DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and Ano1

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	XP_006508521.1	Gene:	Ano1 / 101772	MGIID:	2142149	Length:	1066	Species:	Mus musculus

Alignment Length:	1006	Identity:	215/1006 - (21%)
Similarity:	344/1006 - (34%)	Gaps:	378/1006 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GGPRDGGE-----DDFTDDNNFESNLRRRKGKIISCAKETIENASRQLRRKVPYAGHLMTPRRLW 100
            |.|.|.|.     |...||..|                           |:..|.|:|:
Mouse   163 GSPVDAGSPEVPMDYHEDDKRF---------------------------RREEYEGNLL------ 194

  Fly   101 LNKIPTQCDVVIEFPEDAPDEALRWLLARIRSQPPAGLGLLVQVKAHESTRRNAFYVSAPVNVLF 165
                  :..:.:|..||          .:|.     |:|.   ||.|           ||.:||.
Mouse   195 ------EAGLELENDED----------TKIH-----GVGF---VKIH-----------APWHVLC 224

  Fly   166 KAAE--EARLPKR-------------------------LRPDLGGALREFTTRESHCF----QQL 199
            :.||  :.::|.:                         ::|.:.....:.|.|.|:.|    |.|
Mouse   225 REAEFLKLKMPTKKVYHISETRGLLKTINSVLQKITDPIQPKVAEHRPQTTKRLSYPFSREKQHL 289

  Fly   200 RGDVGSTALFTSQERQWLVLQVLQGLRAGCSDIEALHGRAAVAEGQ------------------- 245
            .......:.|.|:.|..:|.::|:  |..|:..:...|:   .||:
Mouse   290 FDLTDRDSFFDSKTRSTIVYEILK--RTTCTKAKYSMGQ---GEGRRKDSALLSKRRKCGKYGIT 349

  Fly   246 SIVATWQESGLITQVFPLH---------EPSSLTQLQTHWVKQ--IFAPQPLDDIAAYFGVKVAL 299
            |::|    :|:.:..:|||         |.:....|...|...  .:..||:|.:..|||.||.|
Mouse   350 SLLA----NGVYSAAYPLHDGDYEGDNVEFNDRKLLYEEWASYGVFYKYQPIDLVRKYFGEKVGL 410

  Fly   300 YFAWLGHYTCALGVPAVFGTILY--------------------------------CILWGKGQ-- 330
            ||||||.||..|...::.|.|::                                |..|....
Mouse   411 YFAWLGAYTQMLIPASIVGVIVFLYGCATVDENIPSMEMCDQRYNITMCPLCDKTCSYWKMSSAC 475

  Fly   331 -TAQ------DMGHVLFSLFNVAWASLYLEAWKRYSVELAFRWGTLSTPPE---LLEPPRPLYKG 385
             ||:      :...|.||:|...||:.::|.|||..:.|.:||.......|   :.:.||..|:.
Mouse   476 ATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEA 540

  Fly   386 --------------------PLEENN---------VTG-RLEPKEAPAWQRRAFRYLVSFPIIGC 420
                                |.|..|         :.| :|..|....|:.|...|..:...|..
Mouse   541 RVLEKSLRKESRNKEKCRNVPEEPTNKWKQRVRTAMAGVKLTDKVKLTWRDRFPAYFTNLVSIIF 605

  Fly   421 CLCVVFAVMFLMLRFQDWWDSKLPEESVLCCLSVIPKVLLAGA-------ITLMDEAYFKLAVWL 478
            .:.|.||::..::.::....:.|...|.....|.|...:.|.|       |.|:||.|..:|.||
Mouse   606 MIAVTFAIVLGVIIYRISTAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWL 670

  Fly   479 NDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAFY-----------------LRDEE----- 521
            ...|..:.:..:|..|..|..|.:||||:..:||:||:                 .|.||
Mouse   671 TKIEVPKTEKSFEERLTFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGG 735

  Fly   522 ---KLKEQLAGLLISRQII-GNLRESAIP---YFLEQWKLAKLSFNMWGALSPTQNVTRSLAEEL 579
               :|..||:.:::.:|:| .||.|..||   .|:...||.:.|
Mouse   736 CLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKFIRYLKLRRQS--------------------- 779

  Fly   580 ATAEAELKAESTGTPTKSQQPESSSKRNIGQAEIESSLYKYDGTFSDHLEMLVQMGYVVLFSAAF 644
                          |:..::.....:|    .|::.:|..:.|...:::||::|.|:|.||.|:|
Mouse   780 --------------PSDREEYVKRKQR----YEVDFNLEPFAGLTPEYMEMIIQFGFVTLFVASF 826

  Fly   645 PLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIVNCALI------ 703
            |||.:.||:||::|||.||.|.....:||...|..:||.|.|.|..:...|||:|..:|
Mouse   827 PLAPLFALLNNIIEIRLDAKKFVTELRRPVAIRAKDIGIWYNILRGVGKLAVIINAFVISFTSDF 891

  Fly   704 --------------------------------------------GLSGQVSR------------- 711
                                                        |...|:.|
Mouse   892 IPRLVYLYMYSQNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSEHK 956

  Fly   712 ------LWPGLTTAQTIILIVTLEHIMLGLRQALTWLLPELPSWLAAEIAR-----AEHCRREMQ 765
                  .|..|  |..:..::..:::::.:...:.|::|::|..::.:|.:     .|...||.|
Mouse   957 YDISKDFWAVL--AARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQ 1019

  Fly   766 CK---------GTSPRPTPPTPQSTTSTQPE 787
            .|         ...||..|....|.| |.||
Mouse  1020 GKQQLLDTWMEKEKPRDVPCNNHSPT-THPE 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	145/652 (22%)
Ano1	XP_006508521.1	Anoct_dimer	112..397	CDD:374413	55/310 (18%)
Ano1	XP_006508521.1	Anoctamin	400..1006	CDD:367984	145/646 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950