DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15270 and ano2

DIOPT Version :9

Sequence 1:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	XP_017948300.2	Gene:	ano2 / 100492483	XenbaseID:	XB-GENE-981445	Length:	1089	Species:	Xenopus tropicalis

Alignment Length:	977	Identity:	210/977 - (21%)
Similarity:	363/977 - (37%)	Gaps:	301/977 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GNEEVR-DGVPFSEQQQSSEDV--------------------PDSTATTTATS-TAGELGGGPRD 45
            ||::.: .|:.|.:.::..:.|                    |.:...:...| |..|:|..|:.
Frog   125 GNQQTKPSGMHFGDGKRKVDYVLAYHYRYRSSHHNGSPGSHRPPAVIVSNGNSITPEEVGKTPQQ 189

  Fly    46 GGEDDFTDDNNFESNLRRRKGKIISCAKETIENASRQLRRKVPYAGHLMTPRRLWLNKIPTQCD- 109
            ....|.....|.:.|:...: |..:......||.::                       |...|
Frog   190 SLPGDLHHQGNQKKNIHNHQ-KHNNSDHSHSENGNQ-----------------------PHHPDG 230

  Fly   110 -VVIEF-PEDAPDEALRWLLARIRSQP------PAGLGLLVQVKAHESTRRNAFYVSAPVNVLFK 166
             ||:|. ..||.:|.     .:|:.:.      .|||.|....:. :|...|...:.||..||.:
Frog   231 VVVVEINHHDALEEE-----KKIQREEFEQNLMEAGLELEKDPET-KSQGLNFVRIHAPWPVLSR 289

  Fly   167 AAE--EARLPKR----LRPDLGGALREFTTRESHCFQQLRGDV---------------------- 203
            .||  :.::|.:    ::.|. |.|::..:..:.|.:.|:..|
Frog   290 EAEFLKIKVPTKKMYEVKQDT-GILKKLYSLWNKCTKILQPKVPQFSENAKMKHLSYPFSRDKMH 353

  Fly   204 -----GSTALFTSQERQWLVLQVLQGLRAGCSDIEALHGRAAVAEGQSIVATWQESGLITQVFPL 263
                 .....|.:..|..:|.::|:    ..|.::|.:...        :.|...:.:....:||
Frog   354 LYDIKDKDTFFDNATRSRIVHEILK----RTSSVKAKYSMG--------ITTLIANNVYDSAYPL 406

  Fly   264 H---------EPSSLTQLQTHWVK--QIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVF 317
            |         |.:....|...|.:  ..:..||:|.|..|||.|:.|||||||.||..|...::.
Frog   407 HDGDYDHNKNETNERMLLHREWARYGAFYKYQPVDLIRKYFGEKIGLYFAWLGLYTWLLIPASLV 471

  Fly   318 GTILY--------------------------------CILW------GKGQTA---QDMGHVLFS 341
            |.|::                                |..|      |..:.:   .:...|.||
Frog   472 GIIVFLYGCATIDADIPSQEMCDQEQGFVMCPLCDKACDFWKLSSACGTARASHLFDNPATVFFS 536

  Fly   342 LFNVAWASLYLEAWKRYSVELAFRW---GTLSTPPELLEPPRPLYKGPL----EENNVTGRL-EP 398
            :|...||:|:||.|||..:.|::.|   |.......:.|.|||.|:..|    |::...|:. ..
Frog   537 VFMALWATLFLEYWKRLQMRLSYFWDLTGLEEEEERIKEHPRPEYETKLLLMKEKSKGNGKNGNK 601

  Fly   399 KEAPAWQRRAFRYLVSFPIIGCCLCVVFAVMFLMLRFQDWW-------DSKLPEESVLCCLSVIP 456
            ||...|:.|...|||:|..|...:.:.|:.:|.::.::...       .|::...:|...::...
Frog   602 KEKLTWRDRIPAYLVNFSAILFMIALTFSAVFGVIIYRITTAAALAVSTSEVTRSNVRVTVTATA 666

  Fly   457 KVLLAGAITLMDEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIAFY----- 516
            .::....|.::||.|..:|.||.:.|..:.:..:|..||.|..|.:||||:.|:||:||:
Frog   667 VIINLVVILILDEIYGSVAKWLTEIEVPKTEKTFEERLILKAFLLKFVNSYASIFYVAFFKGRFT 731

  Fly   517 ------------LRDEE--------KLKEQLAGLLISRQII-GNLRESAIPYFLEQWKLAKLSFN 560
                        .|.||        :|..||:.:::.:|:| .||.|.|||.|
Frog   732 GRPGSYAYIFHGYRMEECAPGGCLIELCIQLSIIMLGKQLIQNNLFEIAIPKF------------ 784

  Fly   561 MWGALSPTQNVTRSLAEELATAEAELKAESTGTPTKSQQPESSSKRNIGQAEIESSLYKYDGTFS 625
                    :.:.|...:|.|.     ..|:....||..|          |...:.:|..:.|...
Frog   785 --------KKLYRKFKDERAE-----PGENNLNNTKEPQ----------QWVRDYALEPFTGLTP 826

  Fly   626 DHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSI 690
            :::||::|.|:|.||.|:||||.:.||:||::|:|.||.|.....:||...|..:||.|.|.||.
Frog   827 EYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEVRLDAKKFVTELRRPDAVRAKDIGIWYNILSG 891

  Fly   691 LSLAAVIVNCALIGLSG-----------------------------QVSRLWPG----------- 715
            :...:||:|..:|.::.                             .||.|.||
Frog   892 IGKFSVIINAFVISVTSDFIPRLVYQYMYSENGTMHGFLNHTLSYFNVSHLKPGTQPENSQFAQN 956

  Fly   716 --------------------------LTTAQTIILIVTLEHIMLGLRQALTWLLPELPSWLAAEI 754
                                      ...|..:..::..:::::.|...:.||:|::|..::.:|
Frog   957 VEICRYKDYREPPSSPNQYDFSKQYWTILAVRLAFVILFQNLVMFLSAVVDWLIPDIPKDISEQI 1021

  Fly   755 AR 756
            .:
Frog  1022 KK 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	149/616 (24%)
ano2	XP_017948300.2	Anoct_dimer	235..440	CDD:406563	38/223 (17%)
ano2	XP_017948300.2	Anoctamin	443..1024	CDD:398306	149/616 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010