Protein Alignment CG15270 and ANO4

DIOPT Version :9

• Sequence 1: NP_609738.1
• Gene: CG15270 / 34886
• FlyBaseID: FBgn0028879
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: XP_011536213.1
• Gene: ANO4 / 121601
• HGNCID: 23837
• Length: 1121
• Species: Homo sapiens
• Alignment Length: 995
• Identity: 215/995 - (21%)
• Similarity: 351/995 - (35%)
• Gaps: 344/995 - (34%)

  Fly     8 RDGVPFSE----QQQSSEDV----------------------PDSTATTTATSTAGELGGGPRDG 46
            :..|.|||    .|:.::||                      |.:..:|:..::..|.||
Human   205 KSDVDFSEILNAIQEMAKDVNILFDELEAVSSPCKDDDSLLHPGNLTSTSDDASRLEAGG----- 264

  Fly    47 GEDDFTDDNNFESNLRRRKGK-----IISCAKETIENASRQL-RRKVPYAGHLMTPRRLWLNKIP 105
               :...:.|..:.|..|.||     |:...|...:...|:: .|.:...|..|......:|.
Human   265 ---ETVPERNKSNGLYFRDGKCRIDYILVYRKSNPQTEKREVFERNIRAEGLQMEKESSLINS-- 324

  Fly   106 TQCDVVIEFPEDAPDEALRWLLARIRSQPPAGLGLLVQVKAHESTRRNAFYVSAPVNVLFKAAEE 170
               |::. ....||.|.|.....::..:.|              .||..:|:......:.:..::
Human   325 ---DIIF-VKLHAPWEVLGRYAEQMNVRMP--------------FRRKIYYLPRRYKFMSRIDKQ 371

  Fly   171 ------------ARLPKRLRPDLGGALREFTTRESHCF------QQLRGDV--GSTALFTSQERQ 215
                        .||.|...|||         .|:.|:      |::...:  .....|.:..|.
Human   372 ISRFRRWLPKKPMRLDKETLPDL---------EENDCYTAPFSQQRIHHFIIHNKETFFNNATRS 427

  Fly   216 WLVLQVLQGLRAGCSDIEALHGRAAVAEGQSIVATWQ--ESGLITQVFPLHEPS--SLTQLQTH- 275
            .:|..:||              |....||::.:...:  .:|.....|||||.|  |...::||
Human   428 RIVHHILQ--------------RIKYEEGKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHG 478

  Fly   276 -----------------WVKQIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGTILYC 323
                             |.|.    ||||.:..|||.|:.|||||||.||..|...|..|  |:.
Human   479 AENHRHLLYECWASWGVWYKY----QPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIG--LFV 537

  Fly   324 ILWG-----KGQTAQDM-------------------------------------GHVLFSLFNVA 346
            .|:|     ..|.::::                                     ..|.|::|...
Human   538 FLYGVTTLDHSQVSKEVCQATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAV 602

  Fly   347 WASLYLEAWKRYSVELAFRWGTLSTPPELLEPPRPLYKGPLEE----NNVTGRLEPKEAPAWQRR 407
            ||:::||.|||....:|:.|..:....| .|..||.::....:    |.::|:.||.:  |:..:
Human   603 WATVFLEFWKRRRAVIAYDWDLIDWEEE-EEEIRPQFEAKYSKKERMNPISGKPEPYQ--AFTDK 664

  Fly   408 AFRYLVSFPIIGCCLCVVFAVMFLMLRFQ----------DWW----DSKLPEESVLCCLSVIPKV 458
            ..|.:||...|...:|||.|.:|.::.::          .|.    :|::.......|::..
Human   665 CSRLIVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWALIRNNSQVATTGTAVCINFC--- 726

  Fly   459 LLAGAITLMDEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAF-------- 515
                .|.|::..|.|:|:.|.:.|..|.:|::||....|:.||||||...|.|||||
Human   727 ----IIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGH 787

  Fly   516 ---YLR--DEEKLKE------------QLAGLLISRQIIGNLRESAIPYFLEQWKLAKLSFNMWG 563
               |||  :..:|:|            |:..:::.:|...|..|...|.....|...|:
Human   788 PGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKV------ 846

  Fly   564 ALSPTQNVTRSLAEELATAEAELKAESTGTPTKSQQPESSSKRNIGQAEIESSLYKYDGTFSDHL 628
                                    .:..|...|...|:.....|:      ..:..| |.|.::|
Human   847 ------------------------RQEHGPERKISFPQWEKDYNL------QPMNAY-GLFDEYL 880

  Fly   629 EMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILSL 693
            ||::|.|:..:|.||||||.:.||:||::|||.||:|.....:||...|..:||.|...|..:.:
Human   881 EMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGI 945

  Fly   694 AAVIVN----------------------CALIGLSGQ------------VSRL------------ 712
            .:||.|                      ||..|.:||            |.|:
Human   946 LSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESD 1010

  Fly   713 ---------------------------------WPGLTTAQTIILIVTLEHIMLGLRQALTWLLP 744
                                             |..|  |..:..|:..||::..::..:::|:|
Human  1011 GSEFSGTPLKYCRYRDYRDPPHSLVPYGYTLQFWHVL--AARLAFIIVFEHLVFCIKHLISYLIP 1073

  Fly   745 ELPSWLAAEIARAEHCRREM 764
            :||..|...:.|.::..:||
Human  1074 DLPKDLRDRMRREKYLIQEM 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	147/632 (23%)
ANO4	XP_011536213.1	Anoct_dimer	277..502	CDD:292796	49/271 (18%)
		Anoctamin	505..1087	CDD:282414	147/632 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950