMDKIRGRRVDGGMELMVRKEPLSKDSKTIIFHLSATHMKLLEIADDMGFMK 182

  Fly   176 RLRPDLGGALREFTTRESHCFQQLRGDVGSTAL---FTSQERQWLVLQVLQGLRAGCSDIEALHG 237
            |.:   .|.:|.|...   |..:...| .|.||   .|..:||.:|...|:.::|...:......
Mosquito   183 RTK---SGIIRNFNVA---CLDEFFYD-ESMALEDILTPADRQIIVKHALETIKAADDEHRIPGT 240

  Fly   238 RAAVAEGQSIVATWQESGLITQVFPLHEPSSLTQLQTHWVKQIFAPQPLDDIAAYFGVKVALYFA 302
            :..:..||||:...|.:.|||.::.||:..:|.:|:..|:|.. ..||:|:|..|||..|.:||:
Mosquito   241 KIILYHGQSIIQAAQSAELITNLYSLHDKRTLKELRHRWIKPT-RVQPIDEIRDYFGESVGMYFS 304

  Fly   303 WLGHYTCALGVPAVFGTILYCILWGKGQTAQDMGHVLFSLFNVAWASLYLEAWKRYSVELAFRWG 367
            :||.||.||.||.|||.:..      |.:.:......|.:|.|.|..::||.|||.|...|:|||
Mosquito   305 FLGFYTYALVVPTVFGFLQL------GLSEETETVPFFCVFYVVWMKVFLELWKRKSSSHAYRWG 363

  Fly   368 TLSTPPELLEPPRPLYKGPLEENNVTGRLEPKEAPAWQRRAFRYLVSFPIIGCCLCVVFAVMFLM 432
            |::...  |:.|||.|.|.|..:.:||:..| :.|.|:.....|.|:.|||..|:.:...|..
Mosquito   364 TITMTN--LDEPRPGYYGKLARDPITGKWTP-QYPKWKTYVQMYCVTAPIIMLCMGIAAFVTI-- 423

  Fly   433 LRFQDWWDSKL-----PEESVLCCLSVIPKVLLAGAITLMDEAYFKLAVWLNDRENYRLQSKYEN 492
              ||.:.::.|     |:..:|    .:|.|:.|..|.:...||.:||.:|.|:||:|.||:||.
Mosquito   424 --FQFYVEAYLAELFGPDAYIL----YLPSVVNAIYIAVSTLAYDRLATYLTDKENHRTQSQYER 482

  Fly   493 HLIAKVALFQFVNSFLSLFYIAFYLRDEEKLKEQLAGLLISRQIIGNLRESAIPYF--------- 548
            |.:.|:.:.:|||:||.||||||.|:|.:.||.||...||..|.:.|:.|:..||.
Mosquito   483 HRVNKLIVLEFVNNFLCLFYIAFILQDMKMLKTQLMMQLIVLQFLQNVFENLYPYLKKKVGLKIV 547

  Fly   549 -------LEQWKLAKLSFNMWGALSPTQNVTRSLAEELATAEAELKAESTGTPTKSQQPESSSKR 606
                   .|:.|||..|::..|        .|||.|:                    .|.....|
Mosquito   548 RLFVKSNYEKLKLAHESYDEMG--------LRSLDED--------------------DPRVVQNR 584

  Fly   607 NIGQAEIESSLYKYDGTFSDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQ 671
            .      |:.|.:|: |:.|:||:.:|.|||||||:..||....|::||::|||.||:||....:
Mosquito   585 K------EAILEEYN-TYDDYLELYIQFGYVVLFSSVAPLTAFWAILNNVIEIRLDAYKLCSFFK 642

  Fly   672 RPFGQRVANIGTWQNALSILSLAAVIVNCALIGLSGQVSRLWPGLTTAQTIILIVTLEHIMLGLR 736
            |||.:|..|||.||.|...|::.:::.||.::.||..:..|..|||.....:..:.:||::||
Mosquito   643 RPFARRTKNIGAWQLAFETLAVISILTNCGILYLSPHMRELGAGLTREAYTLTFLIIEHVLLG-- 705

  Fly   737 QALTWL----LPELPSWLAAEIARAEHCRRE 763
              |||.    :|:.|.|:...:|:|||..|:
Mosquito   706 --LTWFIYKAIPDTPHWVRVALAKAEHESRQ 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wwk	NP_609738.1	Anoctamin	289..756	CDD:461349	169/491 (34%)
Axs	XP_061513326.1	None