Protein Alignment wwk and ano5a

DIOPT Version :10

• Sequence 1: NP_609738.1
• Gene: wwk / 34886
• FlyBaseID: FBgn0028879
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: XP_021326432.1
• Gene: ano5a / 100534737
• ZFINID: ZDB-GENE-091013-2
• Length: 931
• Species: Danio rerio
• Alignment Length: 989
• Identity: 210/989 - (21%)
• Similarity: 359/989 - (36%)
• Gaps: 351/989 - (35%)

  Fly    17 QQSSEDVPDSTATTTATSTAGELGGGPRDGGEDDFTDDNNFESNLRRRKGKIISCAKETIENASR 81
            |:||::.....:.|..:|            ||    |:|.|.||          ..|||.:..:.
Zfish     6 QKSSDETLIEMSRTAWSS------------GE----DNNGFHSN----------SDKETFQLENA 44

  Fly    82 QLRRKVPYAGHLMTPRRLWL---NKIPTQ---------------CDVVIEFPEDAPDE----ALR 124
            ::.||          |.|:|   :::..|               .|.|:.:.:|...|    ..:
Zfish    45 EIWRK----------RALFLKYRSRVDKQQQSKDSVYFRDGVRRIDFVLSYIDDKDGEKKQDRRK 99

  Fly   125 WLLARIRSQPPAGLGLLVQVKAHESTRRNAFY-VSAPVNVL------------FKAAE------- 169
            ...|.::.   |||.:..:.|:.....:..|. :..|..||            |||.:
Zfish   100 VFEANLQK---AGLEVETEDKSESEDGKTYFLKIHVPWEVLATYADVLKIKVPFKANDIPENKEI 161

  Fly   170 -------EARLPKRL---RPDLGGALREFTTRESHCFQQLRGDV----GSTALFTSQERQWLVLQ 220
                   ..|||..:   .||.      ||:    .|.:.:.|.    ....||.:..|..:|..
Zfish   162 PMGWLFTPFRLPDHVMNPEPDF------FTS----TFDKSKIDFFLIEDKETLFPASTRNRIVYY 216

  Fly   221 VLQGLRAGCSDIEALHGRAAVAEGQSIVATWQESGLITQVFPLHE------------PSSLTQLQ 273
            :|..:.....|           :.:..:.....:|..|..||||:            .|....|.
Zfish   217 LLSRIPYSTED-----------KDKKGIKRLLNNGTYTSAFPLHDCRYWTRSRDDNCESERYSLY 270

  Fly   274 THWVK--QIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGTILYCILWG--------- 327
            .:|.:  ..:..|||:.|..|:|.|:.:||||||.||..|...||.|  |.|.::|
Zfish   271 KNWARFSSFYKEQPLNLIRKYYGEKIGIYFAWLGFYTEMLSYAAVVG--LLCFIYGVATFDENIW 333

  Fly   328 ---------KGQTA---------------------------QDMGHVLFSLFNVAWASLYLEAWK 356
                     .||..                           .:...|.|::|...|.:|:||.||
Zfish   334 SREICNETIGGQIVMCPLCDKKCGYWKLSTTCSSSWQSYLFDNAATVFFAIFMGIWVTLFLEFWK 398

  Fly   357 RYSVELAFRWGTLSTPPELLE-PPRPLYKGPLEE---NNVTGRLE--PKEAPAWQRRAFRYLVSF 415
            |....|.:.|..:....|..: ..||.|:.....   |.||...|  ..:.||  .:|.|:::.:
Zfish   399 RRQARLEYEWDLVDFEEEQQQLQLRPEYESKCTNRRLNRVTQEQEWVLDQTPA--DKAGRFVLCW 461

  Fly   416 PIIGCCLCVVFAVMFLMLRF------------QDWWDSKL--------PEESVLCCLSVIPKVLL 460
            ..:...:.::.|.:..::.:            :|...:||        |:.:.....|.|..|:
Zfish   462 TTVLLWISLIIASIIGVIAYRLAVFAAFASIMKDSPTNKLEIVGNLITPQFATSVTASCINFVI- 525

  Fly   461 AGAITLMDEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAFY--------- 516
               |.:::..|.::|:.:.|.|..:...:|||.|..|:.||||||.:.|.||:||:
Zfish   526 ---IMVLNFLYERVAIKITDMEVPKTHVEYENKLTIKMFLFQFVNYYSSCFYVAFFKGKFVGYPG 587

  Fly   517 -----------LRDEE--------KLKEQLAGLLISRQIIGNLRESAIPYFLEQWKLAKLSFNMW 562
                       ||:||        :|..||..:::.:|:.||::|:.:|: |..|         |
Zfish   588 NYAYMFGPWSGLRNEECEPGGCLIELTTQLVIVMVGKQVWGNIQEALVPW-LRNW---------W 642

  Fly   563 GALSPTQNVTRSLAEELATAEAELKAESTGTPTKSQQPESSSKRNIGQAEIESSLYKYDGTFSDH 627
                    |:||             |.:......|:..:....:|:||.          |.|.::
Zfish   643 --------VSRS-------------ARNHPESLYSRWEQDHDLQNLGQL----------GLFYEY 676

  Fly   628 LEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILS 692
            |||::|.|::.||.|:||||.:.||:||::|:|.||:|.....:||...:..:||.|:..|::::
Zfish   677 LEMVIQFGFITLFVASFPLAPLLALMNNILEVRVDAWKFTTQFRRPVAAKAHSIGAWEEILNMIA 741

  Fly   693 LAAVIVNCALIGL-SGQVSRL-------------------------------------------W 713
            :.:|:.|..::.. |..:.||                                           |
Zfish   742 VFSVVTNAFIVSFTSDMIPRLVYQYVHNTGNAASMSGYITHSLSIYNISEFPPENRPDDDENPDW 806

  Fly   714 -----------------PGLTTAQT------------IILIVTLEHIMLGLRQALTWLLPELPSW 749
                             ||.....|            :..|:.:||::..::..:.||:|::||.
Zfish   807 FNAGNYTTCRYRDYRYPPGHEKQYTHNMDFWHILAAKLAFIIIMEHVVFVVKFFVAWLIPDVPSD 871

  Fly   750 LAAEIARAEHCRRE 763
            :.|.:.|..:..:|
Zfish   872 VKARVKRERYLIQE 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wwk	NP_609738.1	Anoctamin	289..756	CDD:461349	144/638 (23%)
ano5a	XP_021326432.1	Anoct_dimer	71..285	CDD:465044	41/237 (17%)
		Anoctamin	288..879	CDD:461349	144/639 (23%)