DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and ano7

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	XP_031761694.1	Gene:	ano7 / 100494676	XenbaseID:	XB-GENE-6465418	Length:	932	Species:	Xenopus tropicalis

Alignment Length:	858	Identity:	220/858 - (25%)
Similarity:	335/858 - (39%)	Gaps:	269/858 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 GLLVQVKAHESTRRNAFY--VSAPVNVLFKAAEE--ARLPKRLRPDLGGALREFTTRESHCFQQ- 198
            |:|.:.:...|.||...|  :|||..:|...|||  .|.|.:.:|:.       .|..||.|.|
Frog   131 GVLCEKEQTLSERRCLHYMKLSAPWELLVYYAEEMCMRAPLQAQPNP-------DTNSSHRFLQW 188

  Fly   199 ---------------------------LRGDVGS---TALFTSQERQWLVLQVLQGLRAGCSDIE 233
                                       |:..:||   ...|::.:|..::.::|.         .
Frog   189 LRLPNPMYQHVPNKPLDYYTCAFRRSKLQKFLGSECPATYFSNTQRSRILYEILS---------R 244

  Fly   234 ALHGRAAVAEGQSIVATWQESGLITQVFPLHE-----------PSSLTQ---LQTHWVK--QIFA 282
            |::|:...|| ..|....|| |:.:..|||||           |.||..   |..:|.:  |.:.
Frog   245 AVYGKRKHAE-VGIERLLQE-GIYSAAFPLHEGAHEMPEYQVPPESLNPRQILSQYWARWSQWYK 307

  Fly   283 PQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGTILY---CILWGKGQTAQDM--------- 335
            .||||.|..|||.|||:||||||.||..|...|:.||:::   .:..|....||.:
Frog   308 YQPLDHIRDYFGEKVAIYFAWLGFYTAWLLPAAIVGTVVFISGLVSMGSNTAAQQICQSGQQYRM 372

  Fly   336 ----------------------------GHVLFSLFNVAWASLYLEAWKRYSVELAFRWGTLSTP 372
                                        |.|.||:|...||..:||.|||.:..||..|..:...
Frog   373 CPLCDTCKNWFISDICPMAKVGYLFDHPGTVFFSVFMSFWAVTFLEYWKRKNATLAHHWDCMDFQ 437

  Fly   373 PELLEPPRPLYKG---PLEENNVTGRLEPKEAPAWQRRAFRYLVSFPIIGCCLCVV--FAVMFLM 432
            .| .|.|||.:..   .:|:|.:||..||....  :.|..|.|....:|...||||  |.|..:|
Frog   438 EE-EEQPRPEFAAMAPQMEQNPITGVKEPYFPK--RDRLSRVLTGSMVIIIMLCVVMIFLVSVIM 499

  Fly   433 LR------FQDWWDSKLPEES---VLCCLSVIPKVLLAGAITLMDEAYFKLAVWLNDRENYRLQS 488
            .|      .....:|.|..::   .....|::..||    |.||.:.|..||..|...|.:|.||
Frog   500 YRGIVTMMMYHTGNSLLMTQAGNIANISSSMVNLVL----ILLMGQVYTSLAEKLTRWEMHRTQS 560

  Fly   489 KYENHLIAKVALFQFVNSFLSLFYIAFY----------------LRDEE--------KLKEQLAG 529
            ::|:....||.:|||||.:.|.||:||:                :|:|:        :|.:||..
Frog   561 RHEDAFTFKVFVFQFVNFYSSPFYVAFFKGRFIGYPGRYGKLLGMRNEDCGPGGCLIELAQQLFV 625

  Fly   530 LLISRQIIGNLRESAIPYFLEQWKLAKLSFNMWGALSPTQNVTRSLAEELATAEAELKAESTGTP 594
            :::.:||:.|::|..:|. |:.|:                 ..|.||:...|   :|:.|
Frog   626 IMVGKQIVSNIQEFLLPK-LKSWR-----------------QKRQLAKVRGT---QLREE----- 664

  Fly   595 TKSQQPESSSKRNIGQAEIESSLYKYDGTFSDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEI 659
                      .:..||   :..|.:.:|.|.::|||::|.|::.:|.||||||.:.||:||.:||
Frog   665 ----------PQRWGQ---DYELIECEGLFEEYLEMVLQFGFITIFVAAFPLAPLFALLNNWVEI 716

  Fly   660 RSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIVNCALIG------------------LS 706
            |.||.|....::||..:|...||.|...|..|:..:||||..||.                  ||
Frog   717 RLDAQKFVCEYRRPVAERAQGIGVWFLILEALAQLSVIVNAFLIAFTSDFLPRLLYQYEYNSDLS 781

  Fly   707 GQVS------------------------------RLWPGLTTAQTIILIVTLEHIMLGLRQALTW 741
            |.::                              .|:.....|..:..|:..||::....:.:.|
Frog   782 GYLNFTLAYSPRAYVSANHTVCRYKAFRDEDGNYTLFYWKLLAVRLGFIIAFEHVVFFSLRCIDW 846

  Fly   742 LLPELPSWLAAEIARAEHCRRE----------------------MQCKGTSPRP------TPPTP 778
            ::|::|..:..::.|..:..::                      ...:..||.|      |.|.|
Frog   847 MVPDIPESVEIKVKRERYLAKQALADTQEVPLTVSRGSSSAGSSSAARSMSPSPWAGGGVTRPEP 911

  Fly   779 QSTTSTQPEQEGP 791
            :.....|..|.||
Frog   912 KRGRDIQNWQLGP 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	160/594 (27%)
ano7	XP_031761694.1	Anoct_dimer	75..311	CDD:406563	47/197 (24%)
ano7	XP_031761694.1	Anoctamin	314..862	CDD:398306	159/593 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010