Protein Alignment CG15270 and ano8

DIOPT Version :9

• Sequence 1: NP_609738.1
• Gene: CG15270 / 34886
• FlyBaseID: FBgn0028879
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: XP_004911073.1
• Gene: ano8 / 100491780
• XenbaseID: XB-GENE-6044545
• Length: 1121
• Species: Xenopus tropicalis
• Alignment Length: 1302
• Identity: 379/1302 - (29%)
• Similarity: 538/1302 - (41%)
• Gaps: 398/1302 - (30%)

  Fly    65 KGKIISCAKETIENASRQ----------LRRKVPYAGHLMTPRRLWLNKIPTQ-CDVVIEFPEDA 118
            :||......|..|.|..|          ..:::..||..:|..:.|:..:||: ||||:.|.::.
 Frog     8 RGKKAQPEGERAEPAGSQHGTTGVLDKLFGKRLLQAGRYITSHKSWMRTVPTENCDVVMTFSDNT 72

  Fly   119 PDEALRWLLARIRSQPPAGLGLLVQVKAHESTRRNAFYVSAPVNVLFKAAEEARLPKRLRPDLGG 183
            .|..|.|||..:|...|.   |::|::.|..|...||:|:|....|.:.|||..|.|.::.:.||
 Frog    73 DDHTLLWLLNHVRLGLPE---LIMQIRHHRHTGIYAFFVTATYENLLRGAEEIGLRKPVKAEFGG 134

  Fly   184 ALREFTTRESHCFQQLRGDVGSTALFTSQERQWLVLQVLQGLRAGCSDIEALHGRAAVAEGQSIV 248
            ..|.|:..|.:.:|.:..::   ..|||||||.::...::.|||  ...|:|| .....|||.|:
 Frog   135 GTRVFSCEEDYIYQNIENEL---IFFTSQERQSIIRYWMENLRA--KQGESLH-NIHFLEGQPII 193

  Fly   249 ATWQESGLITQVFPLHEPSSLTQLQTHWVKQIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGV 313
            ......|:|.||||:||...|::|...||:.|...||||:|..|||||||:||:|:|.||.:|..
 Frog   194 PELTARGVIQQVFPIHEQRILSRLMRSWVQAICEKQPLDEICDYFGVKVAMYFSWMGFYTSSLVY 258

  Fly   314 PAVFGTILYCILWGKGQTAQDMGHVLFSLFNVAWASLYLEAWKRYSVELAFRWGTLSTPPELLEP 378
            |||||.:|:.|. ...||::|:..|:|:||||.||:|:||.|||...|||::||||.||.|.:|.
 Frog   259 PAVFGMMLWMIT-ESDQTSRDICCVVFALFNVVWATLFLEGWKRRGAELAYKWGTLDTPAEFIEE 322

  Fly   379 PRPLYKGPLEENNVTGRLEPKEAPAWQRRAFRYLVSFPIIGCCLCVVFAVMFLMLRFQDWWDS-- 441
            |||.::|....:.|| ..|....|.|:|..|:..||.|:...|||.||.||......|::..|
 Frog   323 PRPQFRGVKRISPVT-NCEEFYYPPWKRLLFQSFVSLPVCVSCLCFVFVVMLACFELQEFILSIK 386

  Fly   442 KLPEESVLCCLSVIPKVLLAGAITLMDEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNS 506
            :||.     .:...||:|||..::..||.|.|:|.||||.|||||||.||.|||.|:.|||||||
 Frog   387 ELPR-----VVRFFPKILLAVIVSSCDEVYRKIAYWLNDMENYRLQSAYEKHLIIKIVLFQFVNS 446

  Fly   507 FLSLFYIAFYLRDEEKLKE---------------------------------------------- 525
            :||||||.|||:|.|:|||
 Frog   447 YLSLFYIGFYLKDMERLKELFLVLSLPHSFTRQVKDALLPFLSLQFHLFLIVLRALLRSAWCLFK 511

  Fly   526 --QLAGLLISRQIIGNLRESAIPYFLEQ-----------W------------------------- 552
              .||.||:.||.:.|::|.:.|:..::           |
 Frog   512 SKMLATLLVIRQFLQNVKEVSQPHLYQKLQRGELTPRSVWLFVRYALKRLFQKYSLPQHPLRTPG 576

  Fly   553 ---------------------------------------------KLAKLSFNMWG------ALS 566
                                                         ||.::||...|      .|.
 Frog   577 NPMETGAGGRKKCLNGGCGVPEEEEGVVSEDEEEEEEESIMDCGLKLKRVSFLEKGERREDVGLV 641

  Fly   567 PTQN-----------------------------------------VTRSLAEELAT--------- 581
            |.|.                                         :...|.:|...
 Frog   642 PQQEDEGAFLQEGSPTLMERGSDPASVFQLEDEEDEEQEGASGGVLQEGLEQESGVKLRQHRRRR 706

  Fly   582 ----AEAELKAESTGTPTKSQQ--------PESSSKRNIGQAEIESSLYKYDGTFSDHLEMLVQM 634
                .|.|...|.....|:.:|        ||.:....:.|||:||.:.||:.||:|:.||.||.
 Frog   707 KRVILEEEQSREDEEDDTEMKQKRESWIDPPEDNYPTKLSQAEVESCMKKYEDTFNDYQEMFVQF 771

  Fly   635 GYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIGTWQNALSILSLAAVIVN 699
            |||||||:|||||.|||||||::|||||||||....|||||:||..||.|||.:..:.:.|:|||
 Frog   772 GYVVLFSSAFPLAAVCALINNIIEIRSDAFKLCTGLQRPFGRRVDGIGQWQNVMEAMGVIAIIVN 836

  Fly   700 CALIGLSGQVSRLWPGLTTAQTIILIVTLEHIMLGLRQALTWLLPELPSWLAAEIARAEHCRREM 764
            |.|:|..||:.||.|.|....|||.||.|||..|.|:..:..::|::|.|:|.|:|:.|:.|||.
 Frog   837 CYLMGQCGQLQRLLPWLGPETTIIFIVVLEHFALLLKYIIHVVIPDIPGWVAEEMAKLEYQRREA 901

  Fly   765 QCKGTSPRPTPPTPQSTTSTQPEQEGPGGLQMESGANTTRDQSMESQVAEDILLYGQEFAGYGHN 829
            ..|  ..|......|.....:.|:|     :.:..|:....:..||:..:|           |.|
 Frog   902 FKK--HERQAQHRYQQQQRRKREEE-----ERQRHADYHARKERESRGGDD-----------GKN 948

  Fly   830 IEADVNIYENRDSSPDSPPSQTSTILIRPLHESTPPHGGASLTSLHQDGNGGACQSWVKKSQMFI 894
            ...|...:|...|.               ..:..|| ||:|    |..
 Frog   949 SGQDSQNHEKNSSK---------------TKQGGPP-GGSS----HDK----------------- 976

  Fly   895 PEIPPYLGYSVRNLTTFAGNSRKMQQHQKLQSGASASTLALNSAAYAARMQSMHIQEIPPFRKKS 959
            |:.|                               :|.||.|:.        |.:::|.|.:.|.
 Frog   977 PKRP-------------------------------SSLLASNNV--------MKLKQIIPLQSKF 1002

  Fly   960 TDSADHTGSSASSSPQRTTMRQLSAQREPQQQTIPEIPPYKTRKISAESAMHLNMSDKLHIKLHA 1024
            .     :|::|.|                     |:.||....||
 Frog  1003 L-----SGTNAKS---------------------PQSPPATDTKI-------------------- 1021

  Fly  1025 PEWMSRLKVNDNANLHRSIDCISKELGNSADTADILKPAPSWCNVAMRSGAPGSNLATPPASQHQ 1089
            |.::|...:........|    |:|..:|....  ..|...:.......|..|.|...||.|...
 Frog  1022 PSFLSFKFLKSPETKRES----SQERAHSPTKP--FHPGKLFNFGGKGEGQVGGNGIGPPISTQP 1080

  Fly  1090 QQIVASSSSSSGGGGSVFSPSGPGPAGASGVGISNSQSRPSVGALSNSSSGSSHKQQLKQQAKEE 1154
            :...|.::||.|        :.||.:..:|:    |:.||:              ::.::|.|.:
 Frog  1081 RGATAGTASSDG--------TVPGKSQLNGI----SEDRPT--------------EEGEEQTKAQ 1119

  Fly  1155 KE 1156
            |:
 Frog  1120 KQ 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	233/667 (35%)
ano8	XP_004911073.1	Anoctamin	234..>470	CDD:282414	123/242 (51%)
		Anoctamin	<760..895	CDD:282414	76/134 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	415	1.000	Domainoid score	I663
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	568	1.000	Inparanoid score	I1056
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0001419
OrthoInspector	1	1.000	-	-		oto103826
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3826
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060